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Inflammation
Published in: Inflammation 2/2017

01-04-2017 | REVIEW

MicroRNA-155: a Novel Armamentarium Against Inflammatory Diseases

Authors: Wu Xiaoyan, Eva Maria Arriero Pais, Li Lan, Chen Jingrui, Miao Lin, Patrick Asare Fordjour, Fan Guanwei

Published in: Inflammation | Issue 2/2017

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Abstract

An increasing number of diseases are being newly closely associated with inflammation, where microRNAs seem to play a critical role in the whole disease process from initiation to development. MicroRNAs are small non-coding RNAs that govern gene expression and modulation by means of mRNA degradation or translational repression. After several profound research studies, new correlations between microRNA-155 and inflammation-related diseases are strongly emerging. Hence, we review in this paper the possible molecular mechanisms of microRNA-155 in inflammatory disorders. Furthermore, we also consider the feasibility of targeting it as a bright alternative to improve the early diagnose statistics and treatments in those diseases. MicroRNA-155 features a novel breakthrough in fine-tuning inflammatory responses and, thereby, in treating a wide spectrum of diseases with inflammation as a common denominator.
Literature
1.
Bartel, D.P. 2004. MicroRNAs: genomics, biogenesis, mechanism, and function [J]. Cell 116(2): 281–297.CrossRefPubMed
2.
Tam, W., D. Ben-Yehuda, and W.S. Hayward. 1997. bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNA [J]. Molecular and Cellular Biochemistry 17(3): 1490–1502.CrossRef
3.
Tam, W. 2001. Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA [J]. Gene 274(1-2): 157–167.CrossRefPubMed
4.
O’Connell, R., D. Rao, and D. Baltimore. 2012. microRNA regulation of inflammatory responses [J]. Annual Review of Immunology 30: 295–312.CrossRefPubMed
5.
Neilsen, P.M., J.E. Noll, S. Mattiske, C.P. Bracken, P.A. Gregory, R.B. Schulz, S.P. Lim, R. Kumar, R.J. Suetani, G.J. Goodall, and D.F. Callen. 2012. Mutant p53 drives invasion in breast tumors through up-regulation of miR-155 [J]. Oncogene 32: 2992–3000.CrossRefPubMed
6.
7.
Takeda, K., and S. Akira. 2005. Toll-like receptors in innate immunity [J]. International Immunology 17(1): 1–14.CrossRefPubMed
8.
Taganov, K.D., M.P. Boldin, K.J. Chang, and D. Baltimore. 2006. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [J]. Proceedings of the National Academy of Sciences of the United States of America 103(33): 12481–12486.CrossRefPubMedPubMedCentral
9.
O’Connell, R.M., K.D. Taganov, M.P. Boldin, G. Cheng, and D. Baltimore. 2007. MicroRNA-155 is induced during the macrophage inflammatory response [J]. Proceedings of the National Academy of Sciences of the United States of America 104(5): 1604–1609.CrossRefPubMedPubMedCentral
10.
Ceppi, M., P.M. Pereira, I. Dunand-Sauthier, E. Barras, W. Reith, M.A. Santos, and P. Pierre. 2009. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells [J]. Proceedings of the National Academy of Sciences of the United States of America 106(8): 2735–2740.CrossRefPubMedPubMedCentral
11.
O’Connell, R.M., A.A. Chaudhuri, D.S. Rao, and D. Baltimore. 2009. Inositol phosphatase SHIP1 is a primary target of miR-155 [J]. Proceedings of the National Academy of Sciences of the United States of America 106(17): 7113–7118.CrossRefPubMedPubMedCentral
12.
Wang, P., J. Hou, L. Lin, C. Wang, X. Liu, D. Li, F. Ma, and Z. Wang. 2010. Cao X Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1 [J]. Journal of Immunology 185(10): 6226–6233.CrossRef
13.
Androulidaki, A., D. Iliopoulos, A. Arranz, C. Doxaki, S. Schworer, V. Zacharioudaki, A.N. Margioris, P.N. Tsichlis, and C. Tsatsanis. 2009. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs [J]. Immunity 31: 220–231.CrossRefPubMedPubMedCentral
14.
Alexander, W.S. 2002. Suppressors of cytokine signalling SOCS in the immune system[J]. Nature Reviews Immunology 2: 410–416.PubMed
15.
