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01-02-2020 | Vaccination | Review

Anal squamous intraepithelial lesions: an update and proposed management algorithm

Authors: T. Chittleborough, R. Tapper, T. Eglinton, Frank Frizelle

Published in: Techniques in Coloproctology | Issue 2/2020

Abstract

The term anal squamous intraepithelial lesion (ASIL) is used to describe premalignant change of anal squamous cells that precede the development of squamous cell carcinoma. Pathophysiology is driven by the human papilloma virus (HPV), and progression and regression of ASIL being well described, with 12% of high-grade lesions progressing to invasive cancer within 5 years. Vaccination against HPV is effective for primary prevention. Management consists of identification and treatment of high-grade lesions to prevent progression to squamous cell carcinoma. Management of established ASIL aims to avoid the progression to invasive cancer and maintain fecal continence. A combination of surveillance, excision, ablative, or topical therapies is used to achieve this. The aim of the present study was to review the contemporary evidence about ASIL and to suggest a management algorithm.

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Title: Anal squamous intraepithelial lesions: an update and proposed management algorithm
Authors: T. Chittleborough
R. Tapper
T. Eglinton
Frank Frizelle
Publication date: 01-02-2020
Publisher: Springer International Publishing
Keywords: Vaccination
Human Immunodeficiency Virus
Anal Cancer
Anal Cancer
Published in: Techniques in Coloproctology / Issue 2/2020
Print ISSN: 1123-6337
Electronic ISSN: 1128-045X
DOI: https://doi.org/10.1007/s10151-019-02133-4

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Anal squamous intraepithelial lesions: an update and proposed management algorithm

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