Top

Published in:

01-11-2010 | Review

IgG₄-Related Sclerosing Disease: A Novel Mimic of Inflammatory Bowel Disease

Authors: Neeraj Narula, Monica Vasudev, John K. Marshall

Published in: Digestive Diseases and Sciences | Issue 11/2010

Abstract

High levels of IgG4-positive plasma cells are commonly seen in autoimmune pancreatitis. It has recently become evident that autoimmune pancreatitis is one component of a larger multi-system disease. IgG4-positive plasma cells have been identified in many extrapancreatic tissues, including the colon, biliary tract, liver, and lungs, and thus the term “IgG4-related sclerosing disease” has been proposed. Awareness of IgG4-related sclerosing disease is important, as it has been shown to mimic other conditions like malignancy. This review discusses IgG4-related colitis and its potential for mimicking inflammatory bowel disease.

Yoshida K, Toki F, Takeuchi T, et al. Chronic pancreatitis caused by autoimmune abnormality. Proposal of concept of autoimmune pancreatitis. Dig Dis Sci. 1995;40:1561–1568.CrossRefPubMed

Kim MH, Kwon S. Diagnostic criteria for autoimmune chronic pancreatitis. J Gastroenterol. 2007;42:42–49.CrossRefPubMed

Nishimori I, Tamakoshi A, Otsuki M. Research committee on intractable diseases of the pancreas, Ministry of Health, Labour, and Welfare of Japan. Prevalence of autoimmune pancreatitis in Japan from a nationwide survey in 2002. J Gastroenterol. 2007;42:6–8.CrossRefPubMed

Pearson RK, Longnecker DS, Chari ST, et al. Controversies in clinical pancreatology: autoimmune pancreatitis: does it exist? Pancreas. 2003;27:1–13.CrossRefPubMed

Sah RP, Pannala R, Chari ST, et al. Prevalence, diagnosis, and profile of autoimmune pancreatitis presenting with features of acute or chronic pancreatitis. Clin Gastroenterol Hepatol. 2010;8:91–96.CrossRefPubMed

Zamboni G, Lüttges J, Capelli P, et al. Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens. Virchows Arch. 2004;445:552–563.CrossRefPubMed

Weber SM, Cubukcu-Dimopulo O, Palesty JA, et al. Lymphoplasmacytic sclerosing pancreatitis: inflammatory mimic of pancreatic carcinoma. J Gastrointest Surg. 2003;7:129–137.CrossRefPubMed

Notohara K, Burgart LJ, Yadav D, et al. Idiopathic chronic pancreatitis with periductal lymphoplasmacytic infiltration: clinicopathologic features of 35 cases. Am J Surg Pathol. 2003;27:1119–1127.CrossRefPubMed

Klöppel G, Lüttges J, Löhr M, et al. Autoimmune pancreatitis: pathological, clinical, and immunological features. Pancreas. 2003;27:14–19.CrossRefPubMed

10.

Kim KP, Kim MH, Song MH, et al. Autoimmune chronic pancreatitis. Am J Gastroenterol. 2004;99:1605–1616.CrossRefPubMed

11.

Morselli-Labate AM, Pezzilli R. Usefulness of serum IgG4 in the diagnosis and follow up of autoimmune pancreatitis: a systematic literature review and meta-analysis. J Gastroenterol Hepatol. 2009;24:15–36.CrossRefPubMed

12.

Ghazale A, Chari ST, Smyrk TC, et al. Value of serum IgG4 in the diagnosis of autoimmune pancreatitis and in distinguishing it from pancreatic cancer. Am J Gastroenterol. 2007;102:1646–1653.CrossRefPubMed

13.

Frulloni L, Lunardi C, Simone R, et al. Identification of a novel antibody associated with autoimmune pancreatitis. NEJM. 2009;361:2135–2142.CrossRefPubMed

14.

Kamisawa T, Naoto E, Hitoshi N, et al. Comparison of radiological and histological features in autoimmune pancreatitis. Hepatogastroenterology. 2006;53:953–956.PubMed

15.

Chang WI, Kim BJ, Lee JK, et al. The clinical and radiological characteristics of focal mass-forming autoimmune pancreatitis: comparison with chronic pancreatitis and pancreatic cancer. Pancreas. 2009;38:401–408.CrossRefPubMed

16.

Nakazawa T, Ohara H, Yamada T, et al. Atypical primary sclerosing cholangitis cases associated with unusual pancreatitis. Hepatogastroenterology. 2001;48:625–630.PubMed

17.

Kamisawa T, Funata N, Hayashi Y, et al. Close relationship between autoimmune pancreatitis and multifocal fibrosclerosis. Gut. 2003;52:683–687.CrossRefPubMed

18.

