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Published in: Surgical Endoscopy 1/2020

01-01-2020 | Rectal Cancer | Dynamic Manuscript

Feasibility of transanal total mesorectal excision (taTME) using the Medrobotics Flex® System

Authors: Heather Carmichael, Anthony P. D’Andrea, Matthew Skancke, Vincent Obias, Patricia Sylla

Published in: Surgical Endoscopy | Issue 1/2020

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Abstract

Background

The use of transanal total mesorectal excision (taTME) for treatment of rectal cancer is growing, but anatomic constraints prevent access to the proximal rectum with rigid instruments. The articulated instrumentation of current surgical robots is promising in overcoming these limitations, but the bulky size of current platforms inhibits the proximal reach of dissection. Flexible robotic systems could overcome these constraints while maintaining a stable platform for dissection. The goal of this study was to evaluate feasibility of performing taTME using the semi-robotic Flex® System (Medrobotics Corp., Raynham, MA) in human cadavers.

Methods

taTME was performed by two surgeons in six fresh human cadaveric specimens using the Flex® System, with or without transabdominal laparoscopic assistance. Both mid- and low-rectal lesions were simulated. Metrics including quality of visualization, maintenance of pneumorectum, maneuverability of instruments, effectiveness of pursestring suture placement, and dissection in an anatomically correct plane were evaluated.

Results

The semi-robotic endoluminal platform allowed for excellent visualization, insufflation, and dissection during taTME. Adequate pursestring occlusion of the rectum was achieved in all six cases. In cadavers with simulated mid-rectal lesions (N = 4), dissection and anterior peritoneal entry was achieved in all cases, with abdominal assistance utilized in two of four cases. In cadavers with simulated low-rectal lesions (N = 2), dissection was incomplete and aborted due to difficulty maneuvering instruments in close proximity to the rigid transanal port.

Conclusions

Use of the Flex® system for taTME is feasible for mid-rectal dissection. Advantages over the traditional multi-armed robot include longer reach of instruments with the ability to dissect up to 17 cm from the anal verge, as well as tactile feedback. The current design of the flexible platform does not permit safe dissection in the distal rectum, although this constraint may be resolved with future adjustments to the equipment.
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Literature
1.
go back to reference MacFarlane JK, Ryall RD, Heald RJ (1993) Mesorectal excision for rectal cancer. Lancet 341:457–460CrossRef MacFarlane JK, Ryall RD, Heald RJ (1993) Mesorectal excision for rectal cancer. Lancet 341:457–460CrossRef
2.
go back to reference Marijnen CA, Kapiteijn E, van de Velde CJ, Martijn H, Steup WH, Wiggers T, Kranenbarg EK, Leer JW, Cooperative Investigators of the Dutch Colorectal Cancer Group (2002) Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol 20:817–825CrossRef Marijnen CA, Kapiteijn E, van de Velde CJ, Martijn H, Steup WH, Wiggers T, Kranenbarg EK, Leer JW, Cooperative Investigators of the Dutch Colorectal Cancer Group (2002) Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol 20:817–825CrossRef
3.
go back to reference Snijders H, Wouters M, van Leersum N, Kolfschoten N, Henneman D, de Vries A, Tollenaar R, Bonsing B (2012) Meta-analysis of the risk for anastomotic leakage, the postoperative mortality caused by leakage in relation to the overall postoperative mortality. Eur J Surg Oncol 38:1013–1019CrossRef Snijders H, Wouters M, van Leersum N, Kolfschoten N, Henneman D, de Vries A, Tollenaar R, Bonsing B (2012) Meta-analysis of the risk for anastomotic leakage, the postoperative mortality caused by leakage in relation to the overall postoperative mortality. Eur J Surg Oncol 38:1013–1019CrossRef
4.
go back to reference Jeong S, Park J, Nam B, Kim S, Kang S, Lim S, Choi H, Kim D, Chang H, Kim D, Jung K, Kim T, Kang G, Chie E, Kim S, Sohn D, Kim D, Kim J, Lee H, Kim J, Oh J (2014) Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial. Lancet Oncol 15:767–774CrossRef Jeong S, Park J, Nam B, Kim S, Kang S, Lim S, Choi H, Kim D, Chang H, Kim D, Jung K, Kim T, Kang G, Chie E, Kim S, Sohn D, Kim D, Kim J, Lee H, Kim J, Oh J (2014) Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial. Lancet Oncol 15:767–774CrossRef
5.
go back to reference Ohtani H, Tamamori Y, Azuma T, Mori Y, Nishiguchi Y, Maeda K, Hirakawa K (2011) A meta-analysis of the short- and long-term results of randomized controlled trials that compared laparoscopy-assisted and conventional open surgery for rectal cancer. J Gastrointest Surg 15:1375–1385CrossRef Ohtani H, Tamamori Y, Azuma T, Mori Y, Nishiguchi Y, Maeda K, Hirakawa K (2011) A meta-analysis of the short- and long-term results of randomized controlled trials that compared laparoscopy-assisted and conventional open surgery for rectal cancer. J Gastrointest Surg 15:1375–1385CrossRef
6.
go back to reference Kang S, Park J, Jeong S, Nam B, Choi H, Kim D, Lim S, Lee T, Kim D, Kim J, Chang H, Lee H, Kim S, Jung K, Hong Y, Kim J, Sohn D, Kim D, Oh J (2010) Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial. Lancet Oncol 11:637–645CrossRef Kang S, Park J, Jeong S, Nam B, Choi H, Kim D, Lim S, Lee T, Kim D, Kim J, Chang H, Lee H, Kim S, Jung K, Hong Y, Kim J, Sohn D, Kim D, Oh J (2010) Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial. Lancet Oncol 11:637–645CrossRef
7.
go back to reference Kang C, Halabi W, Luo R, Pigazzi A, Nguyen N, Stamos M (2012) Laparoscopic colorectal surgery: a better look into the latest trends. Arch Surg 147:724–731CrossRef Kang C, Halabi W, Luo R, Pigazzi A, Nguyen N, Stamos M (2012) Laparoscopic colorectal surgery: a better look into the latest trends. Arch Surg 147:724–731CrossRef
8.
go back to reference Guillou P, Quirke P, Thorpe H, Walker J, Jayne D, Smith A, Heath R, Brown J, MRC CLASICC trial group (2005) Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 365:1718–1726CrossRef Guillou P, Quirke P, Thorpe H, Walker J, Jayne D, Smith A, Heath R, Brown J, MRC CLASICC trial group (2005) Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 365:1718–1726CrossRef
9.
go back to reference van der Pas M, Haglind E, Cuesta M, Fürst A, Lacy A, Hop W, Bonjer H, COlorectal cancer Laparoscopic or Open Resection II (COLOR II) Study Group (2013) Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol 14:210–218CrossRef van der Pas M, Haglind E, Cuesta M, Fürst A, Lacy A, Hop W, Bonjer H, COlorectal cancer Laparoscopic or Open Resection II (COLOR II) Study Group (2013) Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol 14:210–218CrossRef
