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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 11/2010

01-11-2010 | Correspondence

Obese Women vs. Obese Men: Risk Factor for Colorectal Neoplasia

Author: Tarun Rustagi

Published in: Digestive Diseases and Sciences | Issue 11/2010

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Excerpt

Obesity has been increasingly recognized as a risk factor for gastrointestinal diseases including Barrett’s, esophageal cancer and nonalcoholic fatty liver disease [1‐3]. Recent American College of Gastroenterology Guidelines for colorectal cancer (CRC) screening recommend that initiation of screening at an earlier age may be beneficial and cost-effective in obese patients [4]. A meta-analysis of six studies estimated a 3% increase (95% confidence interval [CI] 2–4) in CRC risk per one unit increase in body-mass index (BMI) [5]. The risk of CRC for obese patients compared with that for non-obese patients is increased by 1.5–2.8 folds, and is particularly associated with high-risk adenomas [4]. …
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Wong A, Fitzgerald RC. Epidemiologic risk factors for Barrett’s esophagus and associated adenocarcinoma. Clin Gastroenterol Hepatol. 2005;3:1–10.CrossRefPubMed
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Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006; 43(2 suppl 1):S99–S112.
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Rex DK, Johnson DA, Anderson JC, Schoenfeld PS, Burke CA, Inadomi JM. American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected]. Am J Gastroenterol. 2009;104(3):739–750.CrossRefPubMed
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Bergstrom A, Pisani P, Tenet V, et al. Overweight as an avoidable cause of cancer in Europe. Int J Cancer. 2001;91:421–430.CrossRefPubMed
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Stein B, Anderson JC, Rajapakse R, Alpern ZA, Messina CR, Walker G. Body mass index as a predictor of colorectal neoplasia in ethnically diverse screening population. Dig Dis Sci. doi:10.​1007/​s10620-009-1113-9.
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Anderson JC, Messina CR, Dakhllalah F, et al. Body mass index: a marker for significant colorectal neoplasia in a screening population. J Clin Gastroenterol. 2007;41(3):285–290.CrossRefPubMed
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Lieberman DA, Prindiville S, Weiss DG, et al. Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals. JAMA. 2003;290:2959–2967.CrossRefPubMed
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Cash B, Flood A, Weiss DG et al. Risk factors for advanced colorectal neoplasia in women: comparison of the concern and VA 380 populations [abstract]. Gastroenterology. 2006;130:A–186.
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Dai Z, Xu YC, Niu L. Obesity and colorectal cancer risk: a metaanalysis of cohort studies. World J Gastroenterol. 2007;13(31):4199–4206.PubMed
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Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr. 2001;131:3109S–3120S.PubMed
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Gunter MJ, Leitzmann MF. Obesity and colorectal cancer: epidemiology, mechanisms and candidate genes. J Nutr Biochem. 2006;17:145–156.CrossRefPubMed
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Moore LL, Bradlee ML, Singer MR, et al. BMI and waist circumference as predictors of lifetime colon cancer risk in Framingham Study adults. Int J Obes Relat Metab Disord. 2004;28(4):559–567.CrossRefPubMed
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Ludescher B, Machann J, Eschweiler GW, Vanhofen S, Maenz C, Thamer C, Claussen CD, Schick F. Correlation of fat distribution in whole body MRI with generally used anthropometric data. Invest Radiol 2009;44:712-9CrossRefPubMed
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Roy HK, Bianchi LK. Differences in colon adenomas and carcinomas among women and men: potential clinical implications. JAMA 2009;302:1696-7.CrossRefPubMed
Metadata
Title
Obese Women vs. Obese Men: Risk Factor for Colorectal Neoplasia
Author
Tarun Rustagi
Publication date
01-11-2010
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 11/2010
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-010-1244-z

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