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Archives of Virology
Published in: Archives of Virology 3/2017

01-03-2017 | Review

Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections

Authors: Zhenguang Li, Xiaoqin Xu, Xue Leng, Minghui He, Jiangke Wang, Shipeng Cheng, Hua Wu

Published in: Archives of Virology | Issue 3/2017

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Abstract

Several biological processes as well as infectious agents, physiological or environmental stress, and perturbed antioxidant response can promote oxidative stress. Oxidative stress usually happens when cells are exposed to more electrically charged reactive oxygen species (ROS) such as H2O2 or O2 −. ROS are well known for being both beneficial and deleterious. Recent studies have indicated that ROS are deleterious to cells, leading to programmed cell death (PCD) at high concentrations. At low concentrations, however, ROS can act as signaling molecules in a variety of cellular processes. In this review, we present an update of our current understanding of the role and regulation of reactive oxygen species in various viral infections, cellular signaling pathways and immune responses. We then discuss how the antioxidant defense system acts as an antiviral effector to limit cell damage.
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Metadata
Title
Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections
Authors
Zhenguang Li
Xiaoqin Xu
Xue Leng
Minghui He
Jiangke Wang
Shipeng Cheng
Hua Wu
Publication date
01-03-2017
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 3/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-016-3130-2

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