Skip to main content
Top
Published in: Journal of Thrombosis and Thrombolysis 1/2016

Open Access 01-01-2016

The epidemiology of venous thromboembolism

Authors: John A. Heit, Frederick A. Spencer, Richard H. White

Published in: Journal of Thrombosis and Thrombolysis | Issue 1/2016

Login to get access

Abstract

Venous thromboembolism (VTE) is categorized by the U.S. Surgeon General as a major public health problem. VTE is relatively common and associated with reduced survival and substantial health-care costs, and recurs frequently. VTE is a complex (multifactorial) disease, involving interactions between acquired or inherited predispositions to thrombosis and VTE risk factors, including increasing patient age and obesity, hospitalization for surgery or acute illness, nursing-home confinement, active cancer, trauma or fracture, immobility or leg paresis, superficial vein thrombosis, and, in women, pregnancy and puerperium, oral contraception, and hormone therapy. Although independent VTE risk factors and predictors of VTE recurrence have been identified, and effective primary and secondary prophylaxis is available, the occurrence of VTE seems to be relatively constant, or even increasing.
Literature
1.
go back to reference Souto JC, Almasy L, Borrell M et al (2000) Genetic susceptibility to thrombosis and its relationship to physiological risk factors: the GAIT study. Genetic Analysis of Idiopathic Thrombophilia. Am J Hum Genet 67:1452–1459PubMedPubMedCentralCrossRef Souto JC, Almasy L, Borrell M et al (2000) Genetic susceptibility to thrombosis and its relationship to physiological risk factors: the GAIT study. Genetic Analysis of Idiopathic Thrombophilia. Am J Hum Genet 67:1452–1459PubMedPubMedCentralCrossRef
2.
go back to reference Ariens RA, de Lange M, Snieder H, Boothby M, Spector TD, Grant PJ (2002) Activation markers of coagulation and fibrinolysis in twins: heritability of the prethrombotic state. Lancet 359:667–671PubMedCrossRef Ariens RA, de Lange M, Snieder H, Boothby M, Spector TD, Grant PJ (2002) Activation markers of coagulation and fibrinolysis in twins: heritability of the prethrombotic state. Lancet 359:667–671PubMedCrossRef
3.
go back to reference Larsen TB, Sorensen HT, Skytthe A, Johnsen SP, Vaupel JW, Christensen K (2003) Major genetic susceptibility for venous thromboembolism in men: a study of Danish twins. Epidemiology 14:328–332PubMed Larsen TB, Sorensen HT, Skytthe A, Johnsen SP, Vaupel JW, Christensen K (2003) Major genetic susceptibility for venous thromboembolism in men: a study of Danish twins. Epidemiology 14:328–332PubMed
4.
go back to reference Heit JA, Phelps MA, Ward SA, Slusser JP, Petterson TM, De Andrade M (2004) Familial segregation of venous thromboembolism. J Thromb Haemost 2:731–736PubMedCrossRef Heit JA, Phelps MA, Ward SA, Slusser JP, Petterson TM, De Andrade M (2004) Familial segregation of venous thromboembolism. J Thromb Haemost 2:731–736PubMedCrossRef
5.
go back to reference Zoller B, Ohlsson H, Sundquist J, Sundquist K (2013) Familial risk of venous thromboembolism in first-, second- and third-degree relatives: a nationwide family study in Sweden. Thromb Haemost 109:458–463PubMedCrossRef Zoller B, Ohlsson H, Sundquist J, Sundquist K (2013) Familial risk of venous thromboembolism in first-, second- and third-degree relatives: a nationwide family study in Sweden. Thromb Haemost 109:458–463PubMedCrossRef
6.
go back to reference Zoller B, Li X, Sundquist J, Sundquist K (2012) A nationwide family study of pulmonary embolism: identification of high risk families with increased risk of hospitalized and fatal pulmonary embolism. Thromb Res 130:178–182PubMedCrossRef Zoller B, Li X, Sundquist J, Sundquist K (2012) A nationwide family study of pulmonary embolism: identification of high risk families with increased risk of hospitalized and fatal pulmonary embolism. Thromb Res 130:178–182PubMedCrossRef
7.
go back to reference Zoller B, Li X, Sundquist J, Sundquist K (2012) Shared familial aggregation of susceptibility to different manifestations of venous thromboembolism: a nationwide family study in Sweden. Br J Haematol 157:146–148PubMedCrossRef Zoller B, Li X, Sundquist J, Sundquist K (2012) Shared familial aggregation of susceptibility to different manifestations of venous thromboembolism: a nationwide family study in Sweden. Br J Haematol 157:146–148PubMedCrossRef
8.
go back to reference Anderson FA Jr, Wheeler HB, Goldberg RJ et al (1991) A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med 151:933–938PubMedCrossRef Anderson FA Jr, Wheeler HB, Goldberg RJ et al (1991) A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med 151:933–938PubMedCrossRef
9.
go back to reference Hansson PO, Welin L, Tibblin G, Eriksson H (1997) Deep vein thrombosis and pulmonary embolism in the general population. ‘The Study of Men Born in 1913′. Arch Intern Med 157:1665–1670PubMedCrossRef Hansson PO, Welin L, Tibblin G, Eriksson H (1997) Deep vein thrombosis and pulmonary embolism in the general population. ‘The Study of Men Born in 1913′. Arch Intern Med 157:1665–1670PubMedCrossRef
10.
go back to reference Silverstein MD, Heit JA, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ 3rd (1998) Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 158:585–593PubMedCrossRef Silverstein MD, Heit JA, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ 3rd (1998) Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 158:585–593PubMedCrossRef
11.
go back to reference Oger E (2000) Incidence of venous thromboembolism: a community-based study in Western France. EPI-GETBP Study Group. Groupe d’Etude de la Thrombose de Bretagne Occidentale. Thromb Haemost 83:657–660PubMed Oger E (2000) Incidence of venous thromboembolism: a community-based study in Western France. EPI-GETBP Study Group. Groupe d’Etude de la Thrombose de Bretagne Occidentale. Thromb Haemost 83:657–660PubMed
12.
go back to reference Cushman M, Tsai AW, White RH et al (2004) Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. Am J Med 117:19–25PubMedCrossRef Cushman M, Tsai AW, White RH et al (2004) Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. Am J Med 117:19–25PubMedCrossRef
13.
go back to reference Heit JA (2005) Venous thromboembolism: disease burden, outcomes and risk factors. J Thromb Haemost 3:1611–1617PubMedCrossRef Heit JA (2005) Venous thromboembolism: disease burden, outcomes and risk factors. J Thromb Haemost 3:1611–1617PubMedCrossRef
14.
go back to reference Spencer FA, Emery C, Lessard D et al (2009) The Worcester Venous Thromboembolism study: a population-based study of the clinical epidemiology of venous thromboembolism. J Gen Intern Med 21:722–727CrossRef Spencer FA, Emery C, Lessard D et al (2009) The Worcester Venous Thromboembolism study: a population-based study of the clinical epidemiology of venous thromboembolism. J Gen Intern Med 21:722–727CrossRef
15.
go back to reference Naess IA, Christiansen SC, Romundstad P, Cannegieter SC, Rosendaal FR, Hammerstrom J (2007) Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost 5:692–699PubMedCrossRef Naess IA, Christiansen SC, Romundstad P, Cannegieter SC, Rosendaal FR, Hammerstrom J (2007) Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost 5:692–699PubMedCrossRef
16.
go back to reference Spencer FA, Emery C, Joffe SW et al (2009) Incidence rates, clinical profile, and outcomes of patients with venous thromboembolism. The Worcester VTE study. J Thromb Thrombolysis 28:401–409PubMedPubMedCentralCrossRef Spencer FA, Emery C, Joffe SW et al (2009) Incidence rates, clinical profile, and outcomes of patients with venous thromboembolism. The Worcester VTE study. J Thromb Thrombolysis 28:401–409PubMedPubMedCentralCrossRef
17.
go back to reference Tagalakis V, Patenaude V, Kahn SR, Suissa S (2013) Incidence of and mortality from venous thromboembolism in a real-world population: the Q-VTE Study Cohort. Am J Med 126(832):e813–e821 Tagalakis V, Patenaude V, Kahn SR, Suissa S (2013) Incidence of and mortality from venous thromboembolism in a real-world population: the Q-VTE Study Cohort. Am J Med 126(832):e813–e821
18.
go back to reference Huang W, Goldberg RJ, Anderson FA, Kiefe CI, Spencer FA (2014) Secular trends in occurrence of acute venous thromboembolism: the Worcester VTE study (1985-2009). Am J Med 127(829–839):e825 Huang W, Goldberg RJ, Anderson FA, Kiefe CI, Spencer FA (2014) Secular trends in occurrence of acute venous thromboembolism: the Worcester VTE study (1985-2009). Am J Med 127(829–839):e825
19.
go back to reference Rothwell PM, Coull AJ, Giles MF et al (2004) Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study). Lancet 363:1925–1933PubMedCrossRef Rothwell PM, Coull AJ, Giles MF et al (2004) Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study). Lancet 363:1925–1933PubMedCrossRef
20.
go back to reference Koton S, Schneider AL, Rosamond WD et al (2014) Stroke incidence and mortality trends in US communities, 1987 to 2011. JAMA 312:259–268PubMedCrossRef Koton S, Schneider AL, Rosamond WD et al (2014) Stroke incidence and mortality trends in US communities, 1987 to 2011. JAMA 312:259–268PubMedCrossRef
21.
go back to reference White RH, Zhou H, Romano PS (1998) Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California. Ann Intern Med 128:737–740PubMedCrossRef White RH, Zhou H, Romano PS (1998) Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California. Ann Intern Med 128:737–740PubMedCrossRef
22.
go back to reference Schneider D, Lilienfeld DE, Im W (2006) The epidemiology of pulmonary embolism: racial contrasts in incidence and in-hospital case fatality. J Natl Med Assoc 98:1967–1972PubMedPubMedCentral Schneider D, Lilienfeld DE, Im W (2006) The epidemiology of pulmonary embolism: racial contrasts in incidence and in-hospital case fatality. J Natl Med Assoc 98:1967–1972PubMedPubMedCentral
23.
