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01-12-2019 | Dengue Virus | Review

Oxidative stress response in the pathogenesis of dengue virus virulence, disease prognosis and therapeutics: an update

Authors: Agieshkumar Balakrishna Pillai, Krishna Raja Muthuraman, Vignesh Mariappan, Srisha Srivatsan Belur, S. Lokesh, Soundravally Rajendiran

Published in: Archives of Virology | Issue 12/2019

Abstract

Dengue virus (DENV) is a mosquito-borne arbovirus that causes febrile illness and can lead to a potentially lethal disease. The mechanism of disease pathogenesis is not completely understood, and there are currently no vaccines or therapeutic drugs available to protect against all four serotypes of DENV. Although many reasons have been suggested for the development of the disease, dengue studies have shown that, during DENV infection, there is an imbalance between oxidants and antioxidants that disrupts homeostasis. An increase in reactive oxygen species (ROS) levels triggers the sudden release of cytokines, which can lead to plasma leakage and other severe symptoms. In the present review, we give an overview of the oxidative stress response and its effect on the progression of dengue disease. We also discuss the role of oxidative-stress-associated molecules in disease prognostic and therapeutics.

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Title: Oxidative stress response in the pathogenesis of dengue virus virulence, disease prognosis and therapeutics: an update
Authors: Agieshkumar Balakrishna Pillai
Krishna Raja Muthuraman
Vignesh Mariappan
Srisha Srivatsan Belur
S. Lokesh
Soundravally Rajendiran
Publication date: 01-12-2019
Publisher: Springer Vienna
Keyword: Dengue Virus
Published in: Archives of Virology / Issue 12/2019
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-019-04406-7

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Oxidative stress response in the pathogenesis of dengue virus virulence, disease prognosis and therapeutics: an update

Abstract

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Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

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Abstract

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