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Inflammation
Published in: Inflammation 3/2018

01-06-2018 | ORIGINAL ARTICLE

FGF-21 Elevated IL-10 Production to Correct LPS-Induced Inflammation

Authors: Jun-yan Li, Nan Wang, Mir Hassan Khoso, Cheng-bin Shen, Meng-ze Guo, Xin-xin Pang, De-shan Li, Wen-fei Wang

Published in: Inflammation | Issue 3/2018

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Abstract

Fibroblast growth factor 21 (FGF-21) has been previously judged as a major metabolic regulator. In this paper, we show that FGF-21 has a potential role in anti-inflammation and immunoregulation. In vivo, treatment with exogenous FGF-21 can alleviate LPS-induced inflammation. In vitro, FGF-21 inhibited LPS-induced IL-1β expression in THP-1 cells. Furthermore, besides the NF-κB pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway. This study clearly indicates that FGF21 can be used as an attractive target for the management of inflammatory disorders. This piece of research indicates that FGF-21 could have much value in the management of inflammatory disorders.
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Metadata
Title
FGF-21 Elevated IL-10 Production to Correct LPS-Induced Inflammation
Authors
Jun-yan Li
Nan Wang
Mir Hassan Khoso
Cheng-bin Shen
Meng-ze Guo
Xin-xin Pang
De-shan Li
Wen-fei Wang
Publication date
01-06-2018
Publisher
Springer US
Published in
Inflammation / Issue 3/2018
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-018-0729-3

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