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Pediatric Nephrology
Published in: Pediatric Nephrology 9/2016

01-09-2016 | Educational Review

Growth hormone therapy in children with CKD after more than two decades of practice

Author: Lesley Rees

Published in: Pediatric Nephrology | Issue 9/2016

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Abstract

This review focuses on the evidence for the efficacy and safety of recombinant human growth hormone (rhGH) therapy in children with all stages of chronic kidney disease (CKD) and at all ages. It describes the improving height prognosis for our patients both with and without rhGH; explains the underlying hormonal abnormalities that provide the rationale for rhGH use in CKD and the endocrine changes that accompany treatment; and views on who warrants treatment, with what dose, and how long for.
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Literature
1.
Koch VH, Lippe BM, Nelson PA, Boechat MI, Sherman BM, Fine RN (1989) Accelerated growth after recombinant human growth hormone treatment of children with chronic renal failure. J Pediatr 115:365–371CrossRefPubMed
2.
Rees L, Rigden SP, Ward G, Preece MA (1990) Treatment of short stature in renal disease with recombinant human growth hormone. Arch Dis Child 65:856–860CrossRefPubMedPubMedCentral
3.
Tönshoff B, Mehls O, Heinrich U, Blum WF, Ranke MB, Schauer A (1990) Growth-stimulating effects of recombinant human growth hormone in children with end-stage renal disease. J Pediatr 116:561–566CrossRefPubMed
4.
Hodson EM, Willis NS, Craig JC (2012) Growth hormone for children with chronic kidney disease. Cochrane Database Syst Rev 2, CD003264PubMed
5.
6.
Mahan JD, Warady BA, Consensus Committee (2006) Assessment and treatment of short stature in pediatric patients with chronic kidney disease: a consensus statement. Pediatr Nephrol 21:917–930CrossRefPubMed
7.
8.
Kraut JA, Madias NE (2011) Consequences and therapy of the metabolic acidosis of chronic kidney disease. Pediatr Nephrol 26:19–28CrossRefPubMed
9.
Schaefer F, Hamill G, Stanhope R, Preece MA, Scharer K (1991) Pulsatile growth hormone secretion in peripubertal patients with chronic renal failure. Cooperative study group on pubertal development in chronic renal failure. J Pediatr 119:568–577CrossRefPubMed
10.
Rees L, Greene SA, Adlard P, Jones J, Haycock GB, Rigden SP, Preece M, Chantler C (1988) Growth and endocrine function in steroid sensitive nephrotic syndrome. Arch Dis Child 63:484–490CrossRefPubMedPubMedCentral
11.
Rees L, Greene SA, Adlard P, Jones J, Haycock GB, Rigden SP, Preece M, Chantler C (1988) Growth and endocrine function after renal transplantation. Arch Dis Child 63:1326–1332CrossRefPubMedPubMedCentral
12.
Tönshoff B, Cronin MJ, Reichert M, Haffner D, Wingen AM, Blum WF, Mehls O (1997) Reduced concentration of serum growth hormone (GH)-binding protein in children with chronic renal failure: correlation with GH insensitivity. The European study group for nutritional treatment of chronic renal failure in childhood. The German study group for growth hormone treatment in chronic renal failure. J Clin Endocrinol Metab 82:1007–1013CrossRefPubMed
13.
Farquharson C, Ahmed SF (2013) Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signalling. Pediatr Nephrol 28:547–556CrossRefPubMed
14.
Olney RC (2009) Mechanisms of impaired growth: effect of steroids on bone and cartilage. Horm Res 72(Suppl 1):30–35CrossRefPubMed
15.
Tönshoff B, Kiepe D, Ciarmatori S (2005) Growth hormone/insulin-like growth factor system in children with chronic renal failure. Pediatr Nephrol 20:279–289CrossRefPubMed
16.
Hokken-Koelega AC, Stijnen T, de Jong RC, Donckerwolcke RA, Groothoff JW, Wolff ED, Blum WF, de Muinck Keizer-Schrama SM, Drop SL (1996) A placebo-controlled, double-blind trial of growth hormone treatment in prepubertal children after renal transplant. Kidney Int Suppl 53:128–134
17.
