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Heart Failure Reviews
Published in: Heart Failure Reviews 2/2008

01-06-2008

Programmed cell death in cardiac myocytes: strategies to maximize post-ischemic salvage

Author: Kartik Mani

Published in: Heart Failure Reviews | Issue 2/2008

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Abstract

The most common cause of systolic dysfunction in the United States is prior ischemic injury. As the basic functional unit of the myocardium, the cardiac myocyte is the ultimate target of both the pathogenesis and possible therapies in this paradigm. Maintaining adequate numbers of these terminally differentiated units in the myocardium has been the focus of all therapies in ischemic syndromes, including reperfusion strategies. Programmed cell death, in the forms of apoptosis, necrosis and possibly, autophagic cell death are the final arbiters of myocyte numbers following myocardial infarction. This review will focus on the evidence for cell death in the development of heart failure following myocardial infarction, a brief review of the relevant pathways and the targets for development of future therapies
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Metadata
Title
Programmed cell death in cardiac myocytes: strategies to maximize post-ischemic salvage
Author
Kartik Mani
Publication date
01-06-2008
Publisher
Springer US
Published in
Heart Failure Reviews / Issue 2/2008
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-007-9073-7

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