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International Archives of Occupational and Environmental Health

Published in:

01-07-2019 | Original Article

Blue–yellow dyschromatopsia in toluene-exposed workers

Authors: Axel Muttray, Volkmar Wolters, Dirk-Matthias Rose

Published in: International Archives of Occupational and Environmental Health | Issue 5/2019

Abstract

Purpose

To evaluate the effects of a chronic occupational exposure to toluene on color vision.

Methods

Color vision was tested in 51 workers exposed to pure toluene and in 51 matched control subjects. Current exposure was determined by biological monitoring. Blood samples were taken at the end of a Friday shift. Color vision ability was assessed using the Ishihara plates (to screen for congenital dyschromatopsia), the Farnsworth panel D-15 test, the Lanthony panel D-15 desaturated test, the Velhagen plates, and the Standard Pseudoisochromatic Plates Part 2.

Results

Median toluene concentration was 1.59 mg/l (quartiles 0.78 and 2.65). The whole group of workers did not perform worse than the controls. The same applies to 20 printers, who regularly assessed hues. Assessed with the most sensitive Lanthony panel D-15 desaturated test, color vision of 24 permanently exposed assistants was impaired (median color confusion index of the 1st eyes 1.08 vs. 1.02, p < 0.02; 2nd eyes 1.08 vs. 1.0, p < 0.05; sign test). The assistants made almost exclusively blue–yellow errors. The other color vision tests did not reveal any differences between the groups.

Conclusion

Changes in the retina are a possible explanation for the observed blue–yellow dyschromatopsia.

Agency for Toxic Substances Disease Registry (2017) Toxicological profile for toluene. https://www.atsdr.cdc.gov/toxprofiles/tp56.pdf. Accessed 25 Jan 2019

Angerer J (1985) Occupational chronic exposure to organic solvents. XII. O-cresol excretion after toluene exposure. Int Arch Occup Environ Health 56:323–328CrossRef

Angerer J et al (1998) Lösemittelgemische. In: Greim H (ed) Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Band 1: Luftanalysen. Wiley, Hoboken, pp 1–12

Arden GB, Wolf JE (2004) Colour vision testing as an aid to diagnosis and management of age related maculopathy. Br J Ophthalmol 88:1180–1185. https://doi.org/10.1136/bjo.2003.033480 CrossRef

Arrighi HM, Hertz-Picciotto I (1994) The evolving concept of the healthy worker survivor effect. Epidemiology 5:189–196CrossRef

Baelum J, Andersen IB, Lundqvist GR, Molhave L, Pedersen OF, Vaeth M, Wyon DP (1985) Response of solvent-exposed printers and unexposed controls to six-hour toluene exposure. Scand J Work Environ Health 11:271–280CrossRef

Berry KP, Nedivi E (2016) Experience-dependent structural plasticity in the visual system. Annu Rev Vis Sci 2:17–35. https://doi.org/10.1146/annurev-vision-111815-114638 CrossRef

Birch J, Chisholm IA, Kinnear P, Pinckers AJLG, Pokorny J, Smith VC, Verriest G (1979) Clinical testing methods. In: Pokorny J, Smith VC, Verriest G, Pinckers AJLG (eds) Congenital and acquired color vision defects. Grune & Stratton, New York, pp 83–135

Böckelmann I, Lindner H, Peters B, Pfister EA (2003) Einfluss langjähriger beruflicher Lösungsmittelexposition auf das Farbensehen. Ophthalmologe 100:133–141CrossRef

Bowman KJ (1982) A method for quantitative scoring of the Farnsworth Panel D-15. Acta Ophthalmol Copenh 60:907–916CrossRef

Bowman KJ, Cameron KD (1984) A quantitative assessment of colour discrimination in normal vision and senile macular degeneration using some colour confusion tests. In: Verriest G (ed) Colour vision deficiencies VII. Dr W. Junk, The Hague Boston Lancaster, pp 363–370

Boyes WK et al (2007) Acute toluene exposure and rat visual function in proportion to momentary brain concentration. Toxicol Sci 99:572–581. https://doi.org/10.1093/toxsci/kfm172 CrossRef

Boyes WK et al (2016) Toluene inhalation exposure for 13 weeks causes persistent changes in electroretinograms of Long-Evans rats. Neurotoxicology 53:257–270. https://doi.org/10.1016/j.neuro.2016.02.008 CrossRef

