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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-02-2019 | Research Article

Toward ¹⁹F magnetic resonance thermometry: spin–lattice and spin–spin-relaxation times and temperature dependence of fluorinated drugs at 9.4 T

Authors: Christian Prinz, Paula Ramos Delgado, Thomas Wilhelm Eigentler, Ludger Starke, Thoralf Niendorf, Sonia Waiczies

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2019

Abstract

Objective

This study examines the influence of the environmental factor temperature on the ¹⁹F NMR characteristics of fluorinated compounds in phantom studies and in tissue.

Materials and methods

¹⁹F MR mapping and MR spectroscopy techniques were used to characterize the ¹⁹F NMR characteristics of perfluoro-crown ether (PFCE), isoflurane, teriflunomide, and flupentixol. T₁ and T₂ mapping were performed, while temperature in the samples was changed (T = 20–60 °C) and monitored using fiber optic measurements. In tissue, T₁ of PFCE nanoparticles was determined at physiological temperatures and compared with the T_1-measured at room temperature.

Results

Studies on PFCE, isoflurane, teriflunomide, and flupentixol showed a relationship between temperature and their physicochemical characteristics, namely, chemical shift, T₁ and T₂. T₁ of PFCE nanoparticles was higher at physiological body temperatures compared to room temperature.

Discussion

The impact of temperature on the ¹⁹F NMR parameters of fluorinated compounds demonstrated in this study not only opens a trajectory toward ¹⁹F MR-based thermometry, but also indicates the need for adapting MR sequence parameters according to environmental changes such as temperature. This will be an absolute requirement for detecting fluorinated compounds by ¹⁹F MR techniques in vivo.

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Title: Toward 19F magnetic resonance thermometry: spin–lattice and spin–spin-relaxation times and temperature dependence of fluorinated drugs at 9.4 T
Authors: Christian Prinz
Paula Ramos Delgado
Thomas Wilhelm Eigentler
Ludger Starke
Thoralf Niendorf
Sonia Waiczies
Publication date: 01-02-2019
Publisher: Springer International Publishing
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2019
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-018-0722-8

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Toward ¹⁹F magnetic resonance thermometry: spin–lattice and spin–spin-relaxation times and temperature dependence of fluorinated drugs at 9.4 T

Abstract

Objective

Materials and methods

Results

Discussion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Materials and methods

Results

Discussion

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