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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 6/2011

01-12-2011

Kinetics of Effector Functions and Phenotype of Virus-Specific and γδ T Lymphocytes in Primary Human Cytomegalovirus Infection During Pregnancy

Authors: Chiara Fornara, Daniele Lilleri, M. Grazia Revello, Milena Furione, Maurizio Zavattoni, Elisa Lenta, Giuseppe Gerna

Published in: Journal of Clinical Immunology | Issue 6/2011

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Abstract

The T-cell response to human cytomegalovirus (HCMV) primary infection was analyzed in 27 pregnant women during the first year after primary HCMV infection. Pregnant women with remote HCMV infection were enrolled as controls. Interferon-γ-producing T cells were readily detected at levels comparable (CD4+) or higher (CD8+) than controls, whereas the CD4+ and CD8+ lymphoproliferative response as well as IL-2 production was significantly reduced with respect to controls for at least 9 months after infection. In addition, CD45RA re-expression as well as cytotoxic T lymphocyte activity and perforin expression were the major components of the adaptive CD4+ and CD8+ T-cell immune response, while Vδ2− γδ T-cell expansion in response to HCMV infection followed kinetics similar to that of CD8+ T cells. Reduced CD45RA re-expression directly correlated with HCMV transmission to the fetus, thus providing an important prognostic parameter.
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Metadata
Title
Kinetics of Effector Functions and Phenotype of Virus-Specific and γδ T Lymphocytes in Primary Human Cytomegalovirus Infection During Pregnancy
Authors
Chiara Fornara
Daniele Lilleri
M. Grazia Revello
Milena Furione
Maurizio Zavattoni
Elisa Lenta
Giuseppe Gerna
Publication date
01-12-2011
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 6/2011
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-011-9577-8

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