Campagna D, Stengel B, Mergler D, Limasset JC, Diebold F, Michard D, Huel G (2001) Color vision and occupational toluene exposure. Neurotoxicol Teratol 23:473–480CrossRef

Cavalleri A, Gobba F, Nicali E, Fiocchi V (2000) Dose-related color vision impairment in toluene-exposed workers. Arch Environ Health 55:399–404CrossRef

Cole BL (2004) The handicap of abnormal colour vision. Clin Exp Optom 87:258–275CrossRef

Costa TL, Barboni MT, Moura AL, Bonci DM, Gualtieri M, de Lima Silveira LC, Ventura DF (2012) Long-term occupational exposure to organic solvents affects color vision, contrast sensitivity and visual fields. PLoS One 7:e42961. https://doi.org/10.1371/journal.pone.0042961 CrossRef

Cruz SL, Rivera-Garcia MT, Woodward JJ (2014) Review of toluene action: clinical evidence, animal studies and molecular targets. J Drug Alcohol Res. https://doi.org/10.4303/jdar/235840 CrossRef

Deleu D, Hanssens Y (2000) Cerebellar dysfunction in chronic toluene abuse: beneficial response to amantadine hydrochloride. J Toxicol Clin Toxicol 38:37–41CrossRef

Deutsche Forschungsgemeinschaft Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe (1998) Toluol (Nachtrag). Gesundheitsschädliche Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten. Wiley, Weinheim. https://onlinelibrary.wiley.com/doi/pdf/10.1002/3527600418.mb10888d0027. Accessed 25 Jan 2019

Deutsche Forschungsgemeinschaft Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe (2016) MAK- und BAT-Werte-Liste 2016. Wiley, Weinheim. http://onlinelibrary.wiley.com/book/10.1002/9783527805976. Accessed 25 Jan 2019

Farnsworth D (1943) The Farnsworth-Munsell 100-Hue and dichotomous tests for color vision. J Opt Soc Am 33:568–578CrossRef

Feitosa-Santana C et al (2008) Irreversible color vision losses in patients with chronic mercury vapor intoxication. Vis Neurosci 25:487–491. https://doi.org/10.1017/s0952523808080590 CrossRef

Fox DA (2015) Retinal and visual system: occupational and environmental toxicology. In: Lotti M, Bleecker ML (eds) Handbook of Clinical Neurology, vol 131. 2015/11/14 edn. Elsevier, Amsterdam, pp 325–340. https://doi.org/10.1016/b978-0-444-62627-1.00017-2

Geller AM, Hudnell HK (1997) Critical issues in the use and analysis of the Lanthony Desaturate Color Vision test. Neurotoxicol Teratol 19:455–465CrossRef

Gobba F, Cavalleri A (2003) Color vision impairment in workers exposed to neurotoxic chemicals. Neurotoxicology 24:693–702CrossRef

Grant MW, Schuman JS (eds) (1993) Toxicology of the eye. Charles C. Thomas. Springfield

Gupta SR, Palmer CA, Cure JK, Balos LL, Lincoff NS, Kline LB (2011) Toluene optic neurotoxicity: magnetic resonance imaging and pathologic features. Hum Pathol 42:295–298. https://doi.org/10.1016/j.humpath.2010.08.005 CrossRef

Hart WM (1987) Acquired dyschromatopsias. Surv Ophthalmol 32:10–31CrossRef

Holló G, Varga M (1992) Toluene and visual loss. Neurology 42:266CrossRef

Huchzermeyer C, Kremers J, Barbur J (2016) Color vision in clinical practice. In: Kremers J, Baraas RC, Marshall NJ (eds) Human color vision. Springer, Cham, pp 269–315. https://doi.org/10.1007/978-3-319-44978-4_10 CrossRef

Ichikawa K, Hukami K, Tanabe S (1983) Standard Pseudoisochromatic Plates Part II for acquired color vision defects. Igaku-Shoin, Tokyo New York

Iregren A, Andersson M, Nylen P (2002) Color vision and occupational chemical exposures: I. An overview of tests and effects. Neurotoxicology 23:719–733CrossRef

Ishihara S (1990) The series of plates designed as a test for colour blindness, 24. plates edn. Kanehara, Tokyo

Kiyokawa M, Mizota A, Takasoh M, Adachi-Usami E (1999) Pattern visual evoked cortical potentials in patients with toxic optic neuropathy caused by toluene abuse. Jpn J Ophthalmol 43:438–442CrossRef

