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Published in:

01-06-2008

Intracellular devastation in heart failure

Authors: Federica del Monte, Roger J. Hajjar

Published in: Heart Failure Reviews | Issue 2/2008

Abstract

End-stage heart failure is characterized by a number of abnormalities at the cellular level, which include changes in excitation–contraction coupling, alterations in contractile proteins and activation/deactivation of signaling pathways. Even though many of these changes are adaptive to the high workload and stress in heart failure, a significant number of these alterations are deeply deleterious to the cardiac cell. In this article, we will review the changes in calcium cycling that occur in myopathic hearts and how they can be effectively targeted. We will also focus on protein misfolding in the setting of cardiac dysfunction.

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Title: Intracellular devastation in heart failure
Authors: Federica del Monte
Roger J. Hajjar
Publication date: 01-06-2008
Publisher: Springer US
Published in: Heart Failure Reviews / Issue 2/2008
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-007-9071-9

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