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Published in:

01-07-2016 | CME Review

Recent Advances in DOCK8 Immunodeficiency Syndrome

Authors: Qian Zhang, Huie Jing, Helen C. Su

Published in: Journal of Clinical Immunology | Issue 5/2016

Abstract

Since the discovery of the genetic basis of DOCK8 immunodeficiency syndrome (DIDS) in 2009, several hundred patients worldwide have been reported, validating and extending the initial clinical descriptions. Importantly, the beneficial role of hematopoietic stem cell transplantation for this disease has emerged, providing impetus for improved diagnosis. Additionally, several groups have further elucidated the biological functions of DOCK8 in the immune system that help explain disease pathogenesis. Here, we summarize these recent developments.

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Title: Recent Advances in DOCK8 Immunodeficiency Syndrome
Authors: Qian Zhang
Huie Jing
Helen C. Su
Publication date: 01-07-2016
Publisher: Springer US
Published in: Journal of Clinical Immunology / Issue 5/2016
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-016-0296-z

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