go back to reference Zakai NA, McClure LA, Judd SE et al (2014) Racial and regional differences in venous thromboembolism in the United States in 3 cohorts. Circulation 129:1502–1509PubMedPubMedCentralCrossRef Zakai NA, McClure LA, Judd SE et al (2014) Racial and regional differences in venous thromboembolism in the United States in 3 cohorts. Circulation 129:1502–1509PubMedPubMedCentralCrossRef
24.
go back to reference Cheuk BL, Cheung GC, Cheng SW (2004) Epidemiology of venous thromboembolism in a Chinese population. Br J Surg 91:424–428PubMedCrossRef Cheuk BL, Cheung GC, Cheng SW (2004) Epidemiology of venous thromboembolism in a Chinese population. Br J Surg 91:424–428PubMedCrossRef
25.
go back to reference Klatsky AL, Armstrong MA, Poggi J (2000) Risk of pulmonary embolism and/or deep venous thrombosis in Asian-Americans. Am J Cardiol 85:1334–1337PubMedCrossRef Klatsky AL, Armstrong MA, Poggi J (2000) Risk of pulmonary embolism and/or deep venous thrombosis in Asian-Americans. Am J Cardiol 85:1334–1337PubMedCrossRef
26.
go back to reference White RH, Zhou H, Murin S, Harvey D (2005) Effect of ethnicity and gender on the incidence of venous thromboembolism in a diverse population in California in 1996. Thromb Haemost 93:298–305PubMed White RH, Zhou H, Murin S, Harvey D (2005) Effect of ethnicity and gender on the incidence of venous thromboembolism in a diverse population in California in 1996. Thromb Haemost 93:298–305PubMed
27.
go back to reference Hooper WC, Holman RC, Heit JA, Cobb N (2002) Venous thromboembolism hospitalizations among American Indians and Alaska Natives. Thromb Res 108:273–278PubMedCrossRef Hooper WC, Holman RC, Heit JA, Cobb N (2002) Venous thromboembolism hospitalizations among American Indians and Alaska Natives. Thromb Res 108:273–278PubMedCrossRef
28.
go back to reference Heit JA, O’Fallon WM, Petterson TM et al (2002) Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Arch Intern Med 162:1245–1248PubMedCrossRef Heit JA, O’Fallon WM, Petterson TM et al (2002) Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Arch Intern Med 162:1245–1248PubMedCrossRef
29.
30.
go back to reference Heit JA, Sobell JL, Li H, Sommer SS (2005) The incidence of venous thromboembolism among Factor V Leiden carriers: a community-based cohort study. JTH 3:305–311PubMed Heit JA, Sobell JL, Li H, Sommer SS (2005) The incidence of venous thromboembolism among Factor V Leiden carriers: a community-based cohort study. JTH 3:305–311PubMed
31.
go back to reference Prandoni P, Lensing AW, Cogo A et al (1996) The long-term clinical course of acute deep venous thrombosis. Ann Intern Med 125:1–7PubMedCrossRef Prandoni P, Lensing AW, Cogo A et al (1996) The long-term clinical course of acute deep venous thrombosis. Ann Intern Med 125:1–7PubMedCrossRef
32.
go back to reference Heit JA, Mohr DN, Silverstein MD, Petterson TM, O’Fallon WM, Melton LJ 3rd (2000) Predictors of recurrence after deep vein thrombosis and pulmonary embolism: a population-based cohort study. Arch Intern Med 160:761–768PubMedCrossRef Heit JA, Mohr DN, Silverstein MD, Petterson TM, O’Fallon WM, Melton LJ 3rd (2000) Predictors of recurrence after deep vein thrombosis and pulmonary embolism: a population-based cohort study. Arch Intern Med 160:761–768PubMedCrossRef
33.
go back to reference Hansson PO, Sorbo J, Eriksson H (2000) Recurrent venous thromboembolism after deep vein thrombosis: incidence and risk factors. Arch Intern Med 160:769–774PubMedCrossRef Hansson PO, Sorbo J, Eriksson H (2000) Recurrent venous thromboembolism after deep vein thrombosis: incidence and risk factors. Arch Intern Med 160:769–774PubMedCrossRef
34.
go back to reference van Dongen CJ, Vink R, Hutten BA, Buller HR, Prins MH (2003) The incidence of recurrent venous thromboembolism after treatment with vitamin K antagonists in relation to time since first event: a meta-analysis. Arch Intern Med 163:1285–1293PubMedCrossRef van Dongen CJ, Vink R, Hutten BA, Buller HR, Prins MH (2003) The incidence of recurrent venous thromboembolism after treatment with vitamin K antagonists in relation to time since first event: a meta-analysis. Arch Intern Med 163:1285–1293PubMedCrossRef
35.
go back to reference Schulman S, Lindmarker P, Holmstrom M et al (2006) Post-thrombotic syndrome, recurrence, and death 10 years after the first episode of venous thromboembolism treated with warfarin for 6 weeks or 6 months. JTH 4:734–742PubMed Schulman S, Lindmarker P, Holmstrom M et al (2006) Post-thrombotic syndrome, recurrence, and death 10 years after the first episode of venous thromboembolism treated with warfarin for 6 weeks or 6 months. JTH 4:734–742PubMed
36.
go back to reference Prandoni P, Noventa F, Ghirarduzzi A et al (2007) The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients. Haematologica 92:199–205PubMedCrossRef Prandoni P, Noventa F, Ghirarduzzi A et al (2007) The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients. Haematologica 92:199–205PubMedCrossRef
37.
go back to reference Spencer FA, Gore JM, Lessard D, Douketis JD, Emery C, Goldberg RJ (2008) Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study. Arch Intern Med 168:425–430PubMedPubMedCentralCrossRef Spencer FA, Gore JM, Lessard D, Douketis JD, Emery C, Goldberg RJ (2008) Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study. Arch Intern Med 168:425–430PubMedPubMedCentralCrossRef
38.
go back to reference Nieto JA, Camara T, Gonzalez-Higueras E et al (2008) Clinical outcome of patients with major bleeding after venous thromboembolism. Findings from the RIETE Registry. Thromb Haemost 100:789–796PubMed Nieto JA, Camara T, Gonzalez-Higueras E et al (2008) Clinical outcome of patients with major bleeding after venous thromboembolism. Findings from the RIETE Registry. Thromb Haemost 100:789–796PubMed
39.
go back to reference White RH, Chan WS, Zhou H, Ginsberg JS (2008) Recurrent venous thromboembolism after pregnancy-associated versus unprovoked thromboembolism. Thromb Haemost 100:246–252PubMed White RH, Chan WS, Zhou H, Ginsberg JS (2008) Recurrent venous thromboembolism after pregnancy-associated versus unprovoked thromboembolism. Thromb Haemost 100:246–252PubMed
40.
go back to reference Kyrle PA, Rosendaal FR, Eichinger S (2010) Risk assessment for recurrent venous thrombosis. Lancet 376:2032–2039PubMedCrossRef Kyrle PA, Rosendaal FR, Eichinger S (2010) Risk assessment for recurrent venous thrombosis. Lancet 376:2032–2039PubMedCrossRef
41.
go back to reference Verso M, Agnelli G, Ageno W et al (2012) Long-term death and recurrence in patients with acute venous thromboembolism: the MASTER registry. Thromb Res 130:369–373PubMedCrossRef Verso M, Agnelli G, Ageno W et al (2012) Long-term death and recurrence in patients with acute venous thromboembolism: the MASTER registry. Thromb Res 130:369–373PubMedCrossRef
42.
go back to reference Schulman S, Granqvist S, Holmstrom M et al (1997) The duration of oral anticoagulant therapy after a second episode of venous thromboembolism. The Duration of Anticoagulation Trial Study Group. N Engl J Med 336:393–398PubMedCrossRef Schulman S, Granqvist S, Holmstrom M et al (1997) The duration of oral anticoagulant therapy after a second episode of venous thromboembolism. The Duration of Anticoagulation Trial Study Group. N Engl J Med 336:393–398PubMedCrossRef
43.
go back to reference Kearon C, Gent M, Hirsh J et al (1999) A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism. N Engl J Med 340:901–907PubMedCrossRef Kearon C, Gent M, Hirsh J et al (1999) A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism. N Engl J Med 340:901–907PubMedCrossRef
44.
go back to reference Agnelli G, Prandoni P, Santamaria MG et al (2001) Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis. Warfarin Optimal Duration Italian Trial Investigators. N Engl J Med 345:165–169PubMedCrossRef Agnelli G, Prandoni P, Santamaria MG et al (2001) Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis. Warfarin Optimal Duration Italian Trial Investigators. N Engl J Med 345:165–169PubMedCrossRef
45.
go back to reference Schulman S, Rhedin AS, Lindmarker P et al (1995) A comparison of six weeks with six months of oral anticoagulant therapy after a first episode of venous thromboembolism. Duration of Anticoagulation Trial Study Group. N Engl J Med 332:1661–1665PubMedCrossRef Schulman S, Rhedin AS, Lindmarker P et al (1995) A comparison of six weeks with six months of oral anticoagulant therapy after a first episode of venous thromboembolism. Duration of Anticoagulation Trial Study Group. N Engl J Med 332:1661–1665PubMedCrossRef
46.
go back to reference Agnelli G, Prandoni P, Becattini C et al (2003) Extended oral anticoagulant therapy after a first episode of pulmonary embolism. Ann Intern Med 139:19–25PubMedCrossRef Agnelli G, Prandoni P, Becattini C et al (2003) Extended oral anticoagulant therapy after a first episode of pulmonary embolism. Ann Intern Med 139:19–25PubMedCrossRef
47.
go back to reference Prandoni P, Lensing AW, Prins MH et al (2002) Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism. Ann Intern Med 137:955–960PubMedCrossRef Prandoni P, Lensing AW, Prins MH et al (2002) Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism. Ann Intern Med 137:955–960PubMedCrossRef
48.
go back to reference Kyrle PA, Eichinger S (2003) The risk of recurrent venous thromboembolism: the Austrian Study on Recurrent Venous Thromboembolism. Wien Klin Wochenschr 115:471–474PubMedCrossRef Kyrle PA, Eichinger S (2003) The risk of recurrent venous thromboembolism: the Austrian Study on Recurrent Venous Thromboembolism. Wien Klin Wochenschr 115:471–474PubMedCrossRef
49.
