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Pediatric Nephrology
Published in: Pediatric Nephrology 10/2016

01-10-2016 | Review

Role of hypoxia during nephrogenesis

Authors: Shelby L. Hemker, Sunder Sims-Lucas, Jacqueline Ho

Published in: Pediatric Nephrology | Issue 10/2016

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Abstract

Mammals develop in a physiologically hypoxic state, and the oxygen tension of different tissues in the embryo is precisely controlled. Deviation from normal oxygenation, such as what occurs in placental insufficiency, can disrupt fetal development. Several studies demonstrate that intrauterine hypoxia has a negative effect on kidney development. As nascent nephrons are forming from nephron progenitors in the nephrogenic zone, they are exposed to varying oxygen tension by virtue of the development of the renal vasculature. Thus, nephrogenesis may be linked to oxygen tension. However, the mechanism(s) by which this occurs remains unclear. This review focuses on what is known about molecular mechanisms active in physiological and pathological hypoxia and their effects on kidney development.
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Metadata
Title
Role of hypoxia during nephrogenesis
Authors
Shelby L. Hemker
Sunder Sims-Lucas
Jacqueline Ho
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 10/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-016-3333-5

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