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01-04-2016 | ORIGINAL ARTICLE

Protective Effects of Growth Arrest-Specific Protein 6 (Gas6) on Sepsis-Induced Acute Kidney Injury

Authors: Long-wang Chen, Wei Chen, Zhi-qiang Hu, Jia-lan Bian, Lan Ying, Guang-liang Hong, Qiao-meng Qiu, Guang-ju Zhao, Zhong-qiu Lu

Published in: Inflammation | Issue 2/2016

Abstract

Acute kidney injury (AKI) is a serious complication of sepsis, which has a high mortality rate. Growth arrest-specific protein 6 (Gas6), the protein product of the growth arrest specific gene 6, has been shown to have an anti-apoptotic effect as well as pro-survival capability. Here, we investigated the effects of Gas6 on sepsis-associated AKI in mice subjected to cecal ligation and puncture (CLP). We found that the administration of rmGas6 significantly reduced serum urea nitrogen and creatinine and improved the survival of septic mice. Furthermore, the renal pathological damage induced by CLP was attenuated by rmGas6 treatment. Finally, rmGas6 reduced the renal tissue apoptotic index and the expression of Bax, while it upregulated the expression of Bcl-2. The data suggest that rmGas6 might be used as a potential therapeutic agent for sepsis-induced AKI.

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Title: Protective Effects of Growth Arrest-Specific Protein 6 (Gas6) on Sepsis-Induced Acute Kidney Injury
Authors: Long-wang Chen
Wei Chen
Zhi-qiang Hu
Jia-lan Bian
Lan Ying
Guang-liang Hong
Qiao-meng Qiu
Guang-ju Zhao
Zhong-qiu Lu
Publication date: 01-04-2016
Publisher: Springer US
Published in: Inflammation / Issue 2/2016
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-015-0282-2

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