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Published in: International Urology and Nephrology 3/2019

01-03-2019 | Nephrectomy | Urology - Review

Organ-sparing procedures in GU cancer: part 1—organ-sparing procedures in renal and adrenal tumors: a systematic review

Authors: Raouf Seyam, Mahmoud I. Khalil, Mohamed H. Kamel, Waleed M. Altaweel, Rodney Davis, Nabil K. Bissada

Published in: International Urology and Nephrology | Issue 3/2019

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Abstract

Purpose

Organ-sparing surgery (OSS) for the kidney and adrenals has emerged as the need for preservation of function is paramount in patients with poor functional reserve. As reports increasingly showed that oncological outcomes were equivalent to radical excision, elective OSS became a viable alternative in patients with otherwise normal reserve. In this review, we summarize the current knowledge of OSS for adrenal and renal tumors.

Materials and methods

PubMed, Web of Science and Cochrane Library Central Search were searched for recently published articles up to December 2017. The following keywords were used; “partial adrenalectomy”, “adrenal sparing”, “partial nephrectomy”, “nephron sparing”, “kidney/renal cancer”.

Results

Partial adrenalectomy became an attractive alternative to total adrenalectomy avoiding adrenal insufficiency. Both minimally invasive surgery and ablative techniques were increasingly reported for adrenal OSS with adequate residual adrenal function and excellent oncological outcome. Radical nephrectomy remained for many years as the gold standard of treatment for organ-confined renal cell carcinoma. As the need to reduce the impact on renal function, more conservative approaches were utilized. Soon, the non-inferiority of nephron-sparing surgery to that of radical excision became evident and elective partial nephrectomy was gaining ground as the standard of care for small renal masses in patients with normal contralateral kidneys.

Conclusions

Herein, we present a comprehensive review of the current status of OSS in renal and adrenal tumors.
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Metadata
Title
Organ-sparing procedures in GU cancer: part 1—organ-sparing procedures in renal and adrenal tumors: a systematic review
Authors
Raouf Seyam
Mahmoud I. Khalil
Mohamed H. Kamel
Waleed M. Altaweel
Rodney Davis
Nabil K. Bissada
Publication date
01-03-2019
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 3/2019
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-018-02070-5

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