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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 1/2022

01-01-2022 | Azathioprine | Letter to Editor

Abnormal Results of Newborn Screening for SCID After Azathioprine Exposure In Utero: Benefit of TPMT Genotyping in Both Mother and Child

Authors: Maartje Blom, Ingrid Pico-Knijnenburg, Joris M. van Montfrans, Robbert G. M. Bredius, Mirjam van der Burg, Jesse J. Swen, Dagmar Berghuis

Published in: Journal of Clinical Immunology | Issue 1/2022

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Excerpt

To the Editor …
Appendix
Available only for authorised users
Literature
1.
Thomas C, et al. A severe neonatal lymphopenia associated with administration of azathioprine to the mother in a context of Crohn’s disease. J Crohn’s Colitis. 2017;12(2):258–61.CrossRef
2.
Kuo CY, et al. Profound T-cell lymphopenia associated with prenatal exposure to purine antagonists detected by TREC newborn screening. J Allergy Clin Immunol Pract. 2017;5(1):198–200.CrossRef
3.
Barbaro M, et al. Newborn screening for severe primary immunodeficiency diseases in Sweden-a 2-year pilot TREC and KREC screening study. J Clin Immunol. 2017;37(1):51–60.CrossRef
4.
Amatuni GS, et al. Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California, 2010–2017. Pediatrics. 2019;143(2):e20182300.
5.
Thomas C, et al. Clinical and economic aspects of newborn screening for severe combined immunodeficiency: DEPISTREC study results. Clin Immunol. 2019;202:33–9.CrossRef
6.
Giżewska M, et al. Newborn screening for SCID and other severe primary immunodeficiency in the Polish-German transborder area: experience from the first 14 months of collaboration. Front Immunol. 2020;11:1948–1948.CrossRef
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Gearry RB, Barclay ML. Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. J Gastroenterol Hepatol. 2005;20(8):1149–57.CrossRef
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Akbari M, et al. systematic review and meta-analysis on the effects of thiopurines on birth outcomes from female and male patients with inflammatory bowel disease. Inflamm Bowel Dis. 2012;19(1):15–22.CrossRef
9.
Colombel JF, et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn’s disease and severe myelosuppression during azathioprine therapy. Gastroenterology. 2000;118(6):1025–30.CrossRef
10.
Relling MV, et al. Clinical pharmacogenetics implementation consortium guideline for thiopurine dosing based on TPMT and NUDT15 genotypes: 2018 update. Clin Pharmacol Ther. 2019;105(5):1095–105.CrossRef
11.
Baron U, et al. Epigenetic immune cell counting in human blood samples for immunodiagnostics. Sci Transl Med. 2018; 10(452).
12.
van der Woude CJ, et al. The second European evidenced-based consensus on reproduction and pregnancy in inflammatory bowel disease. J Crohn’s Colitis. 2015;9(2):107–24.CrossRef
13.
Blom M, et al. parents’ perspectives and societal acceptance of implementation of newborn screening for SCID in the Netherlands. J Clin Immunol. 2021;41(1):99–108.CrossRef
Metadata
Title
Abnormal Results of Newborn Screening for SCID After Azathioprine Exposure In Utero: Benefit of TPMT Genotyping in Both Mother and Child
Authors
Maartje Blom
Ingrid Pico-Knijnenburg
Joris M. van Montfrans
Robbert G. M. Bredius
Mirjam van der Burg
Jesse J. Swen
Dagmar Berghuis
Publication date
01-01-2022
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 1/2022
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-021-01138-9

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