Top

Published in:

01-08-2020 | Frontotemporal Dementia | Original Article

Insight in frontotemporal dementia and progressive supranuclear palsy

Authors: Andrea Plutino, Emanuele Camerucci, Valentina Ranaldi, Sara Baldinelli, Chiara Fiori, Mauro Silvestrini, Simona Luzzi

Published in: Neurological Sciences | Issue 8/2020

Abstract

Introduction

Progressive supranuclear palsy (PSP) and behavioural variant frontotemporal dementia – (bv-FTD) share common neuropsychological features except for online monitoring awareness. Therefore, the aim of our study is to explore if this assessment could be used in standard clinical practice.

Materials and methods

We retrospectively analyse 93 subjects (27 FTD, 25 PSP, 42 healthy controls). Neuropsychological and instrumental examinations were performed for each patient.

Results

FTD patients made fewer self-corrections than PSP patients despite a similar number of total errors. We also performed ROC curves: the area under the curve (AUC) is 0.79. A model for a logistic regression was also developed: the only significant predictor is the number of self-corrections (p = 0.004 β = 1244).

Discussion and conclusions

In conclusion, our findings show online awareness is more compromised in FTD patients than in PSP patients. This difference could be useful for making a differential diagnosis between the two diseases: for each extra point in number of self-corrections the probability of suffering from PSP increases by about three and a half times (OR 3.47).

Wider C, Wszolek ZK (2008) Etiology and Pathophysiology of Frontotemporal Dementia , Parkinson Disease and Alzheimer Disease : Lessons from Genetic Studies. Neurodegener Dis 32224:122–125. https://doi.org/10.1159/000113680 CrossRef

Rascovsky K, Hodges JRJR, Knopman D et al (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134(Pt 9):2456–2477. https://doi.org/10.1093/Brain/Awr179 PubMedPubMedCentralCrossRef

Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten J, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I, Movement Disorder Society-endorsed PSP Study Group (2017) Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord 32(6):853–864. https://doi.org/10.1002/mds.26987 PubMedPubMedCentralCrossRef

Gordon E, Rohrer JD, Fox NC (2016) Advances in neuroimaging in frontotemporal dementia. J Neurochem 138:193–210. https://doi.org/10.1111/jnc.13656 PubMedCrossRef

Stezin A, Lenka A, Jhunjhunwala K, Saini J, Pal PK (2017) Advanced structural neuroimaging in progressive supranuclear palsy: where do we stand? Parkinsonism Relat Disord 36:19–32. https://doi.org/10.1016/j.parkreldis.2016.12.023 PubMedCrossRef

Libon DJ, Xie SX, Moore P, Farmer J, Antani S, McCawley G, Cross K, Grossman M (2007) Patterns of neuropsychological impairment in frontotemporal dementia. Neurology. 68(5):369–375. https://doi.org/10.1212/01.wnl.0000252820.81313.9b PubMedCrossRef

Dubois B, Pillon B (2005) Added Value of the Neuropsychological Evaluation for Diagnosis and Research of Atypical Parkinsonian Disorders. https://doi.org/10.1385/1-59259-834-X:185

Diamond A (2013) Executive functions. Annu Rev Psychol 64:135–168. https://doi.org/10.1146/annurev-psych-113011-143750 PubMedCrossRef

Lagarde J, Valabrègue R, Corvol JC, Pineau F, le Ber I, Vidailhet M, Dubois B, Levy R (2013) Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study. PLoS One 8(11):1–10. https://doi.org/10.1371/journal.pone.0080353 CrossRef

10.

Kobylecki C, Jones M, Thompson JC, Richardson AM, Neary D, Mann DM, Snowden JS, Gerhard A (2015) Cognitive–behavioural features of progressive supranuclear palsy syndrome overlap with frontotemporal dementia. J Neurol 262(4):916–922. https://doi.org/10.1007/s00415-015-7657-z PubMedCrossRef

11.

Harciarek M, Cosentino S (2013) Language, executive function and social cognition in the diagnosis of frontotemporal dementia syndromes. Int Rev Psychiatry 25(2):178–196. https://doi.org/10.3109/09540261.2013.763340 PubMedPubMedCentralCrossRef

12.

O’Keeffe FM, Murray B, Coen RF et al (2007) Loss of insight in frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy. Brain. 130(3):753–764. https://doi.org/10.1093/brain/awl367 PubMedCrossRef

13.

