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Angiogenesis
Published in: Angiogenesis 1/2013

01-01-2013 | Review Paper

Endothelialization approaches for viable engineered tissues

Authors: Silvia Baiguera, Domenico Ribatti

Published in: Angiogenesis | Issue 1/2013

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Abstract

One of the main limitation in obtaining thick, 3-dimensional viable engineered constructs is the inability to provide a sufficient and functional blood vessel system essential for the in vitro survival and the in vivo integration of the construct. Different strategies have been proposed to simulate the ingrowth of new blood vessels into engineered tissue, such as the use of growth factors, fabrication scaffold technologies, in vivo prevascularization and cell-based strategies, and it has been demonstrated that endothelial cells play a central role in the neovascularization process and in the control of blood vessel function. In particular, different “environmental” settings (origin, presence of supporting cells, biomaterial surface, presence of hemodynamic forces) strongly influence endothelial cell function, angiogenic potential and the in vivo formation of durable vessels. This review provides an overview of the different techniques developed so far for the vascularization of tissue-engineered constructs (with their advantages and pitfalls), focusing the attention on the recent development in the cell-based vascularization strategy and the in vivo applications.
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Metadata
Title
Endothelialization approaches for viable engineered tissues
Authors
Silvia Baiguera
Domenico Ribatti
Publication date
01-01-2013
Publisher
Springer Netherlands
Published in
Angiogenesis / Issue 1/2013
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-012-9307-8

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