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Pediatric Nephrology

Published in:

01-10-2016 | Original Article

Impact of fill volume on ultrafiltration with icodextrin in children on chronic peritoneal dialysis

Authors: Sharon Rousso, Tonny M. Banh, Susan Ackerman, Elizabeth Piva, Christoph Licht, Elizabeth A. Harvey

Published in: Pediatric Nephrology | Issue 10/2016

Abstract

Background

Icodextrin is a solution of glucose polymers developed to provide sustained ultrafiltration over an extended dwell. Our aim was to determine whether or not fill volume with icodextrin contributes to the ability to achieve ultrafiltration in children.

Methods

The charts of all children on chronic peritoneal dialysis between January 2000 and July 2014 were screened for the use of an icodextrin day dwell. Data were extracted from the electronic chart and the HomeChoice™ Pro card and corrected for body surface area (BSA).

Results

Fifty children had an icodextrin day dwell. A linear correlation was found between the daytime fill volume and net ultrafiltration (p < 0.001). More ultrafiltration was achieved with a fill volume above 550 ml/m² BSA (107 ± 75 ml/m² BSA) than with smaller fill volumes (−8 ± 99 ml; p = 0.004). Ultrafiltration was achieved in 88 % of children with a fill volume above 550 ml/m² BSA versus only 44 % of patients with a smaller fill volume (p = 0.001). Icodextrin was well tolerated.

Conclusions

Our observations reveal that the larger the fill volume the higher the likelihood of achieving ultrafiltration with icodextrin and suggest that a minimum day dwell volume of 550 ml/m² BSA seems to facilitate ultrafiltration in children. To our knowledge this is the largest study addressing ultrafiltration with icodextrin in children.

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Title: Impact of fill volume on ultrafiltration with icodextrin in children on chronic peritoneal dialysis
Authors: Sharon Rousso
Tonny M. Banh
Susan Ackerman
Elizabeth Piva
Christoph Licht
Elizabeth A. Harvey
Publication date: 01-10-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 10/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-016-3398-1

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Impact of fill volume on ultrafiltration with icodextrin in children on chronic peritoneal dialysis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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