go back to reference Douketis JD, Foster GA, Crowther MA, Prins MH, Ginsberg JS (2000) Clinical risk factors and timing of recurrent venous thromboembolism during the initial 3 months of anticoagulant therapy. Arch Intern Med 160:3431–3436PubMedCrossRef Douketis JD, Foster GA, Crowther MA, Prins MH, Ginsberg JS (2000) Clinical risk factors and timing of recurrent venous thromboembolism during the initial 3 months of anticoagulant therapy. Arch Intern Med 160:3431–3436PubMedCrossRef
50.
go back to reference Murin S, Romano PS, White RH (2002) Comparison of outcomes after hospitalization for deep venous thrombosis or pulmonary embolism. Thromb Haemost 88:407–414PubMed Murin S, Romano PS, White RH (2002) Comparison of outcomes after hospitalization for deep venous thrombosis or pulmonary embolism. Thromb Haemost 88:407–414PubMed
51.
go back to reference Kyrle PA, Minar E, Bialonczyk C, Hirschl M, Weltermann A, Eichinger S (2004) The risk of recurrent venous thromboembolism in men and women. N Engl J Med 350:2558–2563PubMedCrossRef Kyrle PA, Minar E, Bialonczyk C, Hirschl M, Weltermann A, Eichinger S (2004) The risk of recurrent venous thromboembolism in men and women. N Engl J Med 350:2558–2563PubMedCrossRef
52.
go back to reference Laczkovics C, Grafenhofer H, Kaider A et al (2007) Risk of recurrence after a first venous thromboembolic event in young women. Haematologica 92:1201–1207PubMedCrossRef Laczkovics C, Grafenhofer H, Kaider A et al (2007) Risk of recurrence after a first venous thromboembolic event in young women. Haematologica 92:1201–1207PubMedCrossRef
53.
go back to reference Kim TM, Kim JS, Han SW et al (2009) Clinical predictors of recurrent venous thromboembolism: a single institute experience in Korea. Thromb Res 123:436–443PubMedCrossRef Kim TM, Kim JS, Han SW et al (2009) Clinical predictors of recurrent venous thromboembolism: a single institute experience in Korea. Thromb Res 123:436–443PubMedCrossRef
54.
go back to reference Eichinger S, Hron G, Bialonczyk C et al (2008) Overweight, obesity, and the risk of recurrent venous thromboembolism. Arch Intern Med 168:1678–1683PubMedCrossRef Eichinger S, Hron G, Bialonczyk C et al (2008) Overweight, obesity, and the risk of recurrent venous thromboembolism. Arch Intern Med 168:1678–1683PubMedCrossRef
55.
go back to reference Romualdi E, Squizzato A, Ageno W (2007) Abdominal obesity and the risk of recurrent deep vein thrombosis. Thromb Res 119:687–690PubMedCrossRef Romualdi E, Squizzato A, Ageno W (2007) Abdominal obesity and the risk of recurrent deep vein thrombosis. Thromb Res 119:687–690PubMedCrossRef
56.
go back to reference Garcia-Fuster MJ, Forner MJ, Fernandez C, Gil J, Vaya A, Maldonado L (2005) Long-term prospective study of recurrent venous thromboembolism in patients younger than 50 years. Pathophysiol Haemost Thromb 34:6–12PubMedCrossRef Garcia-Fuster MJ, Forner MJ, Fernandez C, Gil J, Vaya A, Maldonado L (2005) Long-term prospective study of recurrent venous thromboembolism in patients younger than 50 years. Pathophysiol Haemost Thromb 34:6–12PubMedCrossRef
57.
go back to reference Heit JA, Cunningham JM, Petterson TM, Armasu SM, Rider DN, DEA M (2011) Genetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolism. JTH 9:1133–1142PubMedPubMedCentral Heit JA, Cunningham JM, Petterson TM, Armasu SM, Rider DN, DEA M (2011) Genetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolism. JTH 9:1133–1142PubMedPubMedCentral
58.
go back to reference Agnelli G, Becattini C, Prandoni P (2004) Recurrent venous thromboembolism in men and women. N Engl J Med 351:2015–2018PubMedCrossRef Agnelli G, Becattini C, Prandoni P (2004) Recurrent venous thromboembolism in men and women. N Engl J Med 351:2015–2018PubMedCrossRef
59.
go back to reference Baglin T, Luddington R, Brown K, Baglin C (2003) Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study. Lancet 362:523–526PubMedCrossRef Baglin T, Luddington R, Brown K, Baglin C (2003) Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study. Lancet 362:523–526PubMedCrossRef
60.
go back to reference Baglin T, Luddington R, Brown K, Baglin C (2004) High risk of recurrent venous thromboembolism in men. JTH 2:2152–2155PubMed Baglin T, Luddington R, Brown K, Baglin C (2004) High risk of recurrent venous thromboembolism in men. JTH 2:2152–2155PubMed
61.
go back to reference McRae S, Tran H, Schulman S, Ginsberg J, Kearon C (2006) Effect of patient’s sex on risk of recurrent venous thromboembolism: a meta-analysis. Lancet 368:371–378PubMedCrossRef McRae S, Tran H, Schulman S, Ginsberg J, Kearon C (2006) Effect of patient’s sex on risk of recurrent venous thromboembolism: a meta-analysis. Lancet 368:371–378PubMedCrossRef
62.
go back to reference Lijfering WM, Veeger NJ, Middeldorp S et al (2009) A lower risk of recurrent venous thrombosis in women compared with men is explained by sex-specific risk factors at time of first venous thrombosis in thrombophilic families. Blood 114:2031–2036PubMedCrossRef Lijfering WM, Veeger NJ, Middeldorp S et al (2009) A lower risk of recurrent venous thrombosis in women compared with men is explained by sex-specific risk factors at time of first venous thrombosis in thrombophilic families. Blood 114:2031–2036PubMedCrossRef
63.
go back to reference Le Gal G, Kovacs MJ, Carrier M et al (2010) Risk of recurrent venous thromboembolism after a first oestrogen-associated episode. Data from the REVERSE cohort study. Thromb Haemost 104:498–503PubMedCrossRef Le Gal G, Kovacs MJ, Carrier M et al (2010) Risk of recurrent venous thromboembolism after a first oestrogen-associated episode. Data from the REVERSE cohort study. Thromb Haemost 104:498–503PubMedCrossRef
64.
go back to reference Christiansen SC, Lijfering WM, Helmerhorst FM, Rosendaal FR, Cannegieter SC (2010) Sex difference in risk of recurrent venous thrombosis and the risk profile for a second event. JTH 8:2159–2168PubMed Christiansen SC, Lijfering WM, Helmerhorst FM, Rosendaal FR, Cannegieter SC (2010) Sex difference in risk of recurrent venous thrombosis and the risk profile for a second event. JTH 8:2159–2168PubMed
65.
go back to reference Douketis J, Tosetto A, Marcucci M et al (2011) Risk of recurrence after venous thromboembolism in men and women: patient level meta-analysis. BMJ 342:d813PubMedPubMedCentralCrossRef Douketis J, Tosetto A, Marcucci M et al (2011) Risk of recurrence after venous thromboembolism in men and women: patient level meta-analysis. BMJ 342:d813PubMedPubMedCentralCrossRef
66.
go back to reference Hutten BA, Prins MH, Gent M, Ginsberg J, Tijssen JG, Buller HR (2000) Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved international normalized ratio: a retrospective analysis. J Clin Oncol 18:3078–3083PubMed Hutten BA, Prins MH, Gent M, Ginsberg J, Tijssen JG, Buller HR (2000) Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved international normalized ratio: a retrospective analysis. J Clin Oncol 18:3078–3083PubMed
67.
go back to reference Pinede L, Ninet J, Duhaut P et al (2001) Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis. Circulation 103:2453–2460PubMedCrossRef Pinede L, Ninet J, Duhaut P et al (2001) Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis. Circulation 103:2453–2460PubMedCrossRef
68.
go back to reference Prandoni P, Lensing AW, Piccioli A et al (2002) Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood 100:3484–3488PubMedCrossRef Prandoni P, Lensing AW, Piccioli A et al (2002) Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood 100:3484–3488PubMedCrossRef
69.
go back to reference Louzada ML, Majeed H, Dao V, Wells PS (2011) Risk of recurrent venous thromboembolism according to malignancy characteristics in patients with cancer-associated thrombosis: a systematic review of observational and intervention studies. Blood Coagul Fibrinolysis 22:86–91PubMedCrossRef Louzada ML, Majeed H, Dao V, Wells PS (2011) Risk of recurrent venous thromboembolism according to malignancy characteristics in patients with cancer-associated thrombosis: a systematic review of observational and intervention studies. Blood Coagul Fibrinolysis 22:86–91PubMedCrossRef
70.
go back to reference Louzada ML, Carrier M, Lazo-Langner A et al (2012) Development of a clinical prediction rule for risk stratification of recurrent venous thromboembolism in patients with cancer-associated venous thromboembolism. Circulation 126:448–454PubMedCrossRef Louzada ML, Carrier M, Lazo-Langner A et al (2012) Development of a clinical prediction rule for risk stratification of recurrent venous thromboembolism in patients with cancer-associated venous thromboembolism. Circulation 126:448–454PubMedCrossRef
71.
go back to reference Chee CE, Ashrani AA, Marks RS et al (2014) Predictors of venous thromboembolism recurrence and bleeding among active cancer patients: a population-based cohort study. Blood 123:3972–3978PubMedPubMedCentralCrossRef Chee CE, Ashrani AA, Marks RS et al (2014) Predictors of venous thromboembolism recurrence and bleeding among active cancer patients: a population-based cohort study. Blood 123:3972–3978PubMedPubMedCentralCrossRef
72.
go back to reference Iorio A, Kearon C, Filippucci E et al (2010) Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review. Arch Intern Med 170:1710–1716PubMed Iorio A, Kearon C, Filippucci E et al (2010) Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review. Arch Intern Med 170:1710–1716PubMed
73.
