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Pediatric Nephrology
Published in: Pediatric Nephrology 4/2018

Open Access 01-04-2018 | Review

The molecular biology of pelvi-ureteric junction obstruction

Authors: Laura Jackson, Mark Woodward, Richard J. Coward

Published in: Pediatric Nephrology | Issue 4/2018

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Abstract

Over recent years routine ultrasound scanning has identified increasing numbers of neonates as having hydronephrosis and pelvi-ureteric junction obstruction (PUJO). This patient group presents a diagnostic and management challenge for paediatric nephrologists and urologists. In this review we consider the known molecular mechanisms underpinning PUJO and review the potential of utilising this information to develop novel therapeutics and diagnostic biomarkers to improve the care of children with this disorder.
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Metadata
Title
The molecular biology of pelvi-ureteric junction obstruction
Authors
Laura Jackson
Mark Woodward
Richard J. Coward
Publication date
01-04-2018
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 4/2018
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-017-3629-0

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