Levy S, Gansler D, Huey E et al (2017) Assessment of Patient Self-awareness and Related Neural Correlates in Frontotemporal Dementia and Corticobasal Syndrome. Arch Clin Neuropsychol October:1–11. https://doi.org/10.1093/arclin/acx105 CrossRef

14.

Morris RG, Mograbi DC (2013) Anosognosia, autobiographical memory and self knowledge in Alzheimer’s disease. Cortex. 49(6):1553–1565. https://doi.org/10.1016/j.cortex.2012.09.006 PubMedCrossRef

15.

Agnew SK, Morris RG (1998) The heterogeneity of anosognosia for memory impairment in Alzheimer s disease: a review of the literature and a proposed model. Aging Ment Health 2(1):7–19CrossRef

16.

Toglia JP, Kirk U (2000) Understanding awareness deficits following brain injury. Neuro Rehabil 15(1):57–70 http://www.ncbi.nlm.nih.gov/pubmed/11455082

17.

Anderson SW, Tranel D (1989) Awareness of disease states following cerebral infarction, dementia, and head trauma: standardized assessment. Clin Neuropsychol 3(4):327–339. https://doi.org/10.1080/13854048908401482 CrossRef

18.

Bullard SE, Griss M, Greene S, Gekker A (2013) Encyclopedia of Clinical Neuropsychology, vol 28. https://doi.org/10.1093/arclin/acs103 CrossRef

19.

O’Keeffe FM, Dockree PM, Robertson IH (2004) Poor insight in traumatic brain injury mediated by impaired error processing? Cogn Brain Res 22(1):101–112. https://doi.org/10.1016/j.cogbrainres.2004.07.012 CrossRef

20.

Garavan H, Ross TJ, Murphy K, Roche RAP, Stein EA (2002) Dissociable executive functions in the dynamic control of behavior: inhibition, error detection, and correction. Neuroimage. 17(4):1820–1829. https://doi.org/10.1006/nimg.2002.1326 PubMedCrossRef

21.

Miller AK (2010) Examining the errors and self-corrections on the Stroop test. http://engagedscholarship.csuohio.edu/etdarchive. Accessed 11 Sept 2019

22.

Brugnolo A, De Carli F, Accardo J et al (2016) An updated Italian normative dataset for the Stroop color word test (SCWT). Neurol Sci 37(3):365–372. https://doi.org/10.1007/s10072-015-2428-2 PubMedCrossRef

23.

Ham TE, Bonnelle V, Hellyer P, Jilka S, Robertson IH, Leech R, Sharp DJ (2014) The neural basis of impaired self-awareness after traumatic brain injury. Brain. 137(2):586–597. https://doi.org/10.1093/brain/awt350 PubMedCrossRef

24.

Boxer AL, Belfor N, Gorno-Tempini ML et al (2006) Patterns of brain atrophy that differentiate Corticobasal degeneration syndrome from progressive Supranuclear palsy. Arch Neurol 63(1):81–86. https://doi.org/10.1001/archneur.63.1.81 PubMedCrossRef

25.

Atiya M, Hyman BT, Albert MS, Killiany R (2003) Structural magnetic resonance imaging in established and prodromal Alzheimer disease: a review. Alzheimer Dis Assoc Disord 17(3):177–195. https://doi.org/10.1097/00002093-200307000-00010 PubMedCrossRef

26.

Canu E, Agosta F, Mandic-Stojmenovic G, Stojković T, Stefanova E, Inuggi A, Imperiale F, Copetti M, Kostic VS, Filippi M (2017) Multiparametric MRI to distinguish early onset Alzheimer’s disease and behavioural variant of frontotemporal dementia. NeuroImage Clin 15(March):428–438. https://doi.org/10.1016/j.nicl.2017.05.018 PubMedPubMedCentralCrossRef

27.

Magni E, Binetti G, Bianchetti A, Rozzini R, Trabucchi M (1996) Mini-mental state examination: a normative study in Italian elderly population. Eur J Neurol 3(3):198–202PubMedCrossRef

28.

Weiner MF, Hynan LS, Rossetti H, Falkowski J (2011) Luria’s three-step test: what is it and what does it tell us ? Int Psychogeriatr 23(10):1602–1606. https://doi.org/10.1017/S1041610211000767 PubMedPubMedCentralCrossRef

29.

Carlesimo GA, Caltagirone C, Gainotti G et al (1996) The mental deterioration battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment. Eur Neurol 36:378–384PubMedCrossRef

30.