Köllner H (1912) Die Störungen des Farbensinnes und ihre klinische Bedeutung und ihre Diagnose. S. Karger, BerlinCrossRef

Krastel H, Gehrung H, Dax K, Rohrschneider K (1991) Clinical application of the Heidelberg anomaloscope. In: Drum B, Moreland JD, Serra A (eds) Colour vision deficiencies X. Kluwer, Dordrecht, pp 135–149CrossRef

Krastel H, Kolling G, Schiefer U, Bach M (2009) Qualitätsanforderungen an die Untersuchung des Farbsinns. Ophthalmologe 106:1083–1102CrossRef

Kurtenbach A, Kernstock C, Zrenner E, Langrova H (2015) Electrophysiology and colour: a comparison of methods to evaluate inner retinal function. Doc Ophthalmol 131:159–167. https://doi.org/10.1007/s10633-015-9512-z CrossRef

Lacerda EM, Lima MG, Rodrigues AR, Teixeira CE, de Lima LJ, Ventura DF, Silveira LC (2012) Psychophysical evaluation of achromatic and chromatic vision of workers chronically exposed to organic solvents. J Environ Public Health 2012:784390. https://doi.org/10.1155/2012/784390 CrossRef

Lanthony P (1978) The desaturated panel D-15. Doc Ophthalmol 46:185–189

Lomax RB, Ridgway P, Meldrum M (2004) Does occupational exposure to organic solvents affect colour discrimination? Toxicol Rev 23:91–121CrossRef

Lyle WM (1974) Drugs and conditions which may affect color vision. Part II. Diseases and conditions. J Am Optom Assoc 45:173–182

Malm G, Lying Tunell U (1980) Cerebellar dysfunction related to toluene sniffing. Acta Neurol Scand 62:188–190CrossRef

Marjot R, McLeod AA (1989) Chronic non-neurological toxicity from volatile substance abuse. Hum Toxicol 8:301–306CrossRef

Marré M, Marré E (eds) (1986) Erworbene Störungen des Farbensehens—Diagnostik. VEB Georg Thieme, Leipzig

Marré M, Marré E, Eckardt T (1991) Der SPP-II-Test (Standard Pseudoisochromatic Plates Part II)—eine Untersuchungsmethode für erworbene Farbensehstörungen. Spektrum Augenheilk 5:51–58CrossRef

Mergler D (1994) Neurotoxicology of the visual system. Part 1: Early indications of visual dysfunction. In: Bleecker ML (ed) Occupational neurology and clinical neurotoxicology. Williams and Wilkins, Baltimore, pp 161–172

Muttray A, Wolters V, Mayer-Popken O, Schicketanz KH, Konietzko J (1995) Effect of subacute occupational exposure to toluene on color vision. Int J Occup Med Environ Health 8:339–345

Muttray A, Wolff U, Jung D, Konietzko J (1997) Blue-yellow deficiency in workers exposed to low concentrations of organic solvents. Int Arch Occup Environ Health 70:407–412CrossRef

Muttray A, Unger C, Jung D, Konietzko J (1998a) Erworbene Farbensehstörungen in der Arbeitswelt. Teil 1: Diagnostik und Referenzwerte. Arbeitsmed Sozialmed Umweltmed 33:144–152

Muttray A, Wolters V, Wolff U, Konietzko J (1998b) Erworbene Farbensehstörungen in der Arbeitswelt. Teil 2: Untersuchungen zur Eignung bei erworbenen und angeborenen Farbensehstörungen. Arbeitsmed Sozialmed Umweltmed 33:183–189

Muttray A, Wolters V, Jung D, Konietzko J (1999) Effects of high doses of toluene on color vision. Neurotoxicol Teratol 21:41–45CrossRef

Muttray A, Loos AH, Jung D, Rose D-M (2002) Muß der MAK-Wert für CS2 wegen erworbener Farbsinnesstörungen gesenkt werden? (letter). Arbeitsmed Sozialmed Umweltmed 37:47

Neubert D, Bochert G, Gericke C, Hanke B, Beckmann G (2001) Multicenter field trial on possible health effects of toluene. I. Toluene body burdens in workers of the rotogravure industry. Toxicology 168:139–157CrossRef

Özgen E, Davies IR (2002) Acquisition of categorical color perception: a perceptual learning approach to the linguistic relativity hypothesis. J Exp Psychol Gen 131:477–493CrossRef

