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Sleep and Breathing
Published in: Sleep and Breathing 1/2020

01-03-2020 | Polysomnography | Sleep Breathing Physiology and Disorders • Original Article

Increased age adversely affects the therapeutic effect of CPAP treatment for olfactory functions

Authors: Ayse Secil Dinc, Melih Cayonu, Sezgi Sahin Duyar, Selma Fırat

Published in: Sleep and Breathing | Issue 1/2020

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Abstract

Purpose

The aim of this study was to compare olfactory functions pre- and post-CPAP treatment in patients with moderate to severe OSA, and to evaluate the factors that cause changes in olfactory functions.

Methods

Twenty-two patients who had completed regular usage of CPAP treatment for 2 months were included in this prospective study. Olfactory tests using Sniffin’ Sticks were performed pre- and post-treatment.

Results

The mean age of the subjects was 47.6 ± 9.5 years. We did not find a significant change in olfactory functions after 2 months of CPAP treatment in our study group. When the patients were divided into two groups—those whose olfactory functions showed improvement and those whose functions did not—it was found that the mean age of the patients whose olfactory functions did not improve was significantly higher statistically. A significant adverse correlation was found between age and post-treatment olfactory functions, specifically in odour threshold and odour identification scores.

Conclusions

Increased age adversely affects the therapeutic effect of CPAP treatment for olfactory functions.
Literature
1.
Senaratna CV, Perret JL, Lodge CJ, Lowe AJ, Campbell BE, Matheson MC, Hamilton GS, Dharmage SC (2017) Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev 4:70–81CrossRef
2.
Mirrakhimov AE, Sooronbaev T, Mirrakhimov EM (2013) Prevalence of obstructive sleep apnea in Asian adults: a systematic review of the literature. BMC Pulm Med 13:10CrossRef
3.
Olson EJ, Park JG, Morgenthaler TI (2005) Obstructive sleep apnea-hypopnea syndrome. Prim Care 32:329–359CrossRef
4.
Berry RB, Brooks R, Gamaldo CE (2016) For the American Academy of Sleep Medicine. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, version 2.3. American Academy of Sleep Medicine, Darien
5.
Almendros I, Acerbi I, Vilaseca I, Montserrat JM, Navajas D, Farre R (2008) Continuous positive airway pressure (CPAP) induces early nasal inflammation. Sleep 31:127–131CrossRef
6.
Magliulo G, De Vincentiis M, Iannella G, Ciofalo A, Pasquariello B, Manno A et al (2018) Olfactory evaluation in obstructive sleep apnoea patients. Acta Otorhinolaryngol Ital 38(4):338–345PubMedPubMedCentral
7.
Salihoglu M, Kendirli MT, Altundag A, Tekeli H, Saglam M, Cayonu M et al (2013) The effect of obstructive sleep apnea on olfactory functions. Laryngoscope 124:2190–2194CrossRef
8.
Farmer MN, Raddin RS, Roberts JD (2009) The relationship between taste, olfaction, and nutrition in the cancer population. J Support Oncol 7:70–72PubMed
9.
Keverne EB (2004) Importance of olfactory and vomeronasal systems for male sexual function. Physiol Behav 83:177–187CrossRef
10.
Willander J, Larsson M (2007) Olfaction and emotion: the case of autobiographical memory. Mem Cogn 35:1659–1663CrossRef
11.
Hummel T, Nordin S (2005) Olfactory disorders and their consequences for quality of life. Acta Otolaryngol 125:116–121CrossRef
12.
Sommer JU, Kraus M, Birk R, Schultz JD, Hörmann K, Stuck BA (2014) Functional short- and long-term effects of nasal CPAP with and without humidification on the ciliary function of the nasal respiratory epithelium. Sleep Breath 18:85–93CrossRef
13.
Koutsourelakis I, Vagiakis E, Perraki E, Karatza M, Magkou C, Kopaka M, Roussos C, Zakynthinos S (2011) Nasal inflammation in sleep apnoea patients using CPAP and effect of heated humidification. Eur Respir J 37:587–594CrossRef
