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01-03-2017 | Original Article

Influenza virus infection induces translocation of apoptosis-inducing factor (AIF) in A549 cells: role of AIF in apoptosis and viral propagation

Authors: Xinyan Qu, Xiaoran Ding, Ming Duan, Jing Yang, Ruxian Lin, Zhe Zhou, Shengqi Wang

Published in: Archives of Virology | Issue 3/2017

Abstract

It is recognized that influenza virus induces caspase-dependent apoptosis by activating caspase-3. Apoptosis-inducing factor (AIF) is a caspase-independent cell death effector, and its mitochondrial-nuclear translocation plays an important role in apoptosis. It is demonstrated in this study how influenza virus infection can induce caspase-independent apoptosis in the human alveolar epithelial cell line A549. AIF is translocated from the mitochondria to the nucleus in a caspase-independent manner in response to infection with influenza virus. Knockdown of AIF expression by small interfering RNA (siRNA) led to a reduction in virus-infection-induced apoptosis and virus yield. These results indicate that AIF translocation has a role in influenza-virus-induced apoptosis.

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Title: Influenza virus infection induces translocation of apoptosis-inducing factor (AIF) in A549 cells: role of AIF in apoptosis and viral propagation
Authors: Xinyan Qu
Xiaoran Ding
Ming Duan
Jing Yang
Ruxian Lin
Zhe Zhou
Shengqi Wang
Publication date: 01-03-2017
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 3/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-016-3151-x

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Abstract

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