go back to reference Baglin T, Douketis J, Tosetto A et al (2010) Does the clinical presentation and extent of venous thrombosis predict likelihood and type of recurrence? A patient-level meta-analysis. JTH 8:2436–2442PubMed Baglin T, Douketis J, Tosetto A et al (2010) Does the clinical presentation and extent of venous thrombosis predict likelihood and type of recurrence? A patient-level meta-analysis. JTH 8:2436–2442PubMed
74.
go back to reference Kovacs MJ, Kahn SR, Wells PS et al (2010) Patients with a first symptomatic unprovoked deep vein thrombosis are at higher risk of recurrent venous thromboembolism than patients with a first unprovoked pulmonary embolism. JTH 8:1926–1932PubMed Kovacs MJ, Kahn SR, Wells PS et al (2010) Patients with a first symptomatic unprovoked deep vein thrombosis are at higher risk of recurrent venous thromboembolism than patients with a first unprovoked pulmonary embolism. JTH 8:1926–1932PubMed
75.
go back to reference Schulman S, Svenungsson E, Granqvist S (1998) Anticardiolipin antibodies predict early recurrence of thromboembolism and death among patients with venous thromboembolism following anticoagulant therapy. Duration of Anticoagulation Study Group. Am J Med 104:332–338PubMedCrossRef Schulman S, Svenungsson E, Granqvist S (1998) Anticardiolipin antibodies predict early recurrence of thromboembolism and death among patients with venous thromboembolism following anticoagulant therapy. Duration of Anticoagulation Study Group. Am J Med 104:332–338PubMedCrossRef
76.
go back to reference van den Belt AG, Sanson BJ, Simioni P et al (1997) Recurrence of venous thromboembolism in patients with familial thrombophilia. Arch Intern Med 157:2227–2232PubMedCrossRef van den Belt AG, Sanson BJ, Simioni P et al (1997) Recurrence of venous thromboembolism in patients with familial thrombophilia. Arch Intern Med 157:2227–2232PubMedCrossRef
77.
go back to reference Vossen CY, Conard J, Fontcuberta J et al (2005) Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European prospective cohort on thrombophilia (EPCOT). JTH 3:459–464PubMed Vossen CY, Conard J, Fontcuberta J et al (2005) Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European prospective cohort on thrombophilia (EPCOT). JTH 3:459–464PubMed
78.
go back to reference Brouwer JL, Lijfering WM, Ten Kate MK, Kluin-Nelemans HC, Veeger NJ, van der Meer J (2009) High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin. Thromb Haemost 101:93–99PubMed Brouwer JL, Lijfering WM, Ten Kate MK, Kluin-Nelemans HC, Veeger NJ, van der Meer J (2009) High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin. Thromb Haemost 101:93–99PubMed
79.
go back to reference den Heijer M, Willems HP, Blom HJ et al (2007) Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial. Blood 109:139–144CrossRef den Heijer M, Willems HP, Blom HJ et al (2007) Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial. Blood 109:139–144CrossRef
80.
go back to reference Verhovsek M, Douketis JD, Yi Q et al (2008) Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism. Ann Intern Med 149(481–490):W494 Verhovsek M, Douketis JD, Yi Q et al (2008) Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism. Ann Intern Med 149(481–490):W494
81.
go back to reference Douketis J, Tosetto A, Marcucci M et al (2010) Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism. Ann Intern Med 153:523–531PubMedCrossRef Douketis J, Tosetto A, Marcucci M et al (2010) Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism. Ann Intern Med 153:523–531PubMedCrossRef
82.
go back to reference Cosmi B, Legnani C, Tosetto A et al (2010) Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective study. Blood 115:481–488PubMedCrossRef Cosmi B, Legnani C, Tosetto A et al (2010) Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective study. Blood 115:481–488PubMedCrossRef
83.
go back to reference Palareti G, Cosmi B, Legnani C et al (2014) D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: a management study. Blood 124:196–203PubMedCrossRef Palareti G, Cosmi B, Legnani C et al (2014) D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: a management study. Blood 124:196–203PubMedCrossRef
84.
go back to reference Tan M, Mos IC, Klok FA, Huisman MV (2011) Residual venous thrombosis as predictive factor for recurrent venous thromboembolim in patients with proximal deep vein thrombosis: a sytematic review. Br J Haematol 153:168–178PubMedCrossRef Tan M, Mos IC, Klok FA, Huisman MV (2011) Residual venous thrombosis as predictive factor for recurrent venous thromboembolim in patients with proximal deep vein thrombosis: a sytematic review. Br J Haematol 153:168–178PubMedCrossRef
85.
go back to reference Le Gal G, Carrier M, Kovacs MJ et al (2011) Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: data from the REVERSE cohort study. JTH 9:1126–1132PubMed Le Gal G, Carrier M, Kovacs MJ et al (2011) Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: data from the REVERSE cohort study. JTH 9:1126–1132PubMed
86.
go back to reference Zhu T, Martinez I, Emmerich J (2009) Venous thromboembolism: risk factors for recurrence. Arterioscler Thromb Vasc Biol 29:298–310PubMedCrossRef Zhu T, Martinez I, Emmerich J (2009) Venous thromboembolism: risk factors for recurrence. Arterioscler Thromb Vasc Biol 29:298–310PubMedCrossRef
87.
go back to reference Cushman M, Glynn RJ, Goldhaber SZ et al (2006) Hormonal factors and risk of recurrent venous thrombosis: the prevention of recurrent venous thromboembolism trial. JTH 4:2199–2203PubMed Cushman M, Glynn RJ, Goldhaber SZ et al (2006) Hormonal factors and risk of recurrent venous thrombosis: the prevention of recurrent venous thromboembolism trial. JTH 4:2199–2203PubMed
88.
go back to reference White RH, Murin S, Wun T, Danielsen B (2010) Recurrent venous thromboembolism after surgery-provoked versus unprovoked thromboembolism. JTH 8:987–997PubMed White RH, Murin S, Wun T, Danielsen B (2010) Recurrent venous thromboembolism after surgery-provoked versus unprovoked thromboembolism. JTH 8:987–997PubMed
89.
go back to reference Douketis JD, Crowther MA, Foster GA, Ginsberg JS (2001) Does the location of thrombosis determine the risk of disease recurrence in patients with proximal deep vein thrombosis? Am J Med 110:515–519PubMedCrossRef Douketis JD, Crowther MA, Foster GA, Ginsberg JS (2001) Does the location of thrombosis determine the risk of disease recurrence in patients with proximal deep vein thrombosis? Am J Med 110:515–519PubMedCrossRef
90.
go back to reference Eichinger S, Weltermann A, Minar E et al (2004) Symptomatic pulmonary embolism and the risk of recurrent venous thromboembolism. Arch of Internal Medicine 164:92–96CrossRef Eichinger S, Weltermann A, Minar E et al (2004) Symptomatic pulmonary embolism and the risk of recurrent venous thromboembolism. Arch of Internal Medicine 164:92–96CrossRef
91.
go back to reference Jimenez D, Diaz G, Marin E, Vidal R, Sueiro A, Yusen RD (2006) The risk of recurrent venous thromboembolism in patients with unprovoked symptomatic deep vein thrombosis and asymptomatic pulmonary embolism. Thromb Haemost 95:562–566PubMed Jimenez D, Diaz G, Marin E, Vidal R, Sueiro A, Yusen RD (2006) The risk of recurrent venous thromboembolism in patients with unprovoked symptomatic deep vein thrombosis and asymptomatic pulmonary embolism. Thromb Haemost 95:562–566PubMed
92.
go back to reference Boutitie F, Pinede L, Schulman S et al (2011) Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants’ data from seven trials. BMJ 342:d3036PubMedPubMedCentralCrossRef Boutitie F, Pinede L, Schulman S et al (2011) Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants’ data from seven trials. BMJ 342:d3036PubMedPubMedCentralCrossRef
93.
go back to reference Rodger MA, Kahn SR, Wells PS et al (2008) Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy. CMAJ 179:417–426PubMedPubMedCentralCrossRef Rodger MA, Kahn SR, Wells PS et al (2008) Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy. CMAJ 179:417–426PubMedPubMedCentralCrossRef
94.
go back to reference Eichinger S, Heinze G, Jandeck LM, Kyrle PA (2010) Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model. Circulation 121:1630–1636PubMedCrossRef Eichinger S, Heinze G, Jandeck LM, Kyrle PA (2010) Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model. Circulation 121:1630–1636PubMedCrossRef
95.
go back to reference Tosetto A, Iorio A, Marcucci M et al (2012) Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: a proposed prediction score (DASH). JTH 10:1019–1025PubMed Tosetto A, Iorio A, Marcucci M et al (2012) Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: a proposed prediction score (DASH). JTH 10:1019–1025PubMed
96.
go back to reference Kyrle PA, Eichinger S (2012) Clinical scores to predict recurrence risk of venous thromboembolism. Thromb Haemost 108:1061–1064PubMedCrossRef Kyrle PA, Eichinger S (2012) Clinical scores to predict recurrence risk of venous thromboembolism. Thromb Haemost 108:1061–1064PubMedCrossRef
97.
go back to reference Poli D, Palareti G (2013) Assessing recurrence risk following acute venous thromboembolism: use of algorithms. Curr Opin Pulm Med 19:407–412PubMedCrossRef Poli D, Palareti G (2013) Assessing recurrence risk following acute venous thromboembolism: use of algorithms. Curr Opin Pulm Med 19:407–412PubMedCrossRef
98.
go back to reference den Exter PL, Kooiman J, Huisman MV (2013) Validation of the Ottawa prognostic score for the prediction of recurrent venous thromboembolism in patients with cancer-associated thrombosis. JTH 11:998–1000 den Exter PL, Kooiman J, Huisman MV (2013) Validation of the Ottawa prognostic score for the prediction of recurrent venous thromboembolism in patients with cancer-associated thrombosis. JTH 11:998–1000
99.
go back to reference Heit JA (2012) Estimating the incidence of symptomatic postoperative venous thromboembolism: the importance of perspective. JAMA 307:306–307PubMedCrossRef Heit JA (2012) Estimating the incidence of symptomatic postoperative venous thromboembolism: the importance of perspective. JAMA 307:306–307PubMedCrossRef
100.