Santos F, Moreno ML, Neto A, Ariceta G, Vara J, Alonso A, Bueno A, Afonso AC, Correia AJ, Muley R, Barrios V, Gómez C, Argente J (2010) Improvement in growth after 1 year of growth hormone therapy in well-nourished infants with growth retardation secondary to chronic renal failure: results of a multicenter, controlled, randomized, open clinical trial. Clin J Am Soc Nephrol 5:1190–1197CrossRefPubMedPubMedCentral
18.
Powell DR, Liu F, Baker BK, Hintz RL, Lee PD, Durham SK, Brewer ED, Frane JW, Watkins SL, Hogg RJ (1997) Modulation of growth factors by growth hormone in children with chronic renal failure. The southwest pediatric nephrology study group. Kidney Int 51:1970–1979CrossRefPubMed
19.
Hokken-Koelega AC, Stijnen T, De Jong MC, Donckerwolcke RA, De Muinck Keizer-Schrama SM, Blum WF, Drop SL (1994) Double blind trial comparing the effects of two doses of growth hormone in prepubertal patients with chronic renal insufficiency. J Clin Endocrinol Metab 79:1185–1190PubMed
20.
Hertel NT, Holmberg C, Rönnholm KA, Jacobsen BB, Olgaard K, Meeuwisse GW, Rix M, Pedersen FB (2002) Recombinant human growth hormone treatment, using two dose regimens in children with chronic renal failure—a report on linear growth and adverse effects. J Pediatr Endocrinol Metab 15:577–588CrossRefPubMed
21.
Franke D, Winkel S, Gellermann J, Querfeld U, Pape L, Ehrich JH, Haffner D, Pavičić L, Zivičnjak M (2013) Growth and maturation improvement in children on renal replacement therapy over the past 20 years. Pediatr Nephrol 28:2043–2051CrossRefPubMed
22.
Harambat J, Bonthuis M, van Stralen KJ, Ariceta G, Battelino N, Bjerre A, Jahnukainen T, Leroy V, Reusz G, Sandes AR, Sinha MD, Groothoff JW, Combe C, Jager KJ, Verrina E, Schaefer F, ESPN/ERA-EDTA Registry (2014) Adult height in patients with advanced CKD requiring renal replacement therapy during childhood. Clin J Am Soc Nephrol 9:92–99CrossRefPubMed
23.
Fine RN, Martz K, Stablein D (2010) What have 20 years of data from the North American pediatric renal transplant cooperative study taught us about growth following renal transplantation in infants, children, and adolescents with end-stage renal disease? Pediatr Nephrol 25:739–746CrossRefPubMed
24.
Klare B, Montoya CR, Fischer DC, Stangl MJ, Haffner D (2012) Normal adult height after steroid-withdrawal within 6 months of pediatric kidney transplantation: a 20 years single center experience. Transpl Int 25:276–282CrossRefPubMed
25.
Rodig NM, McDermott KC, Schneider MF, Hotchkiss HM, Yadin O, Seikaly MG, Furth SL, Warady BA (2014) Growth in children with chronic kidney disease: a report from the chronic kidney disease in children study. Pediatr Nephrol 29:1987–1995CrossRefPubMedPubMedCentral
26.
Seikaly MG, Salhab N, Gipson D, Yiu V, Stablein D (2006) Stature in children with chronic kidney disease: analysis of NAPRTCS database. Pediatr Nephrol 21:793–799CrossRefPubMed
27.
28.
Pruthi R, Maxwell H, Casula A, Braddon F, Lewis M, O’Brien C, Stojanovic J, Tse Y, Inward C, Sinha MD (2013) K Renal Registry 16th annual report: chapter 13 clinical, haematological and biochemical parameters in patients receiving renal replacement therapy in paediatric centres in the UK in 2012: national and centre-specific analyses. Nephron Clin Pract 125:259–273CrossRefPubMed
29.
30.
