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01-11-2018 | Commentary

The application of neuromuscular electrical stimulation (NMES) in cancer rehabilitation: current prescription, pitfalls, and future directions

Authors: Dominic O’Connor, Brian Caulfield

Published in: Supportive Care in Cancer | Issue 11/2018

Abstract

The plethora of treatment complications associated with cancer can be offset by regular exercise participation; however, adherence to current guidelines is poor, in particular in those unable or not allowed to participate in voluntary exercise due to their underlying disease. Alternative therapies such as neuromuscular electrical stimulation (NMES) are promising although previous results in cancer survivors have been equivocal. This is likely in response to methodological issues such as inappropriate NMES prescription. Therefore, the aim of this commentary is to propose three key areas which should be addressed to increase NMES effectiveness in cancer rehabilitation; (1) NMES exercise should target both the neuromuscular and cardiovascular systems through low- and high-frequency modalities, (2) technological advancements such as mobile app-based systems should be leveraged to improve at-home monitoring of home-based NMES exercise, and (3) prescription and progression should follow the fundamental principles of exercise to overcome the heterogeneity in daily physiological, functional, and psychological factors faced by survivors. Addressing these three key areas in future studies may help improve NMES exercise effectiveness and accelerate patient rehabilitation.

Askoxylakis V, Thieke C, Pleger ST, Most P, Tanner J, Lindel K, Katus HA, Debus J, Bischof M (2010) Long-term survival of cancer patients compared to heart failure and stroke: a systematic review. BMC Cancer 10:105. https://doi.org/10.1186/1471-2407-10-105 CrossRefPubMedPubMedCentral

Malvezzi M, Carioli G, Bertuccio P, Rosso T, Boffetta P, Levi F, la Vecchia C, Negri E (2016) European cancer mortality predictions for the year 2016 with focus on leukaemias. Ann Oncol 27:725–731. https://doi.org/10.1093/annonc/mdw022 CrossRefPubMed

Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvão DA, Pinto BM, Irwin ML, Wolin KY, Segal RJ, Lucia A, Schneider CM, von Gruenigen V, Schwartz AL, American College of Sports Medicine (2010) American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42:1409–1426CrossRef

Sturgeon KM, Fisher C, McShea G, Sullivan SK, Sataloff D, Schmitz KH (2017) Patient preference and timing for exercise in breast cancer care. Support Care Cancer Off J Multinatl Assoc Support Care Cancer 26:507–514. https://doi.org/10.1007/s00520-017-3856-8 CrossRef

Maddocks M, Armstrong S, Wilcock A (2011) Exercise as a supportive therapy in incurable cancer: exploring patient preferences. Psychooncology 20:173–178. https://doi.org/10.1002/pon.1720 CrossRefPubMed

Crevenna R (2013) From neuromuscular electrical stimulation and biofeedback-assisted exercise up to triathlon competitions—regular physical activity for cancer patients in Austria. Eur Rev Aging Phys Act 10:53–55. https://doi.org/10.1007/s11556-012-0110-8 CrossRef

Maddocks M, Gao W, Higginson IJ et al (2016) Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease. Cochrane Database Syst Rev 1:CD009419. https://doi.org/10.1002/14651858.CD009419.pub3 CrossRef

Cenik F, Schoberwalter D, Keilani M, Maehr B, Wolzt M, Marhold M, Crevenna R (2016) Neuromuscular electrical stimulation of the thighs in cardiac patients with implantable cardioverter defibrillators. Wien Klin Wochenschr 128:802–808CrossRef

Crevenna R, Marosi C, Schmidinger M, Fialka-Moser V (2006) Neuromuscular electrical stimulation for a patient with metastatic lung cancer—a case report. Support Care Cancer 14:970–973. https://doi.org/10.1007/s00520-006-0033-x CrossRefPubMed

10.

