Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Archives of Virology
Published in: Archives of Virology 3/2024

01-03-2024 | Leukemia | Brief Report

Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis

Authors: Naganori Nao, Tomohiro Okagawa, Naomi Nojiri, Satoru Konnai, Honami Shimakura, Misono Tominaga, Hazuka Yoshida-Furihata, Eri Nishiyama, Takahiro Matsudaira, Naoya Maekawa, Shiro Murata, Masamichi Muramatsu, Kazuhiko Ohashi, Masumichi Saito

Published in: Archives of Virology | Issue 3/2024

Login to get access

Abstract

Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3–9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.
Appendix
Available only for authorised users
Literature
1.
Rosewick N, Durkin K, Artesi M, Marçais A, Hahaut V, Griebel P et al (2017) Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis. Nat Commun 8:15264ADSCrossRefPubMedPubMedCentral
2.
3.
Khatami A, Pormohammad A, Farzi R, Saadati H, Mehrabi M, Kiani SJ et al (2020) Bovine leukemia virus (BLV) and risk of breast cancer: a systematic review and meta-analysis of case-control studies. Infect Agent Cancer 15:48CrossRefPubMedPubMedCentral
4.
Gillet NA, Willems L (2016) Whole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA. Retrovirology 13(1):75CrossRefPubMedPubMedCentral
5.
Wada Y, Sato T, Hasegawa H, Matsudaira T, Nao N, Coler-Reilly ALG et al (2022) RAISING is a high-performance method for identifying random transgene integration sites. Commun Biol 5(1):535CrossRefPubMedPubMedCentral
6.
Okagawa T, Shimakura H, Konnai S, Saito M, Matsudaira T, Nao N et al (2022) Diagnosis and early prediction of lymphoma using high-throughput clonality analysis of bovine leukemia virus-infected cells. Microbiol Spectr 10(6):e0259522CrossRefPubMed
7.
8.
Mansky LM (1998) Retrovirus mutation rates and their role in genetic variation. The J Gen Virol 79(Pt 6):1337–1345CrossRefPubMed
9.
Jetzt AE, Yu H, Klarmann GJ, Ron Y, Preston BD, Dougherty JP (2000) High rate of recombination throughout the human immunodeficiency virus type 1 genome. J Virol 74(3):1234–1240CrossRefPubMedPubMedCentral
10.
Jung A, Maier R, Vartanian JP, Bocharov G, Jung V, Fischer U et al (2002) Recombination: Multiply infected spleen cells in HIV patients. Nature 418(6894):144ADSCrossRefPubMed
11.
Bushman F, Lewinski M, Ciuffi A, Barr S, Leipzig J, Hannenhalli S et al (2005) Genome-wide analysis of retroviral DNA integration. Nat Rev Microbiol 3(11):848–858CrossRefPubMed
12.
Kawamura M, Umehara D, Odahara Y, Miyake A, Ngo MH, Ohsato Y et al (2017) AKT capture by feline leukemia virus. Arch Virol 162(4):1031–1036CrossRefPubMed
13.
Roberts AB, Flanders KC, Heine UI, Jakowlew S, Kondaiah P, Kim SJ et al (1990) Transforming growth factor-beta: multifunctional regulator of differentiation and development. Philos Trans R Soc Lond B Biol Sci 327(1239):145–154ADSCrossRefPubMed
14.
Kim SY, Zhu J, Woodruff TK (2011) A truncated, activin-induced Smad3 isoform acts as a transcriptional repressor of FSHbeta expression in mouse pituitary. Mol Cell Endocrinol 342(1–2):64–72CrossRefPubMedPubMedCentral
15.
Chen CR, Kang Y, Siegel PM, Massague J (2002) E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell 110(1):19–32CrossRefPubMed
16.
Korac P, Dotlic S, Matulic M, Zajc Petranovic M, Dominis M (2017) Role of MYC in B Cell Lymphomagenesis. Genes (Basel). ;8(4)
17.
Li X, Wang W, Xi Y, Gao M, Tran M, Aziz KE et al (2016) FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis. Cell Rep 16(2):487–497CrossRefPubMedPubMedCentral
Metadata
Title
Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis
Authors
Naganori Nao
Tomohiro Okagawa
Naomi Nojiri
Satoru Konnai
Honami Shimakura
Misono Tominaga
Hazuka Yoshida-Furihata
Eri Nishiyama
Takahiro Matsudaira
Naoya Maekawa
Shiro Murata
Masamichi Muramatsu
Kazuhiko Ohashi
Masumichi Saito
Publication date
01-03-2024
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 3/2024
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-024-05970-3

Other articles of this Issue 3/2024

Archives of Virology 3/2024 Go to the issue

Original Article

Generation of porcine circovirus type 4 virus-like particles and their use to detect serum antibodies

Annotated Sequence Record

Genomic characterization of a novel cytorhabdovirus infecting Ixeris denticulata in China

Annotated Sequence Record

The complete genome sequence of a putative novel cytorhabdovirus identified in Chelidonium majus in China

Brief Report

First evidence of lumpy skin disease in mithun (Bos frontalis) in India

Original Article

Identification and characterization of a marine bacterium extract from Mameliella sp. M20D2D8 with antiviral effects against influenza A and B viruses

Original Article

Characterization of cleavage patterns and assembly of N-terminally modified GII.6 norovirus VP1 proteins
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits