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01-01-2020 | Metastasis

A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer

Authors: Ruben Ciria, Sira Ocaña, Irene Gomez-Luque, Federica Cipriani, Mark Halls, Åsmund Avdem Fretland, Yukihiro Okuda, Somaiah Aroori, Javier Briceño, Luca Aldrighetti, Bjorn Edwin, Mohammed Abu Hilal

Published in: Surgical Endoscopy | Issue 1/2020

Abstract

Background

The laparoscopic approach to liver resection has experienced exponential growth in recent years. However, evidence-based guidelines are needed for its safe future progression. The main aim of our study was to perform a systematic review and meta-analysis comparing the short- and long-term outcomes of laparoscopic and open liver resections for colorectal liver metastases (CRLM).

Methods

To identify all the comparative manuscripts between laparoscopic and open liver resections for CRLM, all published English language studies with more than ten cases were screened. In addition to the primary meta-analysis, 3 specific subgroup analyses were performed on patients undergoing minor-only, major-only and synchronous resections. The quality of the studies was assessed using the Scottish Intercollegiate Guidelines Network (SIGN) methodology and Newcastle–Ottawa Score.

Results

From the initial 194 manuscripts identified, 21 were meta-analysed, including results from the first randomized trial comparing open and laparoscopic resections of CRLM. Five of these were specific to patients undergoing a synchronous resection (399 cases), while six focused on minor (3 series including 226 cases) and major (3 series including 135 cases) resections, respectively. Thirteen manuscripts compared 2543 cases but could not be assigned to any of the above sub-analyses, so were analysed independently. The majority of short-term outcomes were favourable to the laparoscopic approach with equivalent rates of negative resection margins. No differences were observed between the approaches in overall or disease-free survival at 1, 3 or 5 years.

Conclusion

Laparoscopic liver resection for CRLM offers improved short-term outcomes with comparable long-term outcomes when compared to open approach.

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Title: A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer
Authors: Ruben Ciria
Sira Ocaña
Irene Gomez-Luque
Federica Cipriani
Mark Halls
Åsmund Avdem Fretland
Yukihiro Okuda
Somaiah Aroori
Javier Briceño
Luca Aldrighetti
Bjorn Edwin
Mohammed Abu Hilal
Publication date: 01-01-2020
Publisher: Springer US
Keywords: Metastasis
Liver Resection
Liver Resection
Colorectal Cancer
Colorectal Cancer
Published in: Surgical Endoscopy / Issue 1/2020
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-019-06774-2

Keynote webinar | Spotlight on sleep in brain health

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A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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