10.
go back to reference Green B, Marshall H, Collinson F, Quirke P, Guillou P, Jayne D, Brown J (2013) Long-term follow-up of the Medical Research Council CLASICC trial of conventional versus laparoscopically assisted resection in colorectal cancer. Br J Surg 100:75–82CrossRef Green B, Marshall H, Collinson F, Quirke P, Guillou P, Jayne D, Brown J (2013) Long-term follow-up of the Medical Research Council CLASICC trial of conventional versus laparoscopically assisted resection in colorectal cancer. Br J Surg 100:75–82CrossRef
11.
go back to reference Fleshman J, Branda M, Sargent D, Boller A, George V, Abbas M, Peters W, Maun D, Chang G, Herline A, Fichera A, Mutch M, Wexner S, Whiteford M, Marks J, Birnbaum E, Margolin D, Larson D, Marcello P, Posner M, Read T, Monson J, Wren S, Pisters P, Nelson H (2015) Effect of laparoscopic-assisted resection vs open resection of stage II or III rectal cancer on pathologic outcomes: the ACOSOG Z6051 randomized clinical trial. JAMA 314:1356–1364CrossRef Fleshman J, Branda M, Sargent D, Boller A, George V, Abbas M, Peters W, Maun D, Chang G, Herline A, Fichera A, Mutch M, Wexner S, Whiteford M, Marks J, Birnbaum E, Margolin D, Larson D, Marcello P, Posner M, Read T, Monson J, Wren S, Pisters P, Nelson H (2015) Effect of laparoscopic-assisted resection vs open resection of stage II or III rectal cancer on pathologic outcomes: the ACOSOG Z6051 randomized clinical trial. JAMA 314:1356–1364CrossRef
12.
go back to reference Stevenson A, Solomon M, Lumley J, Hewett P, Clouston A, Gebski V, Davies L, Wilson K, Hague W, Simes J (2015) Effect of laparoscopic-assisted resection vs open resection on pathological outcomes in rectal cancer: the ALaCaRT randomized clinical trial. JAMA 314:1356–1363CrossRef Stevenson A, Solomon M, Lumley J, Hewett P, Clouston A, Gebski V, Davies L, Wilson K, Hague W, Simes J (2015) Effect of laparoscopic-assisted resection vs open resection on pathological outcomes in rectal cancer: the ALaCaRT randomized clinical trial. JAMA 314:1356–1363CrossRef
13.
go back to reference Collinson F, Jayne D, Pigazzi A, Tsang C, Barrie J, Edlin R, Garbett C, Guillou P, Holloway I, Howard H, Marshall H, McCabe C, Pavitt S, Quirke P, Rivers C, Brown J (2012) An international, multicentre, prospective, randomised, controlled, unblinded, parallel-group trial of robotic-assisted versus standard laparoscopic surgery for the curative treatment of rectal cancer. Int J Colorectal Dis 27:233–241CrossRef Collinson F, Jayne D, Pigazzi A, Tsang C, Barrie J, Edlin R, Garbett C, Guillou P, Holloway I, Howard H, Marshall H, McCabe C, Pavitt S, Quirke P, Rivers C, Brown J (2012) An international, multicentre, prospective, randomised, controlled, unblinded, parallel-group trial of robotic-assisted versus standard laparoscopic surgery for the curative treatment of rectal cancer. Int J Colorectal Dis 27:233–241CrossRef
14.
go back to reference Tyler J, Fox J, Desai M, Perry W, Glasgow S (2013) Outcomes and costs associated with robotic colectomy in the minimally invasive era. Dis Colon Rectum 56:458–466CrossRef Tyler J, Fox J, Desai M, Perry W, Glasgow S (2013) Outcomes and costs associated with robotic colectomy in the minimally invasive era. Dis Colon Rectum 56:458–466CrossRef
15.
go back to reference Jayne D, Pigazzi A, Marshall H, Croft J, Corrigan N, Copeland J, Quirke P, West N, Rautio T, Thomassen N, Tilney H, Gudgeon M, Bianchi P, Edlin R, Hulme C, Brown J (2017) Effect of robotic-assisted vs conventional laparoscopic surgery on risk of conversion to open laparotomy among patients undergoing resection for rectal cancer: the ROLARR Randomized Clinical Trial. JAMA 318:1569–1580CrossRef Jayne D, Pigazzi A, Marshall H, Croft J, Corrigan N, Copeland J, Quirke P, West N, Rautio T, Thomassen N, Tilney H, Gudgeon M, Bianchi P, Edlin R, Hulme C, Brown J (2017) Effect of robotic-assisted vs conventional laparoscopic surgery on risk of conversion to open laparotomy among patients undergoing resection for rectal cancer: the ROLARR Randomized Clinical Trial. JAMA 318:1569–1580CrossRef
16.