go back to reference Yusuf H, Tsai J, Atrash HK, Boulet LP, Grosse SD (2012) Venous thromboembolism in adult hospitalizations - United States, 2007-2009. MMWR Morb Mortal Wkly Rep 61:401–404 Yusuf H, Tsai J, Atrash HK, Boulet LP, Grosse SD (2012) Venous thromboembolism in adult hospitalizations - United States, 2007-2009. MMWR Morb Mortal Wkly Rep 61:401–404
101.
go back to reference Cohoon KP, Leibson CL, Ransom JE, et al (2015) Costs of venous thromboembolism associated with hospitalization for medical illness. Am J Manag Care 21(4):e255–e263PubMedPubMedCentral Cohoon KP, Leibson CL, Ransom JE, et al (2015) Costs of venous thromboembolism associated with hospitalization for medical illness. Am J Manag Care 21(4):e255–e263PubMedPubMedCentral
102.
go back to reference Cohoon KP, Leibson CL, Ransom JE, et al (2015) Direct medical costs attributable to venous thromboembolism among persons hospitalized for major operation: a population-based longitudinal study. Surgery 157:423–431PubMedCrossRef Cohoon KP, Leibson CL, Ransom JE, et al (2015) Direct medical costs attributable to venous thromboembolism among persons hospitalized for major operation: a population-based longitudinal study. Surgery 157:423–431PubMedCrossRef
103.
go back to reference Cohoon KP, Leibson CL, Ransom JE, et al (2015) Direct medical costs attributalbe to cancer-associated venous thromboembolism: a population-based longitudinal study. J Oncol Pract Cohoon KP, Leibson CL, Ransom JE, et al (2015) Direct medical costs attributalbe to cancer-associated venous thromboembolism: a population-based longitudinal study. J Oncol Pract
104.
go back to reference Heit JA, Silverstein MD, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ 3rd (1999) Predictors of survival after deep vein thrombosis and pulmonary embolism: a population-based, cohort study. Arch Intern Med 159:445–453PubMedCrossRef Heit JA, Silverstein MD, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ 3rd (1999) Predictors of survival after deep vein thrombosis and pulmonary embolism: a population-based, cohort study. Arch Intern Med 159:445–453PubMedCrossRef
105.
go back to reference Goldhaber SZ, Visani L, De Rosa M (1999) Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet 353:1386–1389PubMedCrossRef Goldhaber SZ, Visani L, De Rosa M (1999) Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet 353:1386–1389PubMedCrossRef
106.
go back to reference Janata K, Holzer M, Domanovits H et al (2002) Mortality of patients with pulmonary embolism. Wien Klin Wochenschr 114:766–772PubMed Janata K, Holzer M, Domanovits H et al (2002) Mortality of patients with pulmonary embolism. Wien Klin Wochenschr 114:766–772PubMed
107.
go back to reference Andresen MS, Sandven I, Brunborg C et al (2011) Mortality and recurrence after treatment of VTE: long term follow-up of patients with good life-expectancy. Thromb Res 127:540–546PubMedCrossRef Andresen MS, Sandven I, Brunborg C et al (2011) Mortality and recurrence after treatment of VTE: long term follow-up of patients with good life-expectancy. Thromb Res 127:540–546PubMedCrossRef
109.
go back to reference Konstantinides S, Geibel A, Olschewski M et al (1997) Association between thrombolytic treatment and the prognosis of hemodynamically stable patients with major pulmonary embolism: results of a multicenter registry. Circulation 96:882–888PubMedCrossRef Konstantinides S, Geibel A, Olschewski M et al (1997) Association between thrombolytic treatment and the prognosis of hemodynamically stable patients with major pulmonary embolism: results of a multicenter registry. Circulation 96:882–888PubMedCrossRef
110.
go back to reference Horlander KT, Mannino DM, Leeper KV (2003) Pulmonary embolism mortality in the United States, 1979-1998: an analysis using multiple-cause mortality data. Arch Intern Med 163:1711–1717PubMedCrossRef Horlander KT, Mannino DM, Leeper KV (2003) Pulmonary embolism mortality in the United States, 1979-1998: an analysis using multiple-cause mortality data. Arch Intern Med 163:1711–1717PubMedCrossRef
111.
go back to reference Tsai J, Grosse SD, Grant AM, Hooper WC, Atrash HK (2012) Trends in in-hospital deaths among hospitalizations with pulmonary embolism. Arch Intern Med 172:960–961PubMedCrossRef Tsai J, Grosse SD, Grant AM, Hooper WC, Atrash HK (2012) Trends in in-hospital deaths among hospitalizations with pulmonary embolism. Arch Intern Med 172:960–961PubMedCrossRef
112.
go back to reference Heit JA, Silverstein MD, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ 3rd (2000) Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med 160:809–815PubMedCrossRef Heit JA, Silverstein MD, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ 3rd (2000) Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med 160:809–815PubMedCrossRef
113.
go back to reference Cushman M, Folsom AR, Wang L et al (2003) Fibrin fragment D-dimer and the risk of future venous thrombosis. Blood 101:1243–1248PubMedCrossRef Cushman M, Folsom AR, Wang L et al (2003) Fibrin fragment D-dimer and the risk of future venous thrombosis. Blood 101:1243–1248PubMedCrossRef
114.
go back to reference Smeeth L, Cook C, Thomas S, Hall AJ, Hubbard R, Vallance P (2006) Risk of deep vein thrombosis and pulmonary embolism after acute infection in a community setting. Lancet 367:1075–1079PubMedCrossRef Smeeth L, Cook C, Thomas S, Hall AJ, Hubbard R, Vallance P (2006) Risk of deep vein thrombosis and pulmonary embolism after acute infection in a community setting. Lancet 367:1075–1079PubMedCrossRef
115.
go back to reference Sweetland S, Green J, Liu B et al (2009) Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. BMJ 339:b4583PubMedPubMedCentralCrossRef Sweetland S, Green J, Liu B et al (2009) Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. BMJ 339:b4583PubMedPubMedCentralCrossRef
116.
go back to reference Bezemer ID, van der Meer FJ, Eikenboom JC, Rosendaal FR, Doggen CJ (2009) The value of family history as a risk indicator for venous thrombosis. Arch Intern Med 169:610–615PubMedCrossRef Bezemer ID, van der Meer FJ, Eikenboom JC, Rosendaal FR, Doggen CJ (2009) The value of family history as a risk indicator for venous thrombosis. Arch Intern Med 169:610–615PubMedCrossRef
117.
go back to reference Barsoum MK, Heit JA, Ashrani AA, Leibson CL, Petterson TM, Bailey KR (2010) Is progestin an independent risk factor for incident venous thromboembolism? A population-based case-control study. Thromb Res 126:373–378PubMedPubMedCentralCrossRef Barsoum MK, Heit JA, Ashrani AA, Leibson CL, Petterson TM, Bailey KR (2010) Is progestin an independent risk factor for incident venous thromboembolism? A population-based case-control study. Thromb Res 126:373–378PubMedPubMedCentralCrossRef
118.
go back to reference Roach RE, Lijfering WM, Flinterman LE, Rosendaal FR, Cannegieter SC (2013) Increased risk of CVD after VT is determined by common etiologic factors. Blood 121:4948–4954PubMedCrossRef Roach RE, Lijfering WM, Flinterman LE, Rosendaal FR, Cannegieter SC (2013) Increased risk of CVD after VT is determined by common etiologic factors. Blood 121:4948–4954PubMedCrossRef
119.
go back to reference Heit JA, Melton LJ 3rd, Lohse CM et al (2001) Incidence of venous thromboembolism in hospitalized patients vs community residents. Mayo Clin Proc 76:1102–1110PubMedCrossRef Heit JA, Melton LJ 3rd, Lohse CM et al (2001) Incidence of venous thromboembolism in hospitalized patients vs community residents. Mayo Clin Proc 76:1102–1110PubMedCrossRef
120.
go back to reference Noboa S, Mottier D, Oger E (2006) Estimation of a potentially preventable fraction of venous thromboembolism: a community-based prospective study. JTH 4:2720–2722PubMed Noboa S, Mottier D, Oger E (2006) Estimation of a potentially preventable fraction of venous thromboembolism: a community-based prospective study. JTH 4:2720–2722PubMed
121.
go back to reference Samama MM (2000) An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study. Arch Intern Med 160:3415–3420PubMedCrossRef Samama MM (2000) An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study. Arch Intern Med 160:3415–3420PubMedCrossRef
122.
go back to reference Geerts WH, Bergqvist D, Pineo GF et al (2008) Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133:381S–453SPubMedCrossRef Geerts WH, Bergqvist D, Pineo GF et al (2008) Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133:381S–453SPubMedCrossRef
123.
go back to reference Sweetland S, Parkin L, Balkwill A, Green J, Reeves G, Beral V (2013) Smoking, surgery, and venous thromboembolism risk in women: United Kingdom cohort study. Circulation 127:1276–1282PubMedCrossRef Sweetland S, Parkin L, Balkwill A, Green J, Reeves G, Beral V (2013) Smoking, surgery, and venous thromboembolism risk in women: United Kingdom cohort study. Circulation 127:1276–1282PubMedCrossRef
124.
go back to reference White RH, Zhou H, Romano PS (2003) Incidence of symptomatic venous thromboembolism after different elective or urgent surgical procedures. Thromb Haemost 90:446–455PubMed White RH, Zhou H, Romano PS (2003) Incidence of symptomatic venous thromboembolism after different elective or urgent surgical procedures. Thromb Haemost 90:446–455PubMed
125.
go back to reference Edmonds MJ, Crichton TJ, Runciman WB, Pradhan M (2004) Evidence-based risk factors for postoperative deep vein thrombosis. ANZ J Surg 74:1082–1097PubMedCrossRef Edmonds MJ, Crichton TJ, Runciman WB, Pradhan M (2004) Evidence-based risk factors for postoperative deep vein thrombosis. ANZ J Surg 74:1082–1097PubMedCrossRef
126.
go back to reference Goldhaber SZ, Tapson VF (2004) A prospective registry of 5,451 patients with ultrasound-confirmed deep vein thrombosis. Am J Cardiol 93:259–262PubMedCrossRef Goldhaber SZ, Tapson VF (2004) A prospective registry of 5,451 patients with ultrasound-confirmed deep vein thrombosis. Am J Cardiol 93:259–262PubMedCrossRef
127.
