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01-08-2019 | Annotated Sequence Record

Complete genome characterization of three enterovirus C96 isolates in China

Authors: Qian Wang, Feng Ji, Suting Wang, Xiaojuan Lin, Zexin Tao, Aiqiang Xu

Published in: Archives of Virology | Issue 8/2019

Abstract

Enterovirus C96 (EV-C96) is a newer member of the species Enterovirus C. In this study, we determined the complete genome sequences of three EV-C96 isolates, one recovered from domestic sewage in 2013 and the other two isolated during surveillance of acute flaccid paralysis cases in 1991 and 2009, respectively. The complete genome sequences of these isolates were 75.6–84.2% identical to each other, 75.1–81.8% identical to the prototype strain, and 75.0–91.5% identical to other previously reported strains. Phylogenetic analysis of VP1 sequences revealed a high degree of genetic divergence among currently available EV-C96 sequences in the GenBank database, with an overall mean p-distance of 0.176. It is interesting to note that the 1991 strain 127/SD/CHN/1991 is the earliest EV-C96 isolate so far. Although EV-C96 is not frequently isolated during enterovirus surveillance, its great genetic diversity and the above findings suggest that this serotype has been circulating in China for many years.

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Title: Complete genome characterization of three enterovirus C96 isolates in China
Authors: Qian Wang
Feng Ji
Suting Wang
Xiaojuan Lin
Zexin Tao
Aiqiang Xu
Publication date: 01-08-2019
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 8/2019
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-019-04291-0

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