go back to reference Sylla P, Sohn D, Cizginer S, Konuk Y, Turner B, Gee D, Willingham F, Hsu M, Mino-Kenudson M, Brugge W, Rattner D (2010) Survival study of natural orifice translumenal endoscopic surgery for rectosigmoid resection using transanal endoscopic microsurgery with or without transgastric endoscopic assistance in a swine model. Surg Endosc 24:2022–2030CrossRef Sylla P, Sohn D, Cizginer S, Konuk Y, Turner B, Gee D, Willingham F, Hsu M, Mino-Kenudson M, Brugge W, Rattner D (2010) Survival study of natural orifice translumenal endoscopic surgery for rectosigmoid resection using transanal endoscopic microsurgery with or without transgastric endoscopic assistance in a swine model. Surg Endosc 24:2022–2030CrossRef
17.
go back to reference Sylla P, Rattner D, Delgado S, Lacy A (2010) NOTES transanal rectal cancer resection using transanal endoscopic microsurgery and laparoscopic assistance. Surg Endosc 24:1205–1210CrossRef Sylla P, Rattner D, Delgado S, Lacy A (2010) NOTES transanal rectal cancer resection using transanal endoscopic microsurgery and laparoscopic assistance. Surg Endosc 24:1205–1210CrossRef
18.
go back to reference Telem D, Han K, Kim M, Ajari I, Sohn D, Woods K, Kapur V, Sbeih M, Perretta S, Rattner D, Sylla P (2013) Transanal rectosigmoid resection via natural orifice translumenal endoscopic surgery (NOTES) with total mesorectal excision in a large human cadaver series. Surg Endosc 27:74–80CrossRef Telem D, Han K, Kim M, Ajari I, Sohn D, Woods K, Kapur V, Sbeih M, Perretta S, Rattner D, Sylla P (2013) Transanal rectosigmoid resection via natural orifice translumenal endoscopic surgery (NOTES) with total mesorectal excision in a large human cadaver series. Surg Endosc 27:74–80CrossRef
19.
go back to reference Penna M, Hompes R, Arnold S, Wynn G, Austin R, Warusavitarne J, Moran B, Hanna G, Mortensen N, Tekkis P, Collaborative TR (2016) Transanal total mesorectal excision: international registry results of the first 720 cases. Ann Surg 266:111CrossRef Penna M, Hompes R, Arnold S, Wynn G, Austin R, Warusavitarne J, Moran B, Hanna G, Mortensen N, Tekkis P, Collaborative TR (2016) Transanal total mesorectal excision: international registry results of the first 720 cases. Ann Surg 266:111CrossRef
20.
21.
go back to reference Maykel J (2015) Laparoscopic transanal total mesorectal excision (taTME) for rectal cancer. J Gastrointest Surg 19:1880–1888CrossRef Maykel J (2015) Laparoscopic transanal total mesorectal excision (taTME) for rectal cancer. J Gastrointest Surg 19:1880–1888CrossRef
22.
go back to reference Koedam T, Veltcamp Helbach M, Van de Ven P, Kryut P, van Heek N, Bonjer H, Tuynman J, Sietses C (2018) Transanal total mesorectal excision for rectal cancer: evaluation of the learning curve. Tech Coloproctol 22:279–287CrossRef Koedam T, Veltcamp Helbach M, Van de Ven P, Kryut P, van Heek N, Bonjer H, Tuynman J, Sietses C (2018) Transanal total mesorectal excision for rectal cancer: evaluation of the learning curve. Tech Coloproctol 22:279–287CrossRef
24.
go back to reference Atallah S, Parra-Davila E, DeBeche-Adams T, Albert M, Larach S (2012) Excision of a rectal neoplasm using robotic transanal surgery (RTS): a description of the technique. Tech Coloproctol 16:389–392CrossRef Atallah S, Parra-Davila E, DeBeche-Adams T, Albert M, Larach S (2012) Excision of a rectal neoplasm using robotic transanal surgery (RTS): a description of the technique. Tech Coloproctol 16:389–392CrossRef
25.
go back to reference Verheijen P, Consten E, Broeders I (2014) Robotic transanal total mesorectal excision for rectal cancer: experience with a first case. Int J Med Robot 10:423–426CrossRef Verheijen P, Consten E, Broeders I (2014) Robotic transanal total mesorectal excision for rectal cancer: experience with a first case. Int J Med Robot 10:423–426CrossRef
26.
go back to reference Gómez Ruiz M, Parra I, Palazuelos C, Martín J, Fernández C, Diego J, Fleitas M (2015) Robotic-assisted laparoscopic transanal total mesorectal excision for rectal cancer: a prospective pilot study. Dis Colon Rectum 58:145–153CrossRef Gómez Ruiz M, Parra I, Palazuelos C, Martín J, Fernández C, Diego J, Fleitas M (2015) Robotic-assisted laparoscopic transanal total mesorectal excision for rectal cancer: a prospective pilot study. Dis Colon Rectum 58:145–153CrossRef
27.
go back to reference Atallah S, Martin-Perez B, Pinan J, Quinteros F, Schoonyoung H, Albert M, Larach S (2014) Robotic transanal total mesorectal excision: a pilot study. Tech Coloproctol 18:1047–1053CrossRef Atallah S, Martin-Perez B, Pinan J, Quinteros F, Schoonyoung H, Albert M, Larach S (2014) Robotic transanal total mesorectal excision: a pilot study. Tech Coloproctol 18:1047–1053CrossRef
