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Inflammation
Published in: Inflammation 5/2017

01-10-2017 | LETTER TO THE EDITOR

Comment on “Potential Effects of Calcium Binding Protein S100A12 on Severity Evaluation and Curative Effect of Severe Acute Pancreatitis”

Authors: Vahid Bagheri, Carolyn L. Geczy

Published in: Inflammation | Issue 5/2017

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Excerpt

Feng and colleagues recently investigated the role of the calcium binding protein, S100A12, in severe acute pancreatitis. They reported that this is induced by caerulein and lipopolysaccharide in mice and anti-recombinant S100A12 antibodies decreased severity [1]. They suggest that “S100A12 is a mediator, not a marker, of acute pancreatitis” and that inhibiting it may represent a novel therapeutic approach. Based on reagents used in this study (antibodies raised against human recombinant S100A12 as immunogen) and strong evidence for the absence of S100A12 in the mouse genome [2, 3], we found that conclusions drawn from this publication are misleading. …
Literature
1.
Feng, Z., Z. Yinchu, S. Yinsheng, W. Fengqing, Z. Xiaoyang, L. Jin, and G. Xiaofei. 2015. Potential effects of calcium binding protein S100A12 on severity evaluation and curative effect of severe acute pancreatitis. Inflammation 38(1): 290–297.CrossRefPubMed
2.
Fuellen, G., D. Foell, W. Nacken, C. Sorg, and C. Kerkhoff. 2003. Absence of S100A12 in mouse: implications for RAGE-S100A12 interaction. Trends in Immunology 24(12): 622–623.CrossRefPubMed
3.
Ravasi, T., K. Hsu, J. Goyette, K. Schroder, Z. Yang, F. Rahimi, L.P. Miranda, P.F. Alewood, D.A. Hume, and C. Geczy. 2004. Probing the S100 protein family through genomic and functional analysis. Genomics 84(1): 10–22.CrossRefPubMed
4.
Yan, W.X., C. Armishaw, J. Goyette, Z. Yang, H. Cai, P. Alewood, and C.L. Geczy. 2008. Mast cell and monocyte recruitment by S100A12 and its hinge domain. Journal of Biological Chemistry 283(19): 13035–13043.CrossRefPubMed
5.
Bowman, M.H., J. Wilk, A. Heydemann, G. Kim, J. Rehman, J.A. Lodato, J. Raman, and E.M. McNally. 2010. S100A12 mediates aortic wall remodeling and aortic aneurysm. Circulation Research 106(1): 145–154.CrossRef
6.
Bowman, H., A. Heydemann, J. Gawdzik, R.A. Shilling, and B. Camoretti‐Mercado. 2011. Transgenic expression of human S100A12 induces structural airway abnormalities and limited lung inflammation in a mouse model of allergic inflammation. Clinical & Experimental Allergy 41(6): 878–889.CrossRef
7.
Yan, L., L. Mathew, B. Chellan, B. Gardner, J. Earley, T.S. Puri, and M.A.H. Bowman. 2014. S100/Calgranulin-mediated inflammation accelerates left ventricular hypertrophy and aortic valve sclerosis in chronic kidney disease in a receptor for advanced glycation end products–dependent manner. Arteriosclerosis, Thrombosis, and Vascular Biology 34(7): 1399–1411.CrossRefPubMedPubMedCentral
Metadata
Title
Comment on “Potential Effects of Calcium Binding Protein S100A12 on Severity Evaluation and Curative Effect of Severe Acute Pancreatitis”
Authors
Vahid Bagheri
Carolyn L. Geczy
Publication date
01-10-2017
Publisher
Springer US
Published in
Inflammation / Issue 5/2017
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-017-0529-1

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