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Journal of Assisted Reproduction and Genetics

Published in:

01-09-2010 | Assisted Reproduction

Human cleavage-stage embryo vitrification is comparable to slow-rate cryopreservation in cycles of assisted reproduction

Authors: Martin Graham Wilding, Clemente Capobianco, Nadia Montanaro, Genc Kabili, Loredana Di Matteo, Enrico Fusco, Brian Dale

Published in: Journal of Assisted Reproduction and Genetics | Issue 9-10/2010

Abstract

Objectives

To compare embryo survival, pregnancy and implantation rates after cryopreservation of human cleavage-stage embryos with slow-rate cryopreservation or vitrification.

Study design

262 patients, attending for assisted reproduction, were prepared for oocyte retrieval using standard controlled ovarian hyperstimulation protocols. Excess embryos were cryopreserved on day 3 either by vitrification, or slow-rate cryopreservation in a programmable freezer. Cycles of thawing were monitored for thaw efficiency, pregnancy and implantation rates.

Results

Clinical pregnancy and implantation rates were highly comparable between cycles in which day 3 embryos were thawed either after slow-rate cryopreservation or vitrification.

Conclusions

These data suggest that vitrification of human embryos during assisted reproduction cycles achieves comparable success rates to fresh cycles and therefore can be applied in the laboratory of assisted reproduction.

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Title: Human cleavage-stage embryo vitrification is comparable to slow-rate cryopreservation in cycles of assisted reproduction
Authors: Martin Graham Wilding
Clemente Capobianco
Nadia Montanaro
Genc Kabili
Loredana Di Matteo
Enrico Fusco
Brian Dale
Publication date: 01-09-2010
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 9-10/2010
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-010-9452-1

At a glance: The STEP trials

Springer Medicine

Human cleavage-stage embryo vitrification is comparable to slow-rate cryopreservation in cycles of assisted reproduction

Abstract

Objectives

Study design

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Study design

Results

Conclusions

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