Paramei GV (2012) Color discrimination across four life decades assessed by the Cambridge Colour Test. J Opt Soc Am A Opt Image Sci Vis 29:A290–A297. https://doi.org/10.1364/josaa.29.00a290 CrossRef

Paramei GV, Meyer-Baron M, Seeber A (2004) Impairments of colour vision induced by organic solvents: a meta-analysis study. Neurotoxicology 25:803–816CrossRef

Pinckers A, Marre M (1992) An analysis of colour vision in 10,000 patients. Doc Ophthalmol 82:25–28CrossRef

Pinckers A, Nabbe B, van den Boyaard P (1976) Le test 15 Hue désaturé de Lanthony. Ann Ocul 209:731–738

Pinckers A, Nabbe B, Vossen H (1985) Standard Pseudoisochromatic Plates part 2. Ophthalmologica 190:118–124CrossRef

Pokorny J, Collins B, Howett G, Lakowski R, Lewis M (1981) Procedures for testing color vision. Committee on Vision, National Research Council, Washington

Raitta C, Seppalainen AN, Huuskonen MS (1978) N-hexane maculopathy in industrial workers. Albrecht von Graefes Arch Klin Exp Ophthalmol 209:99–110CrossRef

Ristic I, Stankovic S, Paravina RD (2016) Influence of color education and training on shade matching skills. J Esthet Restor Dent 28:287–294. https://doi.org/10.1111/jerd.12209 CrossRef

Roy MS, Podgor MJ, Collier B, Gunkel RD (1991) Color vision and age in a normal North American population. Graefes Arch Clin Exp Ophthalmol 229:139–144CrossRef

Russell RM, Carney EA, Feiock K, Garrett M, Karwoski P (1980) Acute ethanol administration causes transient impairment of blue-yellow color vision. Alcohol Clin Exp Res 4:396–399CrossRef

Santaella RM, Fraunfelder FW (2007) Ocular adverse effects associated with systemic medications: recognition and management. Drugs 67:75–93CrossRef

Schäper M, Demes P, Kiesswetter E, Zupanic M, Seeber A (2004) Colour vision and occupational toluene exposure: results of repeated examinations. Toxicol Lett 151:193–202CrossRef

Taubert M, Villringer A, Ragert P (2012) Learning-related gray and white matter changes in humans: an update. Neuroscientist 18:320–325. https://doi.org/10.1177/1073858411419048 CrossRef

Toyonaga N, Adachi-Usami E, Yamazaki H (1989) Clinical and electrophysiological findings in three patients with toluene dependency. Doc Ophthalmol 73:201–207CrossRef

Urban P, Lukas E (1990) Visual evoked potentials in rotogravure printers exposed to toluene. Br J Ind Med 47:819–823

Velhagen K, Broschmann D (1989) Tafeln zur Prüfung des Farbensinnes. Thieme, Stuttgart New York

Verriest G (1963) Further studies on acquired deficiency of color discrimination. J Opt Soc Am 53:185–195CrossRef

Vrca A, Bozicevic D, Bozikov V, Fuchs R, Malinar M (1997) Brain stem evoked potentials and visual evoked potentials in relation to the length of occupational exposure to low levels of toluene. Acta Med Croatica 51:215–219

World Health Organization (ed) (1985) Toluene (Environmental Health Criteria 52). Geneva

Yücel M, Takagi M, Walterfang M, Lubman DI (2008) Toluene misuse and long-term harms: a systematic review of the neuropsychological and neuroimaging literature. Neurosci Biobehav Rev 32:910–926. https://doi.org/10.1016/j.neubiorev.2008.01.006 CrossRef

Zavalic M, Mandic Z, Turk R, Bogadi Sare A, Plavec D (1998) Quantitative assessment of color vision impairment in workers exposed to toluene. Am J Ind Med 33:297–304CrossRef

Zrenner E, Riedel KG, Adamczyk R, Gilg T, Liebhardt E (1986) Effects of ethyl alcohol on the electrooculogram and color vision. Doc Ophthalmol 63:305–312CrossRef

Title: Blue–yellow dyschromatopsia in toluene-exposed workers
Authors: Axel Muttray
Volkmar Wolters
Dirk-Matthias Rose
Publication date: 01-07-2019
Publisher: Springer Berlin Heidelberg
Published in: International Archives of Occupational and Environmental Health / Issue 5/2019
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-019-01405-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Blue–yellow dyschromatopsia in toluene-exposed workers

Abstract

Purpose

Methods

Results

Conclusion

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Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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