Maddocks M, Lewis M, Chauhan A, Manderson C, Hocknell J, Wilcock A (2009) Randomized controlled pilot study of neuromuscular electrical stimulation of the quadriceps in patients with non-small cell lung cancer. J Pain Symptom Manag 38:950–956. https://doi.org/10.1016/j.jpainsymman.2009.05.011 CrossRef

11.

Maddocks M, Halliday V, Chauhan A, Taylor V, Nelson A, Sampson C, Byrne A, Griffiths G, Wilcock A (2013) Neuromuscular electrical stimulation of the quadriceps in patients with non-small cell lung cancer receiving palliative chemotherapy: a randomized phase II study. PLoS One 8:1–8. https://doi.org/10.1371/journal.pone.0086059 CrossRef

12.

Windholz T, Swanson T, Vanderbyl BL, Jagoe RT (2014) Correction: the feasibility and acceptability of neuromuscular electrical stimulation to improve exercise performance in patients with advanced cancer: a pilot study. BMC Palliat Care 13:33–35. https://doi.org/10.1186/1472-684X-13-33 CrossRefPubMedCentral

13.

Minogue CM, Caulfield BM, Reilly RB (2007) What are the electrical stimulation design parameters for maximum VO 2 aimed at cardio-pulmonary rehabilitation? In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. pp 2428–2431

14.

Banerjee P, Caulfield B, Crowe L, Clark AL (2009) Prolonged electrical muscle stimulation exercise improves strength, peak VO2, and exercise capacity in patients with stable chronic heart failure. J Card Fail 15:319–326. https://doi.org/10.1016/j.cardfail.2008.11.005 CrossRefPubMed

15.

Caulfield B, Prendergast A, Rainsford G, Minogue C (2013) Self directed home based electrical muscle stimulation training improves exercise tolerance and strength in healthy elderly. Conf Proc Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Conf 2013:7036–7039. https://doi.org/10.1109/EMBC.2013.6611178 CrossRef

16.

Prince S, Adamo K, Hamel M et al (2008) A comparison of direct versus self-report measures for assessing physical activity in adults: a systematic review. Int J Behav Nutr Phys Act 5:56. https://doi.org/10.1186/1479-5868-5-56 CrossRefPubMedPubMedCentral

17.

Absolom K, Holch P, Amir Z (2017) Introduction to special section on digital technology and cancer survivorship. J Cancer Surviv 11:3–5. https://doi.org/10.1007/s11764-017-0644-x CrossRef

18.

Chughtai M, Piuzzi N, Yakubek G, Khlopas A, Sodhi N, Sultan AA, Nasir S, Yates BST, Bhave A, Mont MA (2017) Use of an app-controlled neuromuscular electrical stimulation system for improved self-management of knee conditions and reduced costs. Surg Technol Int 31:221–226PubMed

19.

Sasso JP, Eves ND, Christensen JF, Koelwyn GJ, Scott J, Jones LW (2015) A framework for prescription in exercise-oncology research. J Cachexia Sarcopenia Muscle 6:115–124. https://doi.org/10.1002/jcsm.12042 CrossRefPubMedPubMedCentral

20.

Rhea MR, Alderman BL (2004) A meta-analysis of periodized versus nonperiodized strength and power training programs. Res Q Exerc Sport 75:413–422. https://doi.org/10.1080/02701367.2004.10609174 CrossRefPubMed

21.

Mann JB, Thyfault JP, Ivey PA, Sayers SP (2010) The effect of autoregulatory progressive resistance exercise vs. linear periodization on strength improvement in college athletes. J Strength Cond Res 24:1718–1723. https://doi.org/10.1519/JSC.0b013e3181def4a6 CrossRefPubMed

22.

Fairman CM, Zourdos MC, Helms ER, Focht BC (2017) A scientific rationale to improve resistance training prescription in exercise oncology. Sport Med 47:1457–1465. https://doi.org/10.1007/s40279-017-0673-7 CrossRef

Title: The application of neuromuscular electrical stimulation (NMES) in cancer rehabilitation: current prescription, pitfalls, and future directions
Authors: Dominic O’Connor
Brian Caulfield
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 11/2018
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4269-z

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