Abstract
Influenza virus-infected cultured cells undergo apoptosis after an increment of Fas (APO-1/CD95) on the cell surface. By flow cytometry, cell surface Fas-ligand was detected in virus-infected cells with a time course similar to that of Fas. Moreover, Fas and Fas-ligand were co-expressed in those cells. The mode of induction, however, appeared to be distinct for the two proteins. Influenza virus infection induced the externalization of phosphatidylserine on the cell surface at the early stage of apoptosis, an event that has been observed in cells undergoing Fas-mediated apoptosis. In fact, apoptosis of the virus-infected cells was inhibited in the presence of an antagonistic anti-Fas-ligand monoclonal antibody. These results suggest that influenza virus infection causes augmented expression of both Fas and Fas-ligand and apoptosis is induced when the infected cells come into contact with each other.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Corresponding author
Additional information
Edited by M. Piacentini
Rights and permissions
About this article
Cite this article
Fujimoto, I., Takizawa, T., Ohba, Y. et al. Co-expression of Fas and Fas-ligand on the surface of influenza virus-infected cells. Cell Death Differ 5, 426–431 (1998). https://doi.org/10.1038/sj.cdd.4400362
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.cdd.4400362
Keywords
This article is cited by
-
H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses
Cell Death & Disease (2019)
-
Influenza virus infection induces translocation of apoptosis-inducing factor (AIF) in A549 cells: role of AIF in apoptosis and viral propagation
Archives of Virology (2017)
-
Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling
Apoptosis (2007)
-
Syndecan-2 expression increases serum-withdrawal-induced apoptosis, mediated by re-distribution of Fas into lipid rafts, in stably transfected Swiss 3T3 cells
Apoptosis (2006)
-
Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice
Gene Therapy (2001)