14.
Saka C, Vuralkan E, Fırat IH, Alicura S, Hücümenoğlu S, Akın I, Ardıç S, Gökler A (2012) The effects of CPAP treatment on nasal mucosa in patients with obstructive sleep apnea. Eur Arch Otorhinolaryngol 269:2065–2067CrossRef
15.
Walliczek-Dworschak U, Cassel W, Mittendorf L, Pellegrino R, Koehler U, Güldner C, Dworschak POG, Hildebrandt O, Daniel H, Günzel T, Teymoortash A, Hummel T (2017) Continuous positive air pressure improves orthonasal olfactory function of patients with obstructive sleep apnea. Sleep Med 34:24–29CrossRef
16.
Boerner B, Tini GM, Fachinger P, Graber SM, Irani S (2017) Significant improvement of olfactory performance in sleep apnea patients after three months of nasal CPAP therapy: observational study and randomized trial. PLoS One 12:e0171087CrossRef
17.
Köseoğlu S, Derin S, Yilmaz M, Kutlu G, Sahan M (2017) Does positive airway pressure therapy improve olfactory function? Int Forum Allergy Rhinol 7:557–560CrossRef
18.
Kushida CA, Chediak A, Berry RB, Brown LK, Gozal D, Iber C, Parthasarathy S, Quan SF, Rowley JA (2008) Positive airway pressure titration task force; American Academy of Sleep Medicine. Clinical guidelines for the manual titration of positive airway pressure in patients with obstructive sleep apnea positive airway pressure. J Clin Sleep Med 4(2):157–171CrossRef
19.
Hummel T, Sekinger B, Wolf S, Pauli E, Kobal G (1997) “Sniffin’ sticks”: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 22:39–52CrossRef
20.
Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM, Seeber H, Pauli E, Hummel T (2000) Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. Eur Arch Otorhinolaryngol 257:205–211CrossRef
21.
Wolfensberger M, Schnieper I, Welge-Lussen A (2000) “Sniffin’ Sticks”: a new olfactory test battery. Acta Otolaryngol 120:303–306CrossRef
22.
Buschhüter D, Smitka M, Puschmann S, Gerber JC, Witt M, Abolmaali ND, Hummel T (2008) Correlation between olfactory bulb volume and olfactory function. Neuroimage 42:498–502CrossRef
23.
Hummel T, Kobal G, Gudziol H, Mackay-Sim A (2007) Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 264:237–243CrossRef
24.
Barnes DC, Wilson DA (2014) Sleep and olfactory cortical plasticity. Front Behav Neurosci 8:134CrossRef
25.
Daurat A, Foret J, Bret-Dibat JL, Fureix C, Tiberge M (2008) Spatial and temporal memories are affected by sleep fragmentation in obstructive sleep apnea syndrome. J Clin Exp Neuropsychol 30:91–101CrossRef
26.
Fu D, Pinto JM, Wang L, Chen G, Zhan X, Wei Y (2015) The effect of nasal structure on olfactory function in patients with OSA. Eur Arch Otorhinolaryngol 272:357–362CrossRef
27.
Verstraeten E (2007) Neurocognitive effects of obstructive sleep apnea syndrome. Curr Neurol Neurosci Rep 7:161–166CrossRef
28.
Shadan F, Jalowayski A, Fahrenholz J, Kline LE, Dawson A (2005) Nasal cytology: a marker of clinically silent inflammation in patients with obstructive sleep apnea and a predictor of noncompliance with nasal CPAP. J Clin Sleep Med 1:266–270CrossRef
29.
Iskander NM, El-Hennawi DM, Yousef TF, El-Tabbakh MT, Elnahriry TA (2017) Evaluation of the effect of cigarette smoking on the olfactory neuroepithelium of New Zealand white rabbit, using scanning electron microscope. Eur Arch Otorhinolaryngol 274(6):2461–2468CrossRef
Metadata
Title
Increased age adversely affects the therapeutic effect of CPAP treatment for olfactory functions
Authors
Ayse Secil Dinc
Melih Cayonu
Sezgi Sahin Duyar
Selma Fırat
Publication date
01-03-2020
Publisher
Springer International Publishing
Keyword
Polysomnography
Published in
Sleep and Breathing / Issue 1/2020
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-019-01889-1

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