Saegusa H, Momose M, Kawa S, et al. Hilar and pancreatic gallium-67 accumulation is characteristic feature of autoimmune pancreatitis. Pancreas. 2003;27:20–25.CrossRefPubMed

19.

Hamano H, Kawa S, Ochi Y, et al. Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis. Lancet. 2002;359:1403–1404.CrossRefPubMed

20.

Uchiyama-Tanaka Y, Mori Y, Kimura T, et al. Acute tubulointerstitial nephritis associated with autoimmune-related pancreatitis. Am J Kidney Dis. 2004;43:18–25.CrossRef

21.

Hirano K, Kawabe T, Komatsu Y, et al. High-rate pulmonary involvement in autoimmune pancreatitis. Intern Med J. 2006;36:58–61.CrossRefPubMed

22.

Komatsu K, Hamano H, Ochi Y, et al. High prevalence of hypothyroidism in patients with autoimmune pancreatitis. Dig Dis Sci. 2005;50:1052–1057.CrossRefPubMed

23.

Yoshimura Y, Takeda S, Ieki Y, et al. IgG4-associated prostatitis complicating autoimmune pancreatitis. Intern Med. 2006;45:897–901.CrossRefPubMed

24.

Ravi K, Chari ST, Vege SS, et al. Inflammatory bowel disease in the setting of autoimmune pancreatitis. Inflamm Bowel Dis. 2009;15:1326–1330.CrossRefPubMed

25.

Ohara H, Nakazawa T, Sano H, et al. Systemic extrapancreatic lesions associated with autoimmune pancreatitis. Pancreas. 2005;31:232–237.CrossRefPubMed

26.

Kamisawa T, Nakajima H, Egawa N, et al. IgG4-related sclerosing disease incorporating sclerosing pancreatitis, cholangitis, sialadenitis and retroperitoneal fibrosis with lymphadenopathy. Pancreatology. 2006;6:132–137.CrossRefPubMed

27.

Kamisawa T, Okamoto A. Autoimmune pancreatitis; proposal of IgG4-related sclerosing disease. J Gastroenterol. 2006;41:613–625.CrossRefPubMed

28.

Kamisawa T, Funata N, Hayashi Y, et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003;38:982–984.CrossRefPubMed

29.

Kasashima S, Zen Y, Kawashima A, et al. Inflammatory abdominal aortic aneurysm: close relationship to IgG4-related periaortitis. Am J Surg Pathol. 2008;32:197–204.CrossRefPubMed

30.

Yamashita K, Haga H, Kobashi Y, et al. Lung involvement in IgG4-related lymphoplasmacytic vasculitis and interstitial fibrosis. Am J Surg Pathol. 2008;32:1620–1626.CrossRefPubMed

31.

Deshpande V, Chicano S, Finkelberg D, et al. Autoimmune pancreatitis: a systemic immune complex mediated disease. Am J Surg Pathol. 2006;30:1537–1545.CrossRefPubMed

32.

Kojima M, Sipos B, Klapper W, et al. Autoimmune pancreatitis: frequency, IgG4 expression, and clonality of T and B cells. Am J Surg Pathol. 2007;31:521–528.CrossRefPubMed

33.

Zhang L, Notohara K, Levy MJ, et al. IgG4-positive plasma cell infiltration in the diagnosis of autoimmune pancreatitis. Mod Pathol. 2007;20:23–28.CrossRefPubMed

34.

Kawaguchi K, Koike M, Tsuruta K, et al. Lymphoplasmacytic sclerosing pancreatitis with cholangitis: a variant of primary sclerosing cholangitis extensively involving pancreas. Hum Pathol. 1991;22:387–395.CrossRefPubMed

35.

Comings DE, Skubi KB, Van Eyes J, et al. Familial multifocal fibrosclerosis. Findings suggesting that retroperitoneal fibrosis, mediastinal fibrosis, sclerosing cholangitis, Riedel’s thyroiditis, and pseudotumor of the orbit may be different manifestations of a single disease. Ann Intern Med. 1967;66:884–892.PubMed

36.

Clark A, Zeman RK, Choyke PL, et al. Pancreatic pseudotumors associated with multifocal idiopathic fibrosclerosis. Gastrointest Radial. 1988;13:30–32.CrossRef

37.

Jafri SZH, Bree RL, Agha FP, et al. Inflammatory pseudotumor from sclerosing cholangitis. J Comput Assist Tomogr. 1983;7:902–904.CrossRefPubMed

38.

Laitt RD, Hubscher SG, Buckels JA, et al. Sclerosing cholangitis associated with multifocal fibrosis: a case report. Gut. 1992;33:1430–1432.CrossRefPubMed

39.