Rees L, Mak RH (2011) Nutrition and growth in children with chronic kidney disease. Nat Rev Nephrol 7:615–623CrossRefPubMed
31.
André JL, Bourquard R, Guillemin F, Krier MJ, Briançon S (2003) Final height in children with chronic renal failure who have not received growth hormone. Pediatr Nephrol 18:685–691PubMed
32.
Haffner D, Schaefer F, Nissel R, Wuhl E, Tönshoff B, Mehls O (2000) Effect of growth hormone treatment on the adult height of children with chronic renal failure. German study group for growth hormone treatment in chronic renal failure. N Engl J Med 343:923–930CrossRefPubMed
33.
Nissel R, Lindberg A, Mehls O, Haffner D, Pfizer International Growth Database (KIGS) International Board (2008) Factors predicting the near-final height in growth hormone-treated children and adolescents with chronic kidney disease. J Clin Endocrinol Metab 93:1359–1365CrossRefPubMed
34.
Nissel R, Latta K, Gagnadoux MF, Kelly D, Hulton S, Kemper MJ, Ruder H, Söderdahl G, Otte JB, Cochat P, Roquet O, Jamieson NV, Haffner D (2006) Body growth after combined liver-kidney transplantation in children with primary hyperoxaluria type 1. Transplantation 82:48–54CrossRefPubMed
35.
Brinkert F, Lehnhardt A, Montoya C, Helmke K, Schaefer H, Fischer L, Nashan B, Bergmann C, Ganschow R, Kemper MJ (2013) Combined liver-kidney transplantation for children with autosomal recessive polycystic kidney disease (ARPKD): indication and outcome. Transpl Int 26:640–650CrossRefPubMed
36.
37.
Schaefer F, Seidel C, Binding A, Gasser T, Largo RH, Prader A, Schärer K (1990) Pubertal growth in chronic renal failure. Pediatr Res 28:5–10CrossRefPubMed
38.
Nissel R, Brázda I, Feneberg R, Wigger M, Greiner C, Querfeld U, Haffner D (2004) Effect of renal transplantation in childhood on longitudinal growth and adult height. Kidney Int 66:792–800CrossRefPubMed
39.
Offner G, Latta K, Hoyer PF, Baum HJ, Ehrich JH, Pichlmayr R, Brodehl J (1999) Kidney transplanted children come of age. Kidney Int 55:1509–1517CrossRefPubMed
40.
Mehls O, Ritz E, Hunziker EB, Eggli P, Heinrich U, Zapf J (1988) Improvement of growth and food utilization by human recombinant growth hormone in uremia. Kidney Int 33:45–52CrossRefPubMed
41.
Powell DR, Rosenfeld RG, Hintz RL (1988) Effect of growth hormone therapy and malnutrition on the growth of rat with renal failure. Pediatr Nephrol 2:425–430CrossRefPubMed
42.
Nakano M, Kainer G, Foreman JW, Ko DJ, Chan JC (1989) The effects of exogenous rat growth hormone therapy on growth of uremic rats fed an 8% protein diet. Pediatr Res 26:204–207CrossRefPubMed
43.
Rees L, Azocar M, Borzych D, Watson AR, Büscher A, Edefonti A, Bilge I, Askenazi D, Leozappa G, Gonzales C, van Hoeck K, Secker D, Zurowska A, Rönnholm K, Bouts AH, Stewart H, Ariceta G, Ranchin B, Warady BA, Schaefer F, International Pediatric Peritoneal Dialysis Network (IPPN) registry (2011) Growth in very young children undergoing chronic peritoneal dialysis. J Am Soc Nephrol 22:2303–2312CrossRefPubMedPubMedCentral
44.
Fine RN, Attie KM, Kuntze J, Brown DF, Kohaut EC (1995) Recombinant human growth hormone in infants and young children with chronic renal insufficiency. Genentech collaborative study group. Pediatr Nephrol 9:451–457CrossRefPubMed
45.
Mencarelli F, Kiepe D, Leozappa G, Stringini G, Cappa M, Emma F (2009) Growth hormone treatment started in the first year of life in infants with chronic renal failure. Pediatr Nephrol 24:1039–1046CrossRefPubMed
46.