Kinjyo, I., T. Hanada, K. Inagaki-Ohara, H. Mori, D. Aki, M. Ohishi, H. Yoshida, M. Kubo, and A. Yoshimura. 2002. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation [J]. Immunity 17: 583–591.CrossRefPubMed
16.
Akira, S., and K. Takeda. 2004. Toll-like receptor signalling [J]. Nature Reviews Immunology 4: 499–511.CrossRefPubMed
17.
O’Neill, L.A., F.J. Sheedy, and C.E. McCoy. 2011. MicroRNAs: the fine-tuners of Toll-like receptor signaling [J]. Nature Reviews Immunology 11(3): 163–175.CrossRefPubMed
18.
Tang, B., B. Xiao, Z. Liu, N. Li, E.D. Zhu, B.S. Li, Q.H. Xie, Y. Zhuang, Q.M. Zou, and X.H. Mao. 2010. Identification of MyD88 as a novel target of miR-155, involved in negative regulation of helicobacter pylori-induced inflammation [J]. FEBS Letters 584: 1481–1486.CrossRefPubMed
19.
Hu, X., J. Ye, A. Qin, H. Zou, H. Shao, and K. Qian. 2015. Both microRNA-155 and virus-encoded MiR-155 ortholog regulate TLR3 expression [J]. PLoS One 10(5): e01260.
20.
Tili, E., J.J. Michaille, A. Cimino, S. Costinean, C.D. Dumitru, B. Adair, M. Fabbri, H. Alder, C.G. Liu, G.A. Calin, and C.M. Croce. 2007. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock [J]. The Journal of Immunology 179: 5082–5089.CrossRefPubMed
21.
Quinn, S.R., and L.A. O’Neill. 2011. A trio of microRNAs that control Toll-like receptor signaling [J]. International Immunology 23(7): 421–425.CrossRefPubMed
22.
Koch, M., H.J. Mollenkopf, U. Klemm, and T.F. Meyer. 2012. Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis [J]. Proceedings of the National Academy of Sciences of the United States of America 109(19): E1153–E1162.CrossRefPubMedPubMedCentral
23.
Schulte, L.N., A.J. Westermann, and J. Vogel. 2013. Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing [J]. Nucleic Acids Research 41(1): 542–553.CrossRefPubMed
24.
Kohanbash, G., and H. Okada. 2012. MicroRNAs and STAT interplay [J]. Seminars in Cancer Biology 22(1): 70–75.CrossRefPubMed
25.
Alexander, M., R. Hu, M.C. Runtsch, D.A. Kagele, T.L. Mosbruger, T. Tolmachova, M.C. Seabra, J.L. Round, D.M. Ward, and R.M. O’Connell. 2015. Exosome-delivered microRNAs modulate the inflammatory response to endotoxin [J]. Nature Communications 6: 7321.CrossRefPubMedPubMedCentral
26.
Nazari-Jahantigh, M., Y. Wei, H. Noels, S. Akhtar, Z. Zhou, R.R. Koenen, K. Heyll, F. Gremse, F. Kiessling, J. Grommes, C. Weber, and A. Schober. 2012. MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages [J]. Journal of Clinical Investigation 122(11): 4190–4202.CrossRefPubMedPubMedCentral
27.
Steer, C.J., and S. Subramanian. 2012. Circulating microRNAs as biomarkers: a new frontier in diagnostics [J]. Liver Transplantation 18(3): 265–269.CrossRefPubMed
28.
29.
Zheng, Y., S. Xiong, P. Jiang, R. Liu, X. Liu, J. Qian, X. Zheng, and Y. Chu. 2012. Glucocorticoids inhibit lipopolysaccharide-mediated inflammatory response by downregulating microRNA-155: a novel anti-inflammation mechanism [J]. Free Radical Biology and Medicine 52(8): 1307–1317.CrossRefPubMed
30.
Chen, Y., W. Liu, T. Sun, Y. Huang, Y. Wang, D.K. Deb, D. Yoon, J. Kong, R. Thadhani, and Y.C. Li. 2013. 1,25-Dihydroxyvitamin D promotes negative feedback regulation of toll-like receptor signaling via targeting MicroRNA-155-SOCS1 in macrophages [J]. The Journal of Immunology 190(7): 3687–3695.CrossRefPubMedPubMedCentral
31.
Boesch-Saadatmandia, C.L.A., A.E. Wagnera, A. Stachurskab, A. Jozkowiczb, J. Dulakb, F. Döringa, S. Wolfframc, and G. Rimbacha. 2011. Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155 [J]. Journal of Nutritional Biochemistry 22: 293–299.CrossRef
32.
Tili, E.M.J.-J., B. Adair, H. Alder, E. Limagne, C. Taccioli, M. Ferracin, D. Delmas, N. Latruffe, and C.M. Croce. 2010. Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD [J]. Carcinogenesis 31: 1561–1566.CrossRefPubMedPubMedCentral
33.
Wagner, AEB-SC, J. Dose, G. Schultheiss, G. Rimbach. 2011. Anti-inflammatory potential of allylisothiocyanate-role of Nrf2, NF-κB and microRNA-155 [J]. Journal of Cellular and Molecular Medicine 1582-4934.
34.
