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Pediatric Nephrology
Published in: Pediatric Nephrology 9/2016

01-09-2016 | Original Article

Desmopressin (melt) therapy in children with monosymptomatic nocturnal enuresis and nocturnal polyuria results in improved neuropsychological functioning and sleep

Authors: Charlotte Van Herzeele, Karlien Dhondt, Sanne P. Roels, Ann Raes, Piet Hoebeke, Luitzen-Albert Groen, Johan Vande Walle

Published in: Pediatric Nephrology | Issue 9/2016

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Abstract

Background

There is a high comorbidity between nocturnal enuresis, sleep disorders and psychological problems. The aim of this study was to investigate whether a decrease in nocturnal diuresis volume not only improves enuresis but also ameliorates disrupted sleep and (neuro)psychological dysfunction, the major comorbidities of this disorder.

Methods

In this open-label, prospective phase IV study, 30 children with monosymptomatic nocturnal enuresis (MNE) underwent standardized video-polysomnographic testing and multi-informant (neuro)psychological testing at baseline and 6 months after the start of desmopressin treatment in the University Hospital Ghent, Belgium. Primary endpoints were the effect on sleep and (neuro)psychological functioning. The secondary endpoint was the change in the first undisturbed sleep period or the time to the first void.

Results

Thirty children aged between 6 and 16 (mean 10.43, standard deviation 3.08) years completed the study. The results demonstrated a significant decrease in periodic limb movements during sleep (PLMS) and a prolonged first undisturbed sleep period. Additionally, (neuro)psychological functioning was improved on several domains.

Conclusions

The study demonstrates that the degree of comorbidity symptoms is at least aggravated by enuresis (and/or high nocturnal diuresis rate) since sleep and (neuro)psychological functioning were significantly ameliorated by treatment of enuresis. These results indicate that enuresis is not such a benign condition as has previously been assumed.
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Metadata
Title
Desmopressin (melt) therapy in children with monosymptomatic nocturnal enuresis and nocturnal polyuria results in improved neuropsychological functioning and sleep
Authors
Charlotte Van Herzeele
Karlien Dhondt
Sanne P. Roels
Ann Raes
Piet Hoebeke
Luitzen-Albert Groen
Johan Vande Walle
Publication date
01-09-2016
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 9/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-016-3351-3

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