47.
Hokken-Koelega AC, Stijnen T, de Muinck Keizer-Schrama SM, Wit JM, Wolff ED, de Jong MC, Donckerwolcke RA, Abbad NC, Bot A, Blum WF, Drop SL (1991) Placebo-controlled, double-blind, cross-over trial of growth hormone treatment in prepubertal children with chronic renal failure. Lancet 338:585–590CrossRefPubMed
48.
Fine RN, Kohaut EC, Brown D, Perlman AJ (1994) Growth after recombinant human growth hormone treatment in children with chronic renal failure: report of a multicenter randomized double-blind placebo-controlled study. Genentech cooperative study group. J Pediatr 124:374–382CrossRefPubMed
49.
Maxwell H, Rees L (1998) Randomised controlled trial of recombinant human growth hormone in prepubertal and pubertal renal transplant recipients. British association for pediatric nephrology. Arch Dis Child 79:481–487CrossRefPubMedPubMedCentral
50.
Broyer M (1996) Results and side-effects of treating children with growth hormone after kidney transplantation - A preliminary report. Pharmacia & Upjohn study group. Acta Paediatr Suppl 417:76–79CrossRefPubMed
51.
Guest G, Bérard E, Crosnier H, Chevallier T, Rappaport R, Broyer M (1998) Effects of growth hormone in short children after renal transplantation. French society of pediatric nephrology. Pediatr Nephrol 12:437–446CrossRefPubMed
52.
Fine RN, Stablein D, Cohen AH, Tejani A, Kohaut E (2002) Recombinant human growth hormone post-renal transplantation in children: a randomized controlled study of the NAPRTCS. Kidney Int 62:688–696CrossRefPubMed
53.
Hokken-Koelega A, Mulder P, De Jong R, Lilien M, Donckerwolcke R, Groothof J (2000) Long-term effects of growth hormone treatment on growth and puberty in patients with chronic renal insufficiency. Pediatr Nephrol 14:701–706CrossRefPubMed
54.
Ito K, Kawaguchi H (1997) The use of recombinant human GH (rhGH) in growth failure in children with various renal diseases. Clin Pediatr Endocrinol 6(Suppl 9):49–53CrossRef
55.
Kitagawa T, Ito K, Ito H, Sakai T, Wada H, Kajiwara N, Multicenter Study Group of rhGH in Japan (1997) GH treatment of children with chronic renal insufficiency: a Japanese clinical trial. Clin Pediatr Endocrinol 6(Suppl 10):73–80CrossRef
56.
Hokken-Koelega AC, Stijnen T, de Ridder MA, de Muinck Keizer-Schrama SM, Wolff ED, de Jong MC, Donckerwolcke RA, Groothoff JW, Blum WF, Drop SL (1994) Growth hormone treatment in growth-retarded adolescents after renal transplant. Lancet 343(8909):1313–1317CrossRefPubMed
57.
Fine R, Kohaut E, Brown D, Kuntze J, Allie KM (1996) Long term treatment of growth retarded children with chronic renal insufficiency with recombinant growth hormone. Kidney Int 49:781–785CrossRefPubMed
58.
Bérard E, André JL, Guest G, Berthier F, Afanetti M, Cochat P, Broyer M, French Society for Pediatric Nephrology (2008) Long-term results of rhGH treatment in children with renal failure: experience of the French society of pediatric nephrology. Pediatr Nephrol 23:2031–2038CrossRefPubMed
59.
Haffner D, Wühl E, Schaefer F, Nissel R, Tönshoff B, Mehls O (1998) Factors predictive of the short- and long-term efficacy of growth hormone treatment in prepubertal children with chronic renal failure. The German study group for growth hormone treatment in chronic renal failure. J Am Soc Nephrol 9:1899–1907PubMed
60.
Kari JA, Rees L (2005) Growth hormone for children with chronic renal failure and on dialysis. Pediatr Nephrol 20:618–621CrossRefPubMed
61.
