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01-01-2020 | Gout

Hyperuricemia: a novel old disorder—relationship and potential mechanisms in heart failure

Authors: Claudio Borghi, Alberto Palazzuoli, Matteo Landolfo, Eugenio Cosentino

Published in: Heart Failure Reviews | Issue 1/2020

Abstract

Uric acid, the metabolic mediator of gout and urate renal stones, is associated with increased cardiovascular risk burden. Hyperuricemia is an old emerging metabolic disorder, and interaction among uric acid and cardiovascular diseases has been clearly described. Several illness including hypertension, myocardial infarction, metabolic syndrome, and heart failure, are related with uric acid levels increase. In this review, we will discuss the pathophysiology of hyperuricemia and describe the biological plausibility for this metabolite to participate in the pathogenesis of cardiovascular disorders. In particular, we will focus on the implications of hyperuricemia in the onset and progression of heart failure, paying special attention to the pathophysiology and the possible clinical implications. We will conclude by discussing the effects of lowering plasma uric acid concentration on the prognosis of heart failure by reviewing most of available data on the different classes of drugs directly or indirectly involved in the hyperuricemia management.

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Title: Hyperuricemia: a novel old disorder—relationship and potential mechanisms in heart failure
Authors: Claudio Borghi
Alberto Palazzuoli
Matteo Landolfo
Eugenio Cosentino
Publication date: 01-01-2020
Publisher: Springer US
Keywords: Gout
Xanthine Alkaloid
Heart Failure
Allopurinol
Febuxostat
Published in: Heart Failure Reviews / Issue 1/2020
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-019-09869-z

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