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Sleep and Breathing
Published in: Sleep and Breathing 1/2020

Open Access 01-03-2020 | Sleep Apnea | Sleep Breathing Physiology and Disorders • Original Article

Targeted sequencing analysis of PPARG identifies a risk variant associated with obstructive sleep apnea in Chinese Han subjects

Authors: Xiaolu Jiao, Song Yang, Yunyun Yang, Juan Li, Haili Sun, Ming Zhang, Yunxiao Yang, Yanwen Qin

Published in: Sleep and Breathing | Issue 1/2020

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Abstract

Purpose

Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of partial or complete upper airway obstruction. OSA susceptibility is associated with multiple genetic, environmental, and developmental factors. The PPARG rs1801282 (G/C) polymorphism has been associated with OSA in obese Indian subjects, whereas no such association has been reported in Chinese Han subjects. Potential associations between other PPARG variants and OSA have not been investigated in Chinese Han populations. The aim of this study was to identify genetic variants of PPARG in unrelated Chinese Han patients with OSA and to investigate potential associations between these variants and OSA.

Methods

We performed a cross-sectional study of 233 individuals with OSA and 93 control individuals. A portable diagnostic device was used to diagnose OSA. Targeted sequencing was conducted to identify PPARG variants. Associations between PPARG variants and OSA were analyzed using multivariate regression.

Results

Three PPARG single-nucleotide polymorphisms were identified and the genotype frequencies of the rs1801282 polymorphism differed significantly. Subjects with the PPARG rs1801282 CG genotype had decreased risk of having OSA compared with subjects with the CC genotype after adjusting for confounding effects.

Conclusions

We identified a variant of PPARG associated with the occurrence of OSA in Chinese Han populations.
Appendix
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Metadata
Title
Targeted sequencing analysis of PPARG identifies a risk variant associated with obstructive sleep apnea in Chinese Han subjects
Authors
Xiaolu Jiao
Song Yang
Yunyun Yang
Juan Li
Haili Sun
Ming Zhang
Yunxiao Yang
Yanwen Qin
Publication date
01-03-2020
Publisher
Springer International Publishing
Published in
Sleep and Breathing / Issue 1/2020
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-019-01855-x

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