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European Journal of Clinical Microbiology & Infectious Diseases

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01-09-2020 | Escherichia Coli | Letter to the Editor

Activity of temocillin and comparators against urinary Escherichia coli and Klebsiella pneumoniae from Iran

Authors: Mohammad Rahbar, Sébastien Van de Velde, Parisa Eslami, Masoud Mardani

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 9/2020

Abstract

To evaluate the ground susceptibility of urinary Escherichia coli and Klebsiella pneumoniae to temocillin, the susceptibility of temocillin and comparators against 500 clinical isolates (231 E. coli and 269 K. pneumoniae) was tested. Temocillin was either found as the most active antibiotic (susceptibility rate of 92%) or the fourth most active antibiotic (65%), as per its urinary and systemic breakpoint, respectively. No difference of activity was observed in isolates expressing ESBL/AmpC enzymes. Considering the percentage of isolates expressing beta-lactamases and the need to spare broad-spectrum antibiotics, temocillin seems promising for treating urinary tract infections.

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Title: Activity of temocillin and comparators against urinary Escherichia coli and Klebsiella pneumoniae from Iran
Authors: Mohammad Rahbar
Sébastien Van de Velde
Parisa Eslami
Masoud Mardani
Publication date: 01-09-2020
Publisher: Springer Berlin Heidelberg
Keywords: Escherichia Coli
Ciprofloxacin
Gentamicin
Antibiotic
Piperacillin
Meropenem
Amoxicillin
Ceftriaxone
Ceftazidime
Urinary Tract Infection
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 9/2020
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-020-03898-5

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