Crompton CH, Australian and New Zealand Paediatric Nephrology Association (2004) Long-term recombinant human growth hormone use in Australian children with renal disease. Nephrology 9:325–330CrossRefPubMed
62.
Janssen F, Van Damme-Lombaerts R, Van Dyck M, Hall M, Schurmans T, Herman J, Hooghe L, Van Damme B (1997) Impact of growth hormone treatment on a Belgian population of short children with renal allografts. Pediatr Transplant 1:190–196PubMed
63.
Gil S, Vaiani E, Guercio G, Ciaccio M, Turconi A, Delgado N, Rivarola MA, Belgorosky A (2012) Effectiveness of rhGH treatment on final height of renal-transplant recipients in childhood. Pediatr Nephrol 27:1005–1009CrossRefPubMed
64.
Rees L, Ward G, Rigden SPA (2000) Growth over 10 years following a 1-year trial of growth hormone therapy. Pediatr Nephrol 14:309–314CrossRefPubMed
65.
Fine RN, Sullivan EK, Tejani A (2000) The impact of recombinant human growth hormone treatment on final adult height. Pediatr Nephrol 14:679–681CrossRefPubMed
66.
Fine RN, Stablein D (2005) Long-term use of recombinant human growth hormone in pediatric allograft recipients: a report of the NAPRTCS transplant registry. Pediatr Nephrol 20:404–408CrossRefPubMed
67.
Wühl E, Haffner D, Nissel R, Schaefer F, Mehls O (1996) Short dialyzed children respond less to growth hormone than patients prior to dialysis. German study group for growth hormone treatment in chronic renal failure. Pediatr Nephrol 10:294–298CrossRefPubMed
68.
Hindmarsh PC, Brook CG (1987) Effect of growth hormone on short normal children. Br Med J 295:573–577CrossRef
69.
Deodati A, Cianfarani S (2011) Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review. BMJ 342:c7157–7165CrossRefPubMed
70.
Maxwell H, Nair DR, Dalton RN, Rigden SP, Rees L (1995) Differential effects of recombinant human growth hormone on glomerular filtration rate and renal plasma flow in chronic renal failure. Pediatr Nephrol 9:458–463CrossRefPubMed
71.
Maxwell H, Amlot P, Rees L (2000) Growth hormone and markers of immune function in children with renal transplants. Pediatr Nephrol 14:473–475CrossRefPubMed
72.
Haffner D, Nissel R, Wühl E, Schaefer F, Bettendorf M, Tönshoff B, Mehls O (1998) Metabolic effects of long-term growth hormone treatment in prepubertal children with chronic renal failure and after kidney transplantation. The German study group for growth hormone treatment in chronic renal failure. Pediatr Res 43:209–215CrossRefPubMed
73.
Ghio L, Damiani B, Garavaglia R, Oppizzi G, Taioli E, Edefonti A (2002) Lipid profile during rhGH therapy in pediatric renal transplant patients. Pediatr Transplant 6:127–131CrossRefPubMed
74.
Jedrzejowski A, Pańczyk-Tomaszewska M, Roszkowska-Blaim M, Lis D, Gałazka B, Dyras P (2002) Growth hormone therapy and lipid profile in children on chronic peritoneal dialysis. Pediatr Nephrol 17:830–836CrossRefPubMed
75.
Fischer DC, Nissel R, Puhlmann A, Mitzner A, Tiess M, Schmidt R, Haffner D (2009) Differential effects of short-term growth hormone therapy on the cardiovascular risk profile in patients with chronic kidney disease: a pilot study. Clin Nephrol 72:344–352CrossRefPubMed
76.
Nissel R, Fischer DC, Puhlmann A, Holdt-Lehmann B, Mitzner A, Petzsch M, Körber T, Tiess M, Schmidt R, Haffner D (2009) Short-term growth hormone treatment and microcirculation: effects in patients with chronic kidney disease. Microvasc Res 78:246–252CrossRefPubMed
77.
de Graaff LC, Mulder PG, Hokken-Koelega AC (2003) Body proportions before and during growth hormone therapy in children with chronic renal failure. Pediatr Nephrol 18:679–684PubMed
78.
