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Published in:

01-06-2008

Mitochondrial centrality in heart failure

Authors: José Marín-García, Michael J. Goldenthal

Published in: Heart Failure Reviews | Issue 2/2008

Abstract

A number of observations have shown that mitochondria are at the center of the pathophysiology of the failing heart and mitochondrial-based oxidative stress (OS), myocardial apoptosis, and cardiac bioenergetic dysfunction are implicated in the progression of heart failure (HF), as shown by both clinical studies and animal models. In this manuscript, we review the body of evidence that multiple defects in mitochondria are central and primary to HF progression. In addition, novel approaches to therapeutic targeting of mitochondrial bioenergetic, biogenic, and signaling abnormalities that can impact HF are discussed.

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Title: Mitochondrial centrality in heart failure
Authors: José Marín-García
Michael J. Goldenthal
Publication date: 01-06-2008
Publisher: Springer US
Published in: Heart Failure Reviews / Issue 2/2008
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-007-9079-1

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