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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 1/2016

01-05-2016

New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression

Authors: Achilleas Floudas, Sylvie Amu, Padraic G. Fallon

Published in: Journal of Clinical Immunology | Special Issue 1/2016

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Abstract

Regulatory B (Breg) cells are important regulators of immune responses and in recent years our understanding of their phenotypical and functional characteristics has improved considerably. Initially all suppressive capabilities of Breg cells were attributed to the actions of the anti-inflammatory cytokine interleukin (IL)-10 secreted by Breg cells. Recent studies however, highlight additional and novel mechanisms that influence both the expansion of Breg cells and their capacity to suppress immunity. Here we provide an overview of the complexity of Breg cell populations and address the newly discovered IL-10 independent mechanisms of Breg cell expansion and immune-suppression.
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Metadata
Title
New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression
Authors
Achilleas Floudas
Sylvie Amu
Padraic G. Fallon
Publication date
01-05-2016
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue Special Issue 1/2016
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-016-0263-8

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