Zivicnjak M, Franke D, Ehrich JH, Filler G (2000) Does growth hormone therapy harmonize distorted morphology and body composition in chronic renal failure? Pediatr Nephrol 15:221–228CrossRef
79.
Johnson VL, Wang J, Kaskel FJ, Pierson RN (2000) Changes in body composition of children with chronic renal failure on growth hormone. Pediatr Nephrol 14:695–700CrossRefPubMed
80.
van der Sluis IM, Boot AM, Nauta J, Hop WC, de Jong MC, Lilien MR, Groothoff JW, van Wijk AE, Pols HA, Hokken-Koelega AC, de Muinck Keizer-Schrama SM (2000) Bone density and body composition in chronic renal failure: effects of growth hormone treatment. Pediatr Nephrol 15:221–228CrossRefPubMed
81.
Doyon A, Fischer DC, Bayazit AK, Canpolat N, Duzova A, Sözeri B, Bacchetta J, Balat A, Büscher A, Candan C, Cakar N, Donmez O, Dusek J, Heckel M, Klaus G, Mir S, Özcelik G, Sever L, Shroff R, Vidal E, Wühl E, Gondan M, Melk A, Querfeld U, Haffner D, Schaefer F, 4C Study Consortium (2015) Markers of bone metabolism are affected by renal function and growth hormone therapy in children with chronic kidney disease. PLoS One 10, e0113482CrossRefPubMedPubMedCentral
82.
Nawrot-Wawrzyniak K, Misof BM, Roschger P, Pańczyk-Tomaszewska M, Ziółkowska H, Klaushofer K, Fratzl-Zelman N (2013) Changes in bone matrix mineralization after growth hormone treatment in children and adolescents with chronic kidney failure treated by dialysis: a paired biopsy study. Am J Kidney Dis 61:767–777CrossRefPubMed
83.
Bacchetta J, Wesseling-Perry K, Kuizon B, Pereira RC, Gales B, Wang HJ, Elashoff R, Salusky IB (2013) The skeletal consequences of growth hormone therapy in dialyzed children: a randomized trial. Clin J Am Soc Nephrol 8:824–832CrossRefPubMedPubMedCentral
84.
Noto R, Maneatis T, Frane J, Alexander K, Lippe B, Davis DA (2011) Intracranial hypertension in pediatric patients treated with recombinant human growth hormone: data from 25 years of the Genentech national cooperative growth study. J Pediatr Endocrinol Metab 24:627–631CrossRefPubMed
85.
Mekahli D, Ledermann S, Gullett A, Rees L (2014) Evaluation of quality of life by young adult survivors of severe chronic kidney disease in infancy. Pediatr Nephrol 29:1387–1393CrossRefPubMed
86.
Rees L (1997) Compliance with growth hormone therapy in chronic renal failure and post transplant. Pediatr Nephrol 11:752–754CrossRefPubMed
87.
Akchurin OM, Schneider MF, Mulqueen L, Brooks ER, Langman CB, Greenbaum LA, Furth SL, Moxey-Mims M, Warady BA, Kaskel FJ, Skversky AL (2014) Medication adherence and growth in children with CKD. Clin J Am Soc Nephrol 9:1519–1525CrossRefPubMedPubMedCentral
88.
Al-Uzri A, Matheson M, Gipson DS, Mendley SR, Hooper SR, Yadin O, Rozansky DJ, Moxey-Mims M, Furth SL, Warady BA, Gerson AC, Chronic Kidney Disease in Children Study Group (2013) The impact of short stature on health-related quality of life in children with chronic kidney disease. J Pediatr 163:736–741CrossRefPubMedPubMedCentral
89.
Fine RN, Brown DF, Kuntze J, Wooster P, Kohaut EE (1996) Growth after discontinuation of recombinant human growth hormone therapy in children with chronic renal insufficiency. Genentech cooperative study group. J Pediatr 129:883–889CrossRefPubMed
Metadata
Title
Growth hormone therapy in children with CKD after more than two decades of practice
Author
Lesley Rees
Publication date
01-09-2016
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 9/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-015-3179-2

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