28.
go back to reference Huscher C, Bretagnol F, Ponzano C (2015) Robotic-assisted transanal total mesorectal excision: the key against the Achilles’ heel of rectal cancer? Ann Surg 261:e120–121CrossRef Huscher C, Bretagnol F, Ponzano C (2015) Robotic-assisted transanal total mesorectal excision: the key against the Achilles’ heel of rectal cancer? Ann Surg 261:e120–121CrossRef
29.
go back to reference Kuo L, Ngu J, Tong Y, Chen C (2017) Combined robotic transanal total mesorectal excision (R-taTME) and single-site plus one-port (R-SSPO) technique for ultra-low rectal surgery-initial experience with a new operation approach. Int J Colorectal Dis 32:249–254CrossRef Kuo L, Ngu J, Tong Y, Chen C (2017) Combined robotic transanal total mesorectal excision (R-taTME) and single-site plus one-port (R-SSPO) technique for ultra-low rectal surgery-initial experience with a new operation approach. Int J Colorectal Dis 32:249–254CrossRef
30.
go back to reference Atallah S (2017) Assessment of a flexible robotic system for endoluminal applications and transanal total mesorectal excision (taTME): could this be the solution we have been searching for? Tech Coloproctol 21:809–814CrossRef Atallah S (2017) Assessment of a flexible robotic system for endoluminal applications and transanal total mesorectal excision (taTME): could this be the solution we have been searching for? Tech Coloproctol 21:809–814CrossRef
31.
go back to reference Johnson P, Rivera Serrano C, Castro M, Kuenzler R, Choset H, Tully S, Duvvuri U (2013) Demonstration of transoral surgery in cadaveric specimens with the medrobotics flex system. Laryngoscope 123:1168–1172CrossRef Johnson P, Rivera Serrano C, Castro M, Kuenzler R, Choset H, Tully S, Duvvuri U (2013) Demonstration of transoral surgery in cadaveric specimens with the medrobotics flex system. Laryngoscope 123:1168–1172CrossRef
32.
go back to reference Remacle M, Prasad MN, Lawson G, Plisson L, Bachy V, Van der Vorst S (2015) Transoral robotic surgery (TORS) with the Medrobotics Flex™ System: first surgical application on humans. Eur Arch Otorhinolaryngol 272:1451–1455CrossRef Remacle M, Prasad MN, Lawson G, Plisson L, Bachy V, Van der Vorst S (2015) Transoral robotic surgery (TORS) with the Medrobotics Flex™ System: first surgical application on humans. Eur Arch Otorhinolaryngol 272:1451–1455CrossRef
33.
go back to reference Mandapathil M, Duvvuri U, Güldner C, Teymoortash A, Lawson G, Werner J (2015) Transoral surgery for oropharyngeal tumors using the Medrobotics(®) Flex(®) System—a case report. Int J Surg Case Rep 10:173–175CrossRef Mandapathil M, Duvvuri U, Güldner C, Teymoortash A, Lawson G, Werner J (2015) Transoral surgery for oropharyngeal tumors using the Medrobotics(®) Flex(®) System—a case report. Int J Surg Case Rep 10:173–175CrossRef
34.
go back to reference Lang S, Mattheis S, Hasskamp P, Lawson G, Güldner C, Mandapathil M, Schuler P, Hoffmann T, Scheithauer M, Remacle M (2017) A european multicenter study evaluating the flex robotic system in transoral robotic surgery. Laryngoscope 127:391–395CrossRef Lang S, Mattheis S, Hasskamp P, Lawson G, Güldner C, Mandapathil M, Schuler P, Hoffmann T, Scheithauer M, Remacle M (2017) A european multicenter study evaluating the flex robotic system in transoral robotic surgery. Laryngoscope 127:391–395CrossRef
35.
go back to reference Jafari M, Carmichael J, Kopchok G, Pigazzi A (2017) A pilot study to evaluate a flexible robot for transanal surgery Jafari M, Carmichael J, Kopchok G, Pigazzi A (2017) A pilot study to evaluate a flexible robot for transanal surgery
36.
go back to reference Friedrich D, Dürselen L, Mayer B, Hacker S, Schall F, Hahn J, Hoffmann T, Schuler P, Greve J (2018) Features of haptic and tactile feedback in TORS—a comparison of available surgical systems. J Robot Surg 12:103–108CrossRef Friedrich D, Dürselen L, Mayer B, Hacker S, Schall F, Hahn J, Hoffmann T, Schuler P, Greve J (2018) Features of haptic and tactile feedback in TORS—a comparison of available surgical systems. J Robot Surg 12:103–108CrossRef
Metadata
Title
Feasibility of transanal total mesorectal excision (taTME) using the Medrobotics Flex® System
Authors
Heather Carmichael
Anthony P. D’Andrea
Matthew Skancke
Vincent Obias
Patricia Sylla
Publication date
01-01-2020
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 1/2020
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-019-07019-y

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