go back to reference Anderson FA Jr, Hirsh J, White K, Fitzgerald RH Jr (2003) Temporal trends in prevention of venous thromboembolism following primary total hip or knee arthroplasty 1996-2001: findings from the Hip and Knee Registry. Chest 124:349S–356SPubMedCrossRef Anderson FA Jr, Hirsh J, White K, Fitzgerald RH Jr (2003) Temporal trends in prevention of venous thromboembolism following primary total hip or knee arthroplasty 1996-2001: findings from the Hip and Knee Registry. Chest 124:349S–356SPubMedCrossRef
128.
go back to reference White RH, Gettner S, Newman JM, Trauner KB, Romano PS (2000) Predictors of rehospitalization for symptomatic venous thromboembolism after total hip arthroplasty. N Engl J Med 343:1758–1764PubMedCrossRef White RH, Gettner S, Newman JM, Trauner KB, Romano PS (2000) Predictors of rehospitalization for symptomatic venous thromboembolism after total hip arthroplasty. N Engl J Med 343:1758–1764PubMedCrossRef
129.
go back to reference Parkin L, Sweetland S, Balkwill A, Green J, Reeves G, Beral V (2012) Body mass index, surgery, and risk of venous thromboembolism in middle-aged women: a cohort study. Circulation 125:1897–1904PubMedCrossRef Parkin L, Sweetland S, Balkwill A, Green J, Reeves G, Beral V (2012) Body mass index, surgery, and risk of venous thromboembolism in middle-aged women: a cohort study. Circulation 125:1897–1904PubMedCrossRef
130.
go back to reference Mantilla CB, Horlocker TT, Schroeder DR, Berry DJ, Brown DL (2003) Risk factors for clinically relevant pulmonary embolism and deep venous thrombosis in patients undergoing primary hip or knee arthroplasty. Anesthesiology 99:552–560 discussion 555A PubMedCrossRef Mantilla CB, Horlocker TT, Schroeder DR, Berry DJ, Brown DL (2003) Risk factors for clinically relevant pulmonary embolism and deep venous thrombosis in patients undergoing primary hip or knee arthroplasty. Anesthesiology 99:552–560 discussion 555A PubMedCrossRef
131.
go back to reference Zakai NA, Wright J, Cushman M (2004) Risk factors for venous thrombosis in medical inpatients: validation of a thrombosis risk score. JTH 2:2156–2161PubMed Zakai NA, Wright J, Cushman M (2004) Risk factors for venous thrombosis in medical inpatients: validation of a thrombosis risk score. JTH 2:2156–2161PubMed
132.
go back to reference Chopard P, Spirk D, Bounameaux H (2006) Identifying acutely ill medical patients requiring thromboprophylaxis. JTH 4:915–916PubMed Chopard P, Spirk D, Bounameaux H (2006) Identifying acutely ill medical patients requiring thromboprophylaxis. JTH 4:915–916PubMed
133.
go back to reference Barbar S, Noventa F, Rossetto V et al (2010) A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the padua prediction score. JTH 8:2450–2457PubMed Barbar S, Noventa F, Rossetto V et al (2010) A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the padua prediction score. JTH 8:2450–2457PubMed
134.
go back to reference Rothberg MB, Lindenauer PK, Lahti M, Pekow PS, Selker HP (2011) Risk factor model to predict venous thromboembolism in hospitalized medical patients. J Hosp Med 6:202–209PubMedCrossRef Rothberg MB, Lindenauer PK, Lahti M, Pekow PS, Selker HP (2011) Risk factor model to predict venous thromboembolism in hospitalized medical patients. J Hosp Med 6:202–209PubMedCrossRef
135.
go back to reference Spyropoulos AC, Anderson FA Jr, Fitzgerald G et al (2011) Predictive and associative models to identify hospitalized medical patients at risk for VTE. Chest 140:706–714PubMedCrossRef Spyropoulos AC, Anderson FA Jr, Fitzgerald G et al (2011) Predictive and associative models to identify hospitalized medical patients at risk for VTE. Chest 140:706–714PubMedCrossRef
136.
go back to reference Woller SC, Stevens SM, Jones JP et al (2011) Derivation and validation of a simple model to identify venous thromboembolism risk in medical patients. Am J Med 124(947–954):e942 Woller SC, Stevens SM, Jones JP et al (2011) Derivation and validation of a simple model to identify venous thromboembolism risk in medical patients. Am J Med 124(947–954):e942
137.
go back to reference Zakai NA, Callas PW, Repp AB, Cushman M (2013) Venous thrombosis risk assessment in medical inpatients: the medical inpatients and thrombosis (MITH) study. JTH 11:634–641PubMed Zakai NA, Callas PW, Repp AB, Cushman M (2013) Venous thrombosis risk assessment in medical inpatients: the medical inpatients and thrombosis (MITH) study. JTH 11:634–641PubMed
138.
go back to reference Samama MM, Combe S, Conard J, Horellou MH (2012) Risk assessment models for thromboprophylaxis of medical patients. Thromb Res 129:127–132PubMedCrossRef Samama MM, Combe S, Conard J, Horellou MH (2012) Risk assessment models for thromboprophylaxis of medical patients. Thromb Res 129:127–132PubMedCrossRef
139.
go back to reference Rothberg MB (2014) Venous thromboembolism prophylaxis for medical patients: who needs it? JAMA Intern Med 174:1585–1586PubMedCrossRef Rothberg MB (2014) Venous thromboembolism prophylaxis for medical patients: who needs it? JAMA Intern Med 174:1585–1586PubMedCrossRef
140.
go back to reference Chew HK, Wun T, Harvey D, Zhou H, White RH (2006) Incidence of venous thromboembolism and its effect on survival among patients with common cancers. Arch Intern Med 166:458–464PubMedCrossRef Chew HK, Wun T, Harvey D, Zhou H, White RH (2006) Incidence of venous thromboembolism and its effect on survival among patients with common cancers. Arch Intern Med 166:458–464PubMedCrossRef
141.
go back to reference Blom JW, Vanderschoot JP, Oostindier MJ, Osanto S, van der Meer FJ, Rosendaal FR (2006) Incidence of venous thrombosis in a large cohort of 66,329 cancer patients: results of a record linkage study. JTH 4:529–535PubMed Blom JW, Vanderschoot JP, Oostindier MJ, Osanto S, van der Meer FJ, Rosendaal FR (2006) Incidence of venous thrombosis in a large cohort of 66,329 cancer patients: results of a record linkage study. JTH 4:529–535PubMed
142.
go back to reference Kucuk O, Kwaan HC, Gunnar W, Vazquez RM (1985) Thromboembolic complications associated with L-asparaginase therapy. Etiologic role of low antithrombin III and plasminogen levels and therapeutic correction by fresh frozen plasma. Cancer 55:702–706PubMedCrossRef Kucuk O, Kwaan HC, Gunnar W, Vazquez RM (1985) Thromboembolic complications associated with L-asparaginase therapy. Etiologic role of low antithrombin III and plasminogen levels and therapeutic correction by fresh frozen plasma. Cancer 55:702–706PubMedCrossRef
143.
go back to reference Liebman HA, Wada JK, Patch MJ, McGehee W (1982) Depression of functional and antigenic plasma antithrombin III (AT-III) due to therapy with L-asparaginase. Cancer 50:451–456PubMedCrossRef Liebman HA, Wada JK, Patch MJ, McGehee W (1982) Depression of functional and antigenic plasma antithrombin III (AT-III) due to therapy with L-asparaginase. Cancer 50:451–456PubMedCrossRef
144.
go back to reference Zangari M, Anaissie E, Barlogie B et al (2001) Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy. Blood 98:1614–1615PubMedCrossRef Zangari M, Anaissie E, Barlogie B et al (2001) Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy. Blood 98:1614–1615PubMedCrossRef
145.
go back to reference Knight R, DeLap RJ, Zeldis JB (2006) Lenalidomide and venous thrombosis in multiple myeloma. N Engl J Med 354:2079–2080PubMedCrossRef Knight R, DeLap RJ, Zeldis JB (2006) Lenalidomide and venous thrombosis in multiple myeloma. N Engl J Med 354:2079–2080PubMedCrossRef
147.
go back to reference Tafur AJ, Kalsi H, Wysokinski WE et al (2011) The association of active cancer with venous thromboembolism location: a population-based study. Mayo Clin Proc 86:25–30PubMedPubMedCentralCrossRef Tafur AJ, Kalsi H, Wysokinski WE et al (2011) The association of active cancer with venous thromboembolism location: a population-based study. Mayo Clin Proc 86:25–30PubMedPubMedCentralCrossRef
148.
go back to reference Carrier M, Le Gal G, Wells PS, Fergusson D, Ramsay T, Rodger MA (2008) Systematic review: the Trousseau syndrome revisited: should we screen extensively for cancer in patients with venous thromboembolism? Ann Intern Med 149:323–333PubMedCrossRef Carrier M, Le Gal G, Wells PS, Fergusson D, Ramsay T, Rodger MA (2008) Systematic review: the Trousseau syndrome revisited: should we screen extensively for cancer in patients with venous thromboembolism? Ann Intern Med 149:323–333PubMedCrossRef
149.
go back to reference Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW (2008) Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood 111:4902–4907PubMedPubMedCentralCrossRef Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW (2008) Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood 111:4902–4907PubMedPubMedCentralCrossRef
150.
go back to reference Ay C, Dunkler D, Marosi C et al (2010) Prediction of venous thromboembolism in cancer patients. Blood 116:5377–5382PubMedCrossRef Ay C, Dunkler D, Marosi C et al (2010) Prediction of venous thromboembolism in cancer patients. Blood 116:5377–5382PubMedCrossRef
151.
go back to reference Merrer J, De Jonghe B, Golliot F et al (2001) Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial. JAMA 286:700–707PubMedCrossRef Merrer J, De Jonghe B, Golliot F et al (2001) Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial. JAMA 286:700–707PubMedCrossRef
152.
go back to reference Decousus H, Quere I, Presles E et al (2010) Superficial venous thrombosis and venous thromboembolism: a large, prospective epidemiologic study. Ann Intern Med 152:218–224PubMedCrossRef Decousus H, Quere I, Presles E et al (2010) Superficial venous thrombosis and venous thromboembolism: a large, prospective epidemiologic study. Ann Intern Med 152:218–224PubMedCrossRef
153.
