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Inflammation
Published in: Inflammation 2/2016

01-04-2016 | ORIGINAL ARTICLE

Artesunate Protects Against Sepsis-Induced Lung Injury Via Heme Oxygenase-1 Modulation

Authors: Tian-hui Cao, Song-gen Jin, Dong-sheng Fei, Kai Kang, Lei Jiang, Zhi-yuan Lian, Shang-ha Pan, Ming-ran Zhao, Ming-yan Zhao

Published in: Inflammation | Issue 2/2016

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Abstract

Artesunate, a derivative of artemisinin, has anti-inflammatory properties and exerts protective roles in sepsis. Heme oxygense-1 (HO-1) inhibits the inflammatory response through reduction of proinflammatory cytokines and leukocyte influx into tissues. The present study investigated the effects of artesunate on HO-1 and septic lung injury. Cecal ligation and puncture (CLP) was employed to induce septic lung injury. Mice pretreated with artesunate (AS) (15 mg/kg) exhibited decreased sepsis-induced mortality and lung injury and alleviated lung pathological changes and neutrophil infiltration. In addition, AS lowered the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the serum and bronchoalveolar lavage fluid (BALF) and inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase isoform (iNOS) expression and NF-κB activation in lung tissue. In addition, AS enhanced NF-E2-related factor-2 (Nrf2) activation and HO-1 expression and enzymatic activity in lung tissue. However, the protective effects of AS on sepsis-induced lung injury were eliminated by ZnPP IX, an HO-1 competitive inhibitor. Therefore, AS plays protective roles in septic lung injury related to the upregulation of HO-1. These findings suggest an effective and applicable treatment to sepsis-induced lung injury and provide new insights into the molecular mechanisms and actions of AS.
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Metadata
Title
Artesunate Protects Against Sepsis-Induced Lung Injury Via Heme Oxygenase-1 Modulation
Authors
Tian-hui Cao
Song-gen Jin
Dong-sheng Fei
Kai Kang
Lei Jiang
Zhi-yuan Lian
Shang-ha Pan
Ming-ran Zhao
Ming-yan Zhao
Publication date
01-04-2016
Publisher
Springer US
Published in
Inflammation / Issue 2/2016
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-015-0290-2

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