Kleemann, R., L. Verschuren, M. Morrison, S. Zadelaar, M.J. van Erk, P.Y. Wielinga, and T. Kooistra. 2011. Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models [J]. Atherosclerosis 218(1): 44–52.CrossRefPubMed
35.
Banerjee, N., S. Talcott, S. Safe, and S.U. Mertens-Talcott. 2012. Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo - potential role of miRNA-27a and miRNA-155 in cell survival and inflammation [J]. Breast Cancer Research and Treatment 136(1): 21–34.CrossRefPubMedPubMedCentral
36.
Marcucci, G., K.S. Maharry, K.H. Metzeler, S. Volinia, Y.Z. Wu, K. Mrózek, D. Nicolet, J. Kohlschmidt, S.P. Whitman, J.H. Mendler, S. Schwind, H. Becker, A.K. Eisfeld, A.J. Carroll, B.L. Powell, J.E. Kolitz, R. Garzon, M.A. Caligiuri, R.M. Stone, and C.D. Bloomfield. 2013. Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients[J]. Journal of Clinical Oncology 31(17): 2086–2093.CrossRefPubMedPubMedCentral
37.
Gosain, A., and L.A. DiPietro. 2004. Aging and wound healing [J]. World Journal of Surgery 28: 321–326.CrossRefPubMed
38.
van Solingen, C., E. Araldi, A. Chamorro-Jorganes, C. Fernández-Hernando, and Y. Suárez. 2014. Improved repair of dermal wounds in mice lacking microRNA-155 [J]. Journal of Cellular and Molecular Medicine 18(6): 1104–1112.CrossRefPubMedPubMedCentral
39.
Diegelmann, R.F., and M.C. Evans. 2004. Wound healing: an overview of acute, fibrotic and delayed healing [J]. Frontiers in Bioscience 9: 283–289.CrossRefPubMed
40.
Reed, M.J., L. Cooper, W. Wood, B. Stramer, and P. Martin. 2004. Wound healing and inflammation: embryos reveal the way to perfect repair [J]. Philosophical Transactions of the Royal Society of London 359: 777–784.CrossRef
41.
Mescher, A.L., and A.W. Neff. 2005. Regenerative capacity and the developing immune system [J]. Advances in Biochemical Engineering and Biotechnology 93: 39–66.
42.
Yang, L.L., J.Q. Liu, X.Z. Bai, L. Fan, F. Han, W.B. Jia, L.L. Su, J.H. Shi, C.W. Tang, and D.H. Hu. 2014. Acute downregulation of miR-155 at wound sites leads to a reduced fibrosis through attenuating inflammatory response [J]. Biochemical and Biophysical Research Communications 453(1): 153–159.CrossRefPubMed
43.
Salisbury, J.R. 1993. The pathology of the human notochord [J]. The Journal of Pathology 171: 253–255.CrossRefPubMed
44.
Fuchs, B., I.D. Dickey, M.J. Yaszemski, C.Y. Inwards, and F.H. Sim. 2005. Operative management of sacral chordoma [J]. Journal of Bone and Joint Surgery (American) 87: 2211–2216.
45.
Osaka, E., A.D. Kelly, D. Spentzos, E. Choy, X. Yang, J.K. Shen, P. Yang, H.J. Mankin, F.J. Hornicek, and Z. Duan. 2015. MicroRNA-155 expression is independently predictive of outcome in chordoma [J]. Oncotarget 6(11): 9125–9139.CrossRefPubMedPubMedCentral
46.
Mitchell, P.S., R.K. Parkin, E.M. Kroh, B.R. Fritz, S.K. Wyman, E.L. Pogosova Agadjanyan, A. Peterson, J. Noteboom, K.C. O’Briant, A. Allen, D.W. Lin, N. Urban, C.W. Drescher, B.S. Knudsen, D.L. Stirewalt, R. Gentleman, R.L. Vessella, P.S. Nelson, D.B. Martin, and M. Tewari. 2008. Circulating microRNAs as stable blood-based markers for cancer detection [J]. Proceedings of the National Academy of Sciences of the United States of America 105: 10513–10518.CrossRefPubMedPubMedCentral
47.
Creemers, E.E., A.J. Tijsen, and Y.M. Pinto. 2012. Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? [J]. Circulation Research 110(3): 483–495.CrossRefPubMed
48.
Olson, E.N. 2014. MicroRNAs as therapeutic targets and biomarkers of cardiovascular disease [J]. Science Translational Medicine 6(239): 239.CrossRef
49.
50.
Romaine, S.P., M. Tomaszewski, G. Condorelli, and N.J. Samani. 2015. MicroRNAs in cardiovascular disease: an introduction for clinicians [J]. Heart 101(12): 921–928.CrossRefPubMedPubMedCentral
Metadata
Title
MicroRNA-155: a Novel Armamentarium Against Inflammatory Diseases
Authors
Wu Xiaoyan
Eva Maria Arriero Pais
Li Lan
Chen Jingrui
Miao Lin
Patrick Asare Fordjour
Fan Guanwei
Publication date
01-04-2017
Publisher
Springer US
Published in
Inflammation / Issue 2/2017
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-016-0488-y

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