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Published in:

01-12-2012

MicroRNA control of epithelial–mesenchymal transition and metastasis

Authors: Jinsong Zhang, Li Ma

Published in: Cancer and Metastasis Reviews | Issue 3-4/2012

Abstract

The great majority of cancer deaths are due to metastasis, which remains a poorly understood pathological process. The formation of a metastasis reflects a succession of complex steps leading to the macroscopic outgrowth of disseminated tumor cells at the secondary site. In the past 5 years, certain microRNAs (miRNAs) have been shown to regulate either a single step or multiple steps of metastasis, doing so by downregulating the expression of their target genes. In this review, we discuss recent studies on the functions and molecular mechanisms of miRNAs in regulating epithelial–mesenchymal transition (EMT) and cancer metastasis.

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Title: MicroRNA control of epithelial–mesenchymal transition and metastasis
Authors: Jinsong Zhang
Li Ma
Publication date: 01-12-2012
Publisher: Springer US
Published in: Cancer and Metastasis Reviews / Issue 3-4/2012
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-012-9368-6

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