Measso G, Zappalà G, Cavarzeran F, Crook TH, Romani L, Pirozzolo FJ, Grigoletto F, Amaducci LA, Massari D, Lebowitz BD (1993) Raven’s colored progressive matrices: a normative study of a random sample of healthy adults. Acta Neurol Scand 88(1):70–74. https://doi.org/10.1111/j.1600-0404.1993.tb04190.x PubMedCrossRef

31.

Scarpina F, Tagini S (2017) The stroop color and word test. Front Psychol 8(APR):1–8. https://doi.org/10.3389/fpsyg.2017.00557 CrossRef

32.

Monaco M, Costa A, Caltagirone C, Carlesimo GA (2013) Forward and backward span for verbal and visuo-spatial data: standardization and normative data from an Italian adult population. Neurol Sci 34(5):749–754. https://doi.org/10.1007/s10072-012-1130-x PubMedCrossRef

33.

Luzzi S, Pesallaccia M, Fabi K, Muti M, Viticchi G, Provinciali L, Piccirilli M (2011) Non-verbal memory measured by rey-osterrieth complex figure B: normative data. Neurol Sci 32(6):1081–1089. https://doi.org/10.1007/s10072-011-0641-1 PubMedCrossRef

34.

Snodgrass JG, Vanderwart M (1980) A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J Exp Psychol Hum Learn Mem 6(2):174–215. https://doi.org/10.1109/ICIP.2001.958943 CrossRef

35.

Snowden JS, Thompson JC, Neary D (2004) Knowledge of famous faces and names in semantic dementia. Brain. 127(4):860–872. https://doi.org/10.1093/brain/awh099 PubMedCrossRef

36.

Zarino B, Crespi M, Launi M, Casarotti A (2014) A new standardization of semantic verbal fluency test. Neurol Sci 35(9):1405–1411. https://doi.org/10.1007/s10072-014-1729-1 PubMedCrossRef

37.

De Renzi E, Pieczuro A, Vignolo LA (1968) Ideational apraxia: A quantitative study. Neuropsychologia. 6(1):41–52. https://doi.org/10.1016/0028-3932(68)90037-7 CrossRef

38.

Della Sala S, Laiacona M, Trivelli C, Spinnler H (1995) Poppelreuter-Ghent’s overlapping figures test: its sensitivity to age, and its clinical use. Arch Clin Neuropsychol 10(6):511–534. https://doi.org/10.1016/0887-6177(94)00049-V PubMedCrossRef

39.

Evers K, Kilander L, Lindau M (2007) Insight in frontotemporal dementia: conceptual analysis and empirical evaluation of the consensus criterion “loss of insight” in frontotemporal dementia. Brain Cogn 63(1):13–23. https://doi.org/10.1016/j.bandc.2006.07.001 PubMedCrossRef

40.

Rankin KP, Baldwin E, Pace-Savitsky C, Kramer JH, Miller BL (2005) Self awareness and personality change in dementia. J Neurol Neurosurg Psychiatry 76(5):632–639. https://doi.org/10.1136/jnnp.2004.042879 PubMedPubMedCentralCrossRef

41.

Smith D, Lovell J, Weller C, Kennedy B, Winbolt M, Young C, Ibrahim J (2017) A systematic review of medication nonadherence in persons with dementia or cognitive impairment. PLoS One 12(2):1–19. https://doi.org/10.1371/journal.pone.0170651 CrossRef

Title: Insight in frontotemporal dementia and progressive supranuclear palsy
Authors: Andrea Plutino
Emanuele Camerucci
Valentina Ranaldi
Sara Baldinelli
Chiara Fiori
Mauro Silvestrini
Simona Luzzi
Publication date: 01-08-2020
Publisher: Springer International Publishing
Keywords: Frontotemporal Dementia
Frontotemporal Dementia
Dementia
Dementia
Progressive Supranuclear Palsy
Published in: Neurological Sciences / Issue 8/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04290-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Insight in frontotemporal dementia and progressive supranuclear palsy

Abstract

Introduction

Materials and methods

Results

Discussion and conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Materials and methods

Results

Discussion and conclusions

Please log in to get access to this content

Other articles of this Issue 8/2020

Type B diencephalic–mesencephalic junction dysplasia, a congenital brainstem malformation that may be silent until adulthood: a case report

Management of COVID-19 in people with epilepsy: drug considerations

Ultrasound assessment of diaphragm function in patients with late-onset Pompe disease

Informing MS patients on treatment options: a consensus on the process of consent taking

Electroencephalography at the time of Covid-19 pandemic in Italy

Exacerbation of myasthenia gravis after amoxicillin therapy: a case series