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Inflammation
Published in: Inflammation 4/2019

01-08-2019 | Idiopathic Pulmonary Fibrosis | LETTER TO THE EDITOR

Pro-inflammatory S100A9 Protein: a Double-Edged Sword in Cancer?

Authors: Vahid Bagheri, Vasso Apostolopoulos

Published in: Inflammation | Issue 4/2019

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Excerpt

Calgranulins, S100A8 (calgranulin A), S100A9 (calgranulin B), and S100A12 (calgranulin C), belong to the S100 family of calcium-binding proteins that are expressed in a number of cells, particularly in human neutrophils. They act via two receptors, the receptor for advanced glycation end products (RAGE) and toll-like receptor 4 (TLR4), to stimulate pro-inflammatory responses [1, 2]. The S100A12 gene is located between S100A8 and S100A9 in the human genome, whereas it is not present in the murine genome [3]. …
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Goyette, J., and C.L. Geczy. 2011. Inflammation-associated S100 proteins: new mechanisms that regulate function. Amino Acids 41 (4): 821–842.CrossRefPubMed
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Metadata
Title
Pro-inflammatory S100A9 Protein: a Double-Edged Sword in Cancer?
Authors
Vahid Bagheri
Vasso Apostolopoulos
Publication date
01-08-2019
Publisher
Springer US
Published in
Inflammation / Issue 4/2019
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-019-00981-8

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