Top

Published in:

Open Access 01-08-2019 | Dengue Virus | Brief Report

The analysis of clinical and laboratory data: a large outbreak of dengue fever in Chaozhou, Guangdong province, China

Authors: Fen Lin, Hui Yang, Lin Zhang, Sen-Hai Fang, Xiao-Fen Zhan, Li-Ye Yang

Published in: Archives of Virology | Issue 8/2019

Abstract

A large-scale dengue fever (DF) outbreak occurred in Chaozhou, Guangdong province, China 2015. In our study, 528 dengue-positive patient samples were collected for clinical and laboratory data analysis. 491 cases (93.0%) were primary dengue fever (PDF), 22 cases (4.2%) were dengue hemorrhagic fever (DHF) and 15 cases (2.8%) were diagnosed with severe dengue fever (SDF). All cases were infected by dengue virus serotype 2 (DENV-2), and the isolated strains belonged to cosmopolitan genotype, which were grouped closely with Malaysia strains from 2010 to 2014. Moreover, the study showed that laboratory indices have significantly difference in PDF, DHF and SDF patients. A comprehensive analysis of these data could assist and guide the clinical diagnosis for DF, which has an important significance for the control of dengue virus infection.

Heilman JM, De Wolff J, Beards GM, Basden BJ (2010) Dengue fever: a Wikipedia clinical review. Open Med 8(4):e105–e115

Whitehorn J, Farrar J (2010) Dengue. Br Med Bull 95:161–173CrossRefPubMed

Guo C, Zhou Z, Wen Z, Liu Y, Zeng C, Xiao D, Ou M, Han Y, Huang S, Liu D, Ye X, Zou X, Wu J, Wang H, Zeng EY, Jing C, Yang G (2017) Global epidemiology of dengue outbreaks in 1990–2015: a systematic review and meta-analysis. Front Cell Infect Microbiol 12(7):317CrossRef

Chen R, Han GZ (2016) Dengue in China: comprehensive phylogenetic evaluation reveals evidence of endemicity and complex genetic diversity. Am J Trop Med Hyg 94(1):198–202CrossRefPubMedCentralPubMed

Guo R, Peng Z, Song T, He J, Zhong H, Li L, Liang W (2014) Current infection status and epidemic risk analysis of Dengue fever and Chikungunya in Guangdong province, from 1990 to 2012. Zhong hua Liu Xing Bing Xue Za Zhi 35(2):167–169

Guo RN, Lin JY, Li LH, Ke CW, He JF, Zhong HJ, Zhou HQ, Peng ZQ, Yang F, Liang WJ (2014) The prevalence and endemic nature of dengue infections in Guangdong, South China: an epidemiological, serological, and etiological study from 2005–2011. PLoS One 9(1):e85596. https://doi.org/10.1371/journal.pone.0085596 CrossRefPubMedCentralPubMed

World Health Organization (WHO) (2009) Dengue: guidelines for diagnosis, treatment, prevention and control: new edition. World Health Organization, Geneva

Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV (1992) Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30(3):545–551PubMedCentralPubMed

de Souza LJ, Nogueira RM, Soares LC, Soares CE, Ribas BF, Alves FP, Vieira FR, Pessanha FE (2007) The impact of dengue on liver function as evaluated by aminotransferase levels. Braz J Infect Dis 11:407–410CrossRefPubMed

10.

Lin YP, Luo Y, Chen Y, Lamers MM, Zhou Q, Yang XH, Sanyal S, Mok CK, Liu ZM (2016) Clinical and epidemiological features of the 2014 large-scale dengue outbreak in Guangzhou city, China. BMC Infect Dis 16(1):102CrossRefPubMedCentralPubMed

11.

Poovorawan Y, Hutagalung Y, Chongsrisawat V, Boudville I, Bock HL (2006) Dengue virus infection: a major cause of acute hepatic failure in Thai children. Ann Trop Paediatr 26:17–23CrossRefPubMed

12.

Van Gorp ECM, Suharti C, Mairuhu AT, Dolmans WM, van Der Ven J, Demacker PN, van Der Meer JW (2002) Changes in plasma lipid profile as a potential predictor of clinical outcome in dengue hemorrhagic fever. Clin Infect Dis 34(8):1150–1153CrossRefPubMed

13.

Das S, Chakraborty S, Basu A (2010) Critical role of lipid rafts in virus entry and activation of phosphoinositide 3’ kinase/Akt signaling during early stages of Japanese encephalitis virus infection in neural stem/progenitor cells. J Neurochem 115(2):537–549. https://doi.org/10.1111/j.1471-4159.2010.06951.x CrossRefPubMed

14.

Suvarna JC, Rane PP (2009) Serum lipid profile: a predictor of clinical outcome in dengue infection. Trop Med Int Health 14(5):576–585CrossRefPubMed

15.

Villar-Centeno LA, Díaz-Quijano FA, Martínez-Vega RA (2008) Biochemical alterations as markers of dengue hemorrhagic fever. Am J Trop Med Hyg 78(3):370–374CrossRefPubMed

16.

Rico-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, Boshell J, de Mesa MT, Nogueira RM, da Rosa AT (1997) Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology 230(2):244–251CrossRefPubMed

17.

Messer WB, Gubler DJ, Harris E, Sivananthan K, de Silva AM (2003) Emergence and global spread of a dengue serotype 3, subtype III virus. Emerg Infect Dis 9(7):800–809CrossRefPubMedCentralPubMed

18.

Rico-Hesse R (2003) Microevolution and virulence of dengue viruses. Adv Virus Res 59:315–341CrossRefPubMedCentralPubMed

19.

Ali A, Ali I (2015) The complete genome phylogeny of geographically distinct dengue virus serotype 2 isolates (1944–2013) supports further groupings within the cosmopolitan genotype. PLOS One 10(9):e0138900CrossRefPubMedCentralPubMed

Title: The analysis of clinical and laboratory data: a large outbreak of dengue fever in Chaozhou, Guangdong province, China
Authors: Fen Lin
Hui Yang
Lin Zhang
Sen-Hai Fang
Xiao-Fen Zhan
Li-Ye Yang
Publication date: 01-08-2019
Publisher: Springer Vienna
Keyword: Dengue Virus
Published in: Archives of Virology / Issue 8/2019
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-019-04266-1

ACC 2024 Congress Coverage

Heart Failure Video

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

The analysis of clinical and laboratory data: a large outbreak of dengue fever in Chaozhou, Guangdong province, China

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 8/2019

Full genome sequence of a new polymycovirus infecting Fusarium redolens

Genomic characterization of four novel Staphylococcus myoviruses

A novel bat-associated circovirus identified in northern Hokkaido, Japan

Epidemiology of blood-borne viral infections in Afghanistan

Complete genome characterization of three enterovirus C96 isolates in China

High-throughput sequencing of complete genomes of ipomoviruses associated with an epidemic of cassava brown streak disease in the Comoros Archipelago

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page