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01-04-2017 | Brief Report

AKT capture by feline leukemia virus

Authors: Maki Kawamura, Daigo Umehara, Yuka Odahara, Ariko Miyake, Minh Ha Ngo, Yoshiharu Ohsato, Masaharu Hisasue, Masa-aki Nakaya, Shinya Watanabe, Kazuo Nishigaki

Published in: Archives of Virology | Issue 4/2017

Abstract

Oncogene-containing retroviruses are generated by recombination events between viral and cellular sequences, a phenomenon called “oncogene capture”. The captured cellular genes, referred to as “v-onc” genes, then acquire new oncogenic properties. We report a novel feline leukemia virus (FeLV), designated “FeLV–AKT”, that has captured feline c-AKT1 in feline lymphoma. FeLV–AKT contains a gag–AKT fusion gene that encodes the myristoylated Gag matrix protein and the kinase domain of feline c-AKT1, but not its pleckstrin homology domain. Therefore, it differs structurally from the v-Akt gene of murine retrovirus AKT8. AKT may be involved in the mechanisms underlying malignant diseases in cats.

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Title: AKT capture by feline leukemia virus
Authors: Maki Kawamura
Daigo Umehara
Yuka Odahara
Ariko Miyake
Minh Ha Ngo
Yoshiharu Ohsato
Masaharu Hisasue
Masa-aki Nakaya
Shinya Watanabe
Kazuo Nishigaki
Publication date: 01-04-2017
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 4/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-016-3192-1

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