go back to reference Goldhaber SZ, Savage DD, Garrison RJ et al (1983) Risk factors for pulmonary embolism. The Framingham Study. Am J Med 74:1023–1028PubMedCrossRef Goldhaber SZ, Savage DD, Garrison RJ et al (1983) Risk factors for pulmonary embolism. The Framingham Study. Am J Med 74:1023–1028PubMedCrossRef
154.
go back to reference Cogo A, Bernardi E, Prandoni P et al (1994) Acquired risk factors for deep-vein thrombosis in symptomatic outpatients. Arch Intern Med 154:164–168PubMedCrossRef Cogo A, Bernardi E, Prandoni P et al (1994) Acquired risk factors for deep-vein thrombosis in symptomatic outpatients. Arch Intern Med 154:164–168PubMedCrossRef
155.
go back to reference Dalen JE (2003) Economy class syndrome: too much flying or too much sitting? Arch Intern Med 163:2674–2676PubMedCrossRef Dalen JE (2003) Economy class syndrome: too much flying or too much sitting? Arch Intern Med 163:2674–2676PubMedCrossRef
156.
go back to reference Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Buller HR, Rosendaal FR (2007) The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations. PLoS Med 4:e290PubMedPubMedCentralCrossRef Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Buller HR, Rosendaal FR (2007) The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations. PLoS Med 4:e290PubMedPubMedCentralCrossRef
157.
go back to reference Chandra D, Parisini E, Mozaffarian D (2009) Meta-analysis: travel and risk for venous thromboembolism. Ann Intern Med 151:180–190PubMedCrossRef Chandra D, Parisini E, Mozaffarian D (2009) Meta-analysis: travel and risk for venous thromboembolism. Ann Intern Med 151:180–190PubMedCrossRef
158.
go back to reference Watson HG, Baglin TP (2011) Guidelines on travel-related venous thrombosis. Br J Haematol 152:31–34PubMedCrossRef Watson HG, Baglin TP (2011) Guidelines on travel-related venous thrombosis. Br J Haematol 152:31–34PubMedCrossRef
159.
go back to reference Ray JG, Mamdani M, Tsuyuki RT, Anderson DR, Yeo EL, Laupacis A (2001) Use of statins and the subsequent development of deep vein thrombosis. Arch Intern Med 161:1405–1410PubMedCrossRef Ray JG, Mamdani M, Tsuyuki RT, Anderson DR, Yeo EL, Laupacis A (2001) Use of statins and the subsequent development of deep vein thrombosis. Arch Intern Med 161:1405–1410PubMedCrossRef
160.
go back to reference Lacut K, Oger E, Le Gal G et al (2004) Statins but not fibrates are associated with a reduced risk of venous thromboembolism: a hospital-based case-control study. Fundam Clin Pharmacol 18:477–482PubMedCrossRef Lacut K, Oger E, Le Gal G et al (2004) Statins but not fibrates are associated with a reduced risk of venous thromboembolism: a hospital-based case-control study. Fundam Clin Pharmacol 18:477–482PubMedCrossRef
161.
go back to reference Glynn RJ, Danielson E, Fonseca FA et al (2009) A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med 360:1851–1861PubMedPubMedCentralCrossRef Glynn RJ, Danielson E, Fonseca FA et al (2009) A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med 360:1851–1861PubMedPubMedCentralCrossRef
162.
go back to reference Doggen CJ, Smith NL, Lemaitre RN, Heckbert SR, Rosendaal FR, Psaty BM (2004) Serum lipid levels and the risk of venous thrombosis. Arterioscler Thromb Vasc Biol 24:1970–1975PubMedCrossRef Doggen CJ, Smith NL, Lemaitre RN, Heckbert SR, Rosendaal FR, Psaty BM (2004) Serum lipid levels and the risk of venous thrombosis. Arterioscler Thromb Vasc Biol 24:1970–1975PubMedCrossRef
163.
go back to reference Prandoni P, Bilora F, Marchiori A et al (2003) An association between atherosclerosis and venous thrombosis. N Engl J Med 348:1435–1441PubMedCrossRef Prandoni P, Bilora F, Marchiori A et al (2003) An association between atherosclerosis and venous thrombosis. N Engl J Med 348:1435–1441PubMedCrossRef
164.
go back to reference Marcucci R, Liotta AA, Cellai AP et al (2003) Increased plasma levels of lipoprotein(a) and the risk of idiopathic and recurrent venous thromboembolism. Am J Med 115:601–605PubMedCrossRef Marcucci R, Liotta AA, Cellai AP et al (2003) Increased plasma levels of lipoprotein(a) and the risk of idiopathic and recurrent venous thromboembolism. Am J Med 115:601–605PubMedCrossRef
165.
go back to reference Tsai AW, Cushman M, Rosamond WD, Heckbert SR, Polak JF, Folsom AR (2002) Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology. Arch Intern Med 162:1182–1189PubMedCrossRef Tsai AW, Cushman M, Rosamond WD, Heckbert SR, Polak JF, Folsom AR (2002) Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology. Arch Intern Med 162:1182–1189PubMedCrossRef
166.
go back to reference Sorensen HT, Horvath-Puho E, Pedersen L, Baron JA, Prandoni P (2007) Venous thromboembolism and subsequent hospitalisation due to acute arterial cardiovascular events: a 20-year cohort study. Lancet 370:1773–1779PubMedCrossRef Sorensen HT, Horvath-Puho E, Pedersen L, Baron JA, Prandoni P (2007) Venous thromboembolism and subsequent hospitalisation due to acute arterial cardiovascular events: a 20-year cohort study. Lancet 370:1773–1779PubMedCrossRef
167.
go back to reference Zoller B, Li X, Sundquist J, Sundquist K (2011) Venous thromboembolism does not share strong familial susceptibility with coronary heart disease: a nationwide family study in Sweden. Eur Heart J 32:2800–2805PubMedCrossRef Zoller B, Li X, Sundquist J, Sundquist K (2011) Venous thromboembolism does not share strong familial susceptibility with coronary heart disease: a nationwide family study in Sweden. Eur Heart J 32:2800–2805PubMedCrossRef
168.
go back to reference Barsoum MK, Cohoon KP, Roger VL et al (2014) Are myocardial infarction and venous thromboembolism associated? Population-based case-control and cohort studies. Thromb Res 134:593–598PubMedPubMedCentralCrossRef Barsoum MK, Cohoon KP, Roger VL et al (2014) Are myocardial infarction and venous thromboembolism associated? Population-based case-control and cohort studies. Thromb Res 134:593–598PubMedPubMedCentralCrossRef
170.
go back to reference Chamberlain AM, Folsom AR, Heckbert SR, Rosamond WD, Cushman M (2008) High-density lipoprotein cholesterol and venous thromboembolism in the Longitudinal Investigation of Thromboembolism Etiology (LITE). Blood 112:2675–2680PubMedPubMedCentralCrossRef Chamberlain AM, Folsom AR, Heckbert SR, Rosamond WD, Cushman M (2008) High-density lipoprotein cholesterol and venous thromboembolism in the Longitudinal Investigation of Thromboembolism Etiology (LITE). Blood 112:2675–2680PubMedPubMedCentralCrossRef
171.
go back to reference Chasan-Taber L, Stampfer MJ (1998) Epidemiology of oral contraceptives and cardiovascular disease. Ann Intern Med 128:467–477PubMedCrossRef Chasan-Taber L, Stampfer MJ (1998) Epidemiology of oral contraceptives and cardiovascular disease. Ann Intern Med 128:467–477PubMedCrossRef
172.
go back to reference Rosendaal FR (1999) Risk factors for venous thrombotic disease. Thromb Haemost 82:610–619PubMed Rosendaal FR (1999) Risk factors for venous thrombotic disease. Thromb Haemost 82:610–619PubMed
173.
go back to reference Gomes MP, Deitcher SR (2004) Risk of venous thromboembolic disease associated with hormonal contraceptives and hormone replacement therapy: a clinical review. Arch Intern Med 164:1965–1976PubMedCrossRef Gomes MP, Deitcher SR (2004) Risk of venous thromboembolic disease associated with hormonal contraceptives and hormone replacement therapy: a clinical review. Arch Intern Med 164:1965–1976PubMedCrossRef
174.
go back to reference Grady D, Wenger NK, Herrington D et al (2000) Postmenopausal hormone therapy increases risk for venous thromboembolic disease. The Heart and Estrogen/progestin Replacement Study. Ann Intern Med 132:689–696PubMedCrossRef Grady D, Wenger NK, Herrington D et al (2000) Postmenopausal hormone therapy increases risk for venous thromboembolic disease. The Heart and Estrogen/progestin Replacement Study. Ann Intern Med 132:689–696PubMedCrossRef
175.
go back to reference Grady D, Hulley SB, Furberg C (1997) Venous thromboembolic events associated with hormone replacement therapy. JAMA 278:477PubMedCrossRef Grady D, Hulley SB, Furberg C (1997) Venous thromboembolic events associated with hormone replacement therapy. JAMA 278:477PubMedCrossRef
176.
go back to reference Heit JA, Kobbervig CE, James AH, Petterson TM, Bailey KR, Melton LJ 3rd (2005) Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study. Ann Intern Med 143:697–706PubMedCrossRef Heit JA, Kobbervig CE, James AH, Petterson TM, Bailey KR, Melton LJ 3rd (2005) Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study. Ann Intern Med 143:697–706PubMedCrossRef
177.
go back to reference Adomaityte J, Farooq M, Qayyum R (2008) Effect of raloxifene therapy on venous thromboembolism in postmenopausal women. A meta-analysis. Thromb Haemost 99:338–342PubMed Adomaityte J, Farooq M, Qayyum R (2008) Effect of raloxifene therapy on venous thromboembolism in postmenopausal women. A meta-analysis. Thromb Haemost 99:338–342PubMed
178.
go back to reference van Hylckama Vlieg A, Helmerhorst FM, Rosendaal FR (2010) The risk of deep venous thrombosis associated with injectable depot-medroxyprogesterone acetate contraceptives or a levonorgestrel intrauterine device. Arterioscler Thromb Vasc Biol 30:2297–2300CrossRef van Hylckama Vlieg A, Helmerhorst FM, Rosendaal FR (2010) The risk of deep venous thrombosis associated with injectable depot-medroxyprogesterone acetate contraceptives or a levonorgestrel intrauterine device. Arterioscler Thromb Vasc Biol 30:2297–2300CrossRef
179.
go back to reference Smith NL, Heckbert SR, Lemaitre RN et al (2004) Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis. JAMA 292:1581–1587PubMedCrossRef Smith NL, Heckbert SR, Lemaitre RN et al (2004) Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis. JAMA 292:1581–1587PubMedCrossRef
180.
go back to reference Scarabin P-Y, Oger E, Plu-Bureau G (2003) Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk. Lancet 362(9382):428–432PubMedCrossRef Scarabin P-Y, Oger E, Plu-Bureau G (2003) Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk. Lancet 362(9382):428–432PubMedCrossRef
181.
182.
go back to reference Danilenko-Dixon DR, Heit JA, Silverstein MD et al (2001) Risk factors for deep vein thrombosis and pulmonary embolism during pregnancy or post partum: a population-based, case-control study. Am J Obstet Gynecol 184:104–110PubMedCrossRef Danilenko-Dixon DR, Heit JA, Silverstein MD et al (2001) Risk factors for deep vein thrombosis and pulmonary embolism during pregnancy or post partum: a population-based, case-control study. Am J Obstet Gynecol 184:104–110PubMedCrossRef
183.
go back to reference Roach RE, Lijfering WM, van Hylckama Vlieg A, Helmerhorst FM, Rosendaal FR, Cannegieter SC (2013) The risk of venous thrombosis in individuals with a history of superficial vein thrombosis and acquired venous thrombotic risk factors. Blood 122:4264–4269PubMedCrossRef Roach RE, Lijfering WM, van Hylckama Vlieg A, Helmerhorst FM, Rosendaal FR, Cannegieter SC (2013) The risk of venous thrombosis in individuals with a history of superficial vein thrombosis and acquired venous thrombotic risk factors. Blood 122:4264–4269PubMedCrossRef
184.
go back to reference Ludvigsson JF, Welander A, Lassila R, Ekbom A, Montgomery SM (2007) Risk of thromboembolism in 14,000 individuals with coeliac disease. Br J Haematol 139:121–127PubMedCrossRef Ludvigsson JF, Welander A, Lassila R, Ekbom A, Montgomery SM (2007) Risk of thromboembolism in 14,000 individuals with coeliac disease. Br J Haematol 139:121–127PubMedCrossRef
185.
go back to reference Shantsila E, Lip GY, Chong BH (2009) Heparin-induced thrombocytopenia. A contemporary clinical approach to diagnosis and management. Chest 135:1651–1664PubMedCrossRef Shantsila E, Lip GY, Chong BH (2009) Heparin-induced thrombocytopenia. A contemporary clinical approach to diagnosis and management. Chest 135:1651–1664PubMedCrossRef
186.
go back to reference Tsai AW, Cushman M, Tsai MY et al (2003) Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: longitudinal Investigation of Thromboembolism Etiology (LITE). Am J Hematol 72:192–200PubMedCrossRef Tsai AW, Cushman M, Tsai MY et al (2003) Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: longitudinal Investigation of Thromboembolism Etiology (LITE). Am J Hematol 72:192–200PubMedCrossRef
187.
go back to reference Den Heijer M, Lewington S, Clarke R (2005) Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. JTH 3:292–299 Den Heijer M, Lewington S, Clarke R (2005) Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. JTH 3:292–299
188.
go back to reference van Zaane B, Squizzato A, Huijgen R et al (2010) Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case-control study. Blood 115:4344–4349PubMedPubMedCentralCrossRef van Zaane B, Squizzato A, Huijgen R et al (2010) Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case-control study. Blood 115:4344–4349PubMedPubMedCentralCrossRef
189.
go back to reference Severinsen MT, Engebjerg MC, Farkas DK et al (2011) Risk of venous thromboembolism in patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study. Br J Haematol 152:360–362PubMedCrossRef Severinsen MT, Engebjerg MC, Farkas DK et al (2011) Risk of venous thromboembolism in patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study. Br J Haematol 152:360–362PubMedCrossRef
190.
go back to reference Boyle S, White RH, Brunson A, Wun T (2013) Splenectomy and the incidence of venous thromboembolism and sepsis in patients with immune thrombocytopenia. Blood 121:4782–4790PubMedPubMedCentralCrossRef Boyle S, White RH, Brunson A, Wun T (2013) Splenectomy and the incidence of venous thromboembolism and sepsis in patients with immune thrombocytopenia. Blood 121:4782–4790PubMedPubMedCentralCrossRef
191.
go back to reference Grainge MJ, West J, Card TR (2010) Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study. Lancet 375:657–663PubMedCrossRef Grainge MJ, West J, Card TR (2010) Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study. Lancet 375:657–663PubMedCrossRef
192.
go back to reference Dentali F, Squizzato A, Brivio L et al (2009) JAK2V617F mutation for the early diagnosis of Ph- myeloproliferative neoplasms in patients with venous thromboembolism: a meta-analysis. Blood 113:5617–5623PubMedCrossRef Dentali F, Squizzato A, Brivio L et al (2009) JAK2V617F mutation for the early diagnosis of Ph- myeloproliferative neoplasms in patients with venous thromboembolism: a meta-analysis. Blood 113:5617–5623PubMedCrossRef
193.
go back to reference Barbui T, Carobbio A, Cervantes F et al (2010) Thrombosis in primary myelofibrosis: incidence and risk factors. Blood 115:778–782PubMedCrossRef Barbui T, Carobbio A, Cervantes F et al (2010) Thrombosis in primary myelofibrosis: incidence and risk factors. Blood 115:778–782PubMedCrossRef
194.
go back to reference Folsom AR, Lutsey PL, Astor BC, Wattanakit K, Heckbert SR, Cushman M (2010) Chronic kidney disease and venous thromboembolism: a prospective study. Nephrol Dial Transplant 25:3296–3301PubMedPubMedCentralCrossRef Folsom AR, Lutsey PL, Astor BC, Wattanakit K, Heckbert SR, Cushman M (2010) Chronic kidney disease and venous thromboembolism: a prospective study. Nephrol Dial Transplant 25:3296–3301PubMedPubMedCentralCrossRef
195.
go back to reference Kayali F, Najjar R, Aswad F, Matta F, Stein PD (2008) Venous thromboembolism in patients hospitalized with nephrotic syndrome. Am J Med 121:226–230PubMedCrossRef Kayali F, Najjar R, Aswad F, Matta F, Stein PD (2008) Venous thromboembolism in patients hospitalized with nephrotic syndrome. Am J Med 121:226–230PubMedCrossRef
196.
go back to reference Brodsky RA (2008) Paroxysmal nocturnal hemoglobinuria: stem cells and clonality. Hematology. Am Soc Hematol Educ Program pp 111–115 Brodsky RA (2008) Paroxysmal nocturnal hemoglobinuria: stem cells and clonality. Hematology. Am Soc Hematol Educ Program pp 111–115
197.
go back to reference Bacani AK, Gabriel SE, Crowson CS, Heit JA, Matteson EL (2012) Noncardiac vascular disease in rheumatoid arthritis: increase in venous thromboembolic events? Arthritis Rheum 64:53–61PubMedPubMedCentralCrossRef Bacani AK, Gabriel SE, Crowson CS, Heit JA, Matteson EL (2012) Noncardiac vascular disease in rheumatoid arthritis: increase in venous thromboembolic events? Arthritis Rheum 64:53–61PubMedPubMedCentralCrossRef
198.
go back to reference Holmqvist ME, Neovius M, Eriksson J et al (2012) Risk of venous thromboembolism in patients with rheumatoid arthritis and association with disease duration and hospitalization. JAMA 308:1350–1356PubMedCrossRef Holmqvist ME, Neovius M, Eriksson J et al (2012) Risk of venous thromboembolism in patients with rheumatoid arthritis and association with disease duration and hospitalization. JAMA 308:1350–1356PubMedCrossRef
199.
go back to reference Arnulf I, Merino-Andreu M, Perrier A, Birolleau S, Similowski T, Derenne JP (2002) Obstructive sleep apnea and venous thromboembolism. JAMA 287:2655–2656PubMedCrossRef Arnulf I, Merino-Andreu M, Perrier A, Birolleau S, Similowski T, Derenne JP (2002) Obstructive sleep apnea and venous thromboembolism. JAMA 287:2655–2656PubMedCrossRef
200.
go back to reference Peng YH, Liao WC, Chung WS et al (2014) Association between obstructive sleep apnea and deep vein thrombosis/pulmonary embolism: a population-based retrospective cohort study. Thromb Res 134:340–345PubMedCrossRef Peng YH, Liao WC, Chung WS et al (2014) Association between obstructive sleep apnea and deep vein thrombosis/pulmonary embolism: a population-based retrospective cohort study. Thromb Res 134:340–345PubMedCrossRef
201.
go back to reference Austin H, Key NS, Benson JM et al (2007) Sickle cell trait and the risk of venous thromboembolism among blacks. Blood 110:908–912PubMedCrossRef Austin H, Key NS, Benson JM et al (2007) Sickle cell trait and the risk of venous thromboembolism among blacks. Blood 110:908–912PubMedCrossRef
202.
go back to reference Merkel PA, Lo GH, Holbrook JT et al (2005) Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener’s Clinical Occurrence of Thrombosis (WeCLOT) Study. Ann Intern Med 142:620–626PubMedCrossRef Merkel PA, Lo GH, Holbrook JT et al (2005) Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener’s Clinical Occurrence of Thrombosis (WeCLOT) Study. Ann Intern Med 142:620–626PubMedCrossRef
Metadata
Title
The epidemiology of venous thromboembolism
Authors
John A. Heit
Frederick A. Spencer
Richard H. White
Publication date
01-01-2016
Publisher
Springer US
Published in
Journal of Thrombosis and Thrombolysis / Issue 1/2016
Print ISSN: 0929-5305
Electronic ISSN: 1573-742X
DOI
https://doi.org/10.1007/s11239-015-1311-6

Other articles of this Issue 1/2016

Journal of Thrombosis and Thrombolysis 1/2016 Go to the issue