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Archives of Virology
Published in: Archives of Virology 4/2017

01-04-2017 | Brief Report

High-throughput sequencing analysis reveals the genetic diversity of different regions of the murine norovirus genome during in vitro replication

Authors: Axel Mauroy, Bernard Taminiau, Carine Nezer, Elsa Ghurburrun, Denis Baurain, Georges Daube, Etienne Thiry

Published in: Archives of Virology | Issue 4/2017

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Abstract

In this study, we report the genetic diversity and nucleotide mutation rates of five representative regions of the murine norovirus genome during in vitro passages. The mutation rates were similar in genomic regions encompassing partial coding sequences for non-structural (NS) 1-2, NS5, NS6, NS7 proteins within open reading frame (ORF) 1. In a region encoding a portion of the major capsid protein (VP1) within ORF2 (also including the ORF4 region) and a portion of the minor structural protein (VP2), the mutation rates were estimated to be at least one order of magnitude higher. The VP2 coding region was found to have the highest mutation rate.
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Metadata
Title
High-throughput sequencing analysis reveals the genetic diversity of different regions of the murine norovirus genome during in vitro replication
Authors
Axel Mauroy
Bernard Taminiau
Carine Nezer
Elsa Ghurburrun
Denis Baurain
Georges Daube
Etienne Thiry
Publication date
01-04-2017
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 4/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-016-3179-y

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Keynote webinar | Spotlight on medication adherence

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