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Published in:

01-09-2021 | Myocardial Infarction

Environmentally responsive hydrogels for repair of cardiovascular tissue

Authors: Shuaimeng Guan, Jiankang Li, Kun Zhang, Jingan Li

Published in: Heart Failure Reviews | Issue 5/2021

Abstract

Cardiovascular diseases (CVDs) pose a serious threat to human health, which are characterized by high disability and mortality rate globally such as myocardial infarction (MI), atherosclerosis, and heart failure. Although stem cells transplantation and growth factors therapy are promising, their low survival rate and loss at the site of injury are major obstacles to this therapy. Recently, the development of hydrogel scaffold materials provides a new way to solve this problem, which have shown the potential to treat CVD. Among these scaffold materials, environmentally responsive hydrogels have great prospects in repairing the microenvironment of cardiovascular tissues and vascular regeneration. They provide a new method for the treatment of cardiovascular tissue repair and space-time control for the release of various therapeutic drugs, including small-molecule drugs, growth factors, and stem cells. Herein, this article reviews the occurrence and current treatment of CVD, as well as the repair of cardiovascular injury by several environmental responsive hydrogels systems currently used, mainly focusing on the delivery of growth factors or the application of cell therapy to revascularization. In addition, we will also discuss the enormous potential and personal perspectives of environmentally responsive hydrogels in cardiovascular repair.

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Title: Environmentally responsive hydrogels for repair of cardiovascular tissue
Authors: Shuaimeng Guan
Jiankang Li
Kun Zhang
Jingan Li
Publication date: 01-09-2021
Publisher: Springer US
Keywords: Myocardial Infarction
Growth Factors
Growth Factors
Published in: Heart Failure Reviews / Issue 5/2021
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-020-09934-y

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