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Neurological Sciences
Published in: Neurological Sciences 6/2019

01-06-2019 | Central Nervous System Trauma | Review Article

Intestinal barrier dysfunction following traumatic brain injury

Authors: Pengfei Pan, Yunlin Song, Xinxin Du, Linlin Bai, Xiaoli Hua, Yawen Xiao, Xiangyou Yu

Published in: Neurological Sciences | Issue 6/2019

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Abstract

Traumatic brain injury (TBI) can cause non-neurological injuries to other organs such as the intestine. Newer studies have shown that paracellular hyperpermeability is the basis of intestinal barrier dysfunction following TBI. Ischemia–reperfusion injury, inflammatory response, abnormal release of neurotransmitters and hormones, and malnutrition contribute to TBI-induced intestinal barrier dysfunction. Several interventions that may protect intestinal barrier function and promote the recovery of TBI have been proposed, but relevant studies are still limited. This review is to clarify the established mechanisms of intestinal barrier dysfunction following TBI and to describe the possible strategies to reduce or prevent intestinal barrier dysfunction.
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Metadata
Title
Intestinal barrier dysfunction following traumatic brain injury
Authors
Pengfei Pan
Yunlin Song
Xinxin Du
Linlin Bai
Xiaoli Hua
Yawen Xiao
Xiangyou Yu
Publication date
01-06-2019
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 6/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-019-03739-0

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