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Surgery Today
Published in: Surgery Today 7/2021

01-07-2021 | Computed Tomography | Original Article

Pathological features and prognostic implications of ground-glass opacity components on computed tomography for clinical stage I lung adenocarcinoma

Authors: Shinya Katsumata, Keiju Aokage, Genichiro Ishii, Hironobu Hoshino, Jun Suzuki, Tomohiro Miyoshi, Kenta Tane, Joji Samejima, Masahiro Tsuboi

Published in: Surgery Today | Issue 7/2021

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Abstract

Purpose

To investigate the prognostic implications and pathological features of clinical stage I lung adenocarcinoma with ground-glass opacity (GGO) on computed tomography (CT).

Methods

The subjects of this retrospective study were 1228 patients with lung adenocarcinoma classified as clinical stage I, who underwent complete resection by lobectomy. The patients were divided into four groups based on the presence and proportion of GGO according to the consolidation-to-tumor ratio (CTR); A, CTR ≤ 0.5; B, 0.5 < CTR ≤ 0.75; C, 0.75 < CTR ≤ 1.0 with GGO; D, without GGO (pure-solid). We compared overall survival, pathological findings (N/ly/v/STAS), and histological subtypes within each clinical stage among the four groups.

Results

We found no significant differences among tumors with GGO (groups A, B and C) for prognosis or pathological findings in all the clinical stages. The prognoses of groups A, B and C were significantly better than that of group D for patients with clinical stages IA2–IB disease. Tumors without GGO on CT had a significantly larger number of positive N, ly, v and STAS in almost all stages than tumors with GGO on CT. Tumors without GGO on CT had significantly more solid predominant and less lepidic predominant adenocarcinoma.

Conclusion

Not the proportion of GGO, but its presence on CT, as well as the size of the solid component, were correlated significantly with pathological characteristics and survival.
Appendix
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Metadata
Title
Pathological features and prognostic implications of ground-glass opacity components on computed tomography for clinical stage I lung adenocarcinoma
Authors
Shinya Katsumata
Keiju Aokage
Genichiro Ishii
Hironobu Hoshino
Jun Suzuki
Tomohiro Miyoshi
Kenta Tane
Joji Samejima
Masahiro Tsuboi
Publication date
01-07-2021
Publisher
Springer Singapore
Published in
Surgery Today / Issue 7/2021
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-021-02235-3

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