Levey JM, Mathai J. Diffuse pancreatic fibrosis: an uncommon feature of multifocal idiopathic fibrosclerosis. Am J Gastroenterol. 1998;93:640–642.CrossRefPubMed

40.

Hastier P, Buckley M, Gall Pt, et al. First report of association of chronic pancreatitis, primary biliary cirrhosis, and systemic sclerosis. Dig Dis Sci. 1998;43:2426–2428.CrossRefPubMed

41.

Church NI, Pereira SP, Deheragoda MG, et al. Autoimmune pancreatitis: clinical and radiological features and objective response to steroid therapy in a UK series. Am J Gastroenterol. 2007;102:2417–2425.CrossRefPubMed

42.

Czako L, Hegykozi E, Palinkas A, et al. Autoimmune pancreatitis: functional and morphological recovery after steroid therapy. World J Gastroenterol. 2006;12:1810–1812.PubMed

43.

Erkelens GW, Vleggaar FP, Lesterhuis W, et al. Sclerosing pancreato-cholangitis responsive to steroid therapy. Lancet. 1999;354:43–44.CrossRefPubMed

44.

Gardner TB, Chari ST. Autoimmune pancreatitis. Gastroenterol Clin North Am. 2008;37:439–460.CrossRefPubMed

45.

Chari ST. Current concepts in the treatment of autoimmune pancreatitis. JOP. 2007;8:1–3.PubMed

46.

Members of the Criteria Committee for Autoimmune Pancreatitis of the Japan Pancreas Society. Diagnostic criteria for autoimmune pancreatitis by the Japan Pancreas Society. J Jpn Pan Soc. 2002;17:585–587.

47.

Chari ST, Smyrk TC, Levy MJ, et al. Autoimmune pancreatitis: diagnosis using histology, imaging, serology, other organ involvement and response to steroids. Clin Gastroenterol Hepatol. 2006;4:1010–1016.CrossRefPubMed

48.

Chari ST, Takahashi N, Levy MJ, et al. A diagnostic strategy to distinguish autoimmune pancreatitis from pancreatic cancer. Clin Gastroenterol Hepatol. 2009;7:1097–1103.CrossRefPubMed

49.

Ball WP, Baggenstoss AH, Bargen JA. Pancreatic lesions associated with chronic ulcerative colitis. Arch Pathol (Chic). 1950;50:345–358.

50.

Altman HS, Philips G, Bank S, et al. Pancreatitis associated with duodenal Crohn’s disease. Am J Gastroenterol. 1983;78:174–177.PubMed

51.

Legge DA, Hofman HN, Carlson HC. Pancreatitis as a complication of regional enteritis of the duodenum. Gastroenterology. 1971;61:834–837.PubMed

52.

Barthet M, Hastier P, Bernard JP, et al. Chronic pancreatitis and inflammatory bowel disease: true or coincidental association? Am J Gastroenterol. 1999;94:2141–2148.CrossRefPubMed

53.

Seyrig JA, Jian R, Modigliani R, et al. Idiopathic pancreatitis associated with inflammatory bowel disease. Dig Dis Sci. 1985;30:1121–1126.CrossRefPubMed

54.

Hegnhoj J, Hansen CP, Rannem T, et al. Pancreatic function in Crohn’s disease. Gut. 1990;31:1076–1079.CrossRefPubMed

55.

Heikius B, Niemela S, Lehtola J, et al. Pancreatic duct abnormalities and pancreatic function in patients with chronic inflammatory bowel disease. Scand J Gastroenterol. 1996;31:517–523.CrossRefPubMed

56.

Katz S, Bank S, Greenberg RE, et al. Hyperamylasemia in inflammatory bowel disease. J Clin Gastroenterol. 1988;10:627–630.CrossRefPubMed

Title: IgG4-Related Sclerosing Disease: A Novel Mimic of Inflammatory Bowel Disease
Authors: Neeraj Narula
Monica Vasudev
John K. Marshall
Publication date: 01-11-2010
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 11/2010
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-010-1287-1

ACC 2024 Congress Coverage

Heart Failure Video

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

IgG₄-Related Sclerosing Disease: A Novel Mimic of Inflammatory Bowel Disease

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 11/2010

EUS and ERCP Complication Rates Are Not Increased in Elderly Patients

Obese Women vs. Obese Men: Risk Factor for Colorectal Neoplasia

Celiac Disease: Similar Presentations in the Elderly and Young Adults

Significance of Palisading Longitudinal Esophagus Vessels: Identification of the True Esophagogastric Junction Has Histopathological and Oncological Considerations

Hepatic Angiomyolipoma: A Clinical Experience in Diagnosis and Treatment

Risk of Non-melanoma Skin Cancer in Autoimmune Hepatitis

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page