Abstract
We recorded the electrophysiological findings of three patients with toluene dependency who developed visual disturbance. In five of six eyes the peak latency of the pattern visual evoked cortical potential was prolonged as compared with that of normal subjects. The amplitude and the latency of the a-wave of the electroretinogram were decreased in five of the six eyes and prolonged in four. Those of the b-wave in patients were less affected than the a-wave: in one of six eyes the amplitude of the b-wave was decreased and in two the b-wave latency was prolonged. The amplitudes of the oscillatory potentials were decreased in three of six eyes. The electroretinogram was investigated in one patient and showed little increase in amplitude during light stimulation, so that a lowered light peak to dark trough ratio was obtained.
Our findings suggest that any part of the visual pathway, including the distal part of the retina and retinal pigment epithelium, might be impaired by the chronic inhalation of toluene vapors.
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Abbreviations
- EOG:
-
Electrooculogram
- ERG:
-
Electroretinogram
- L/D:
-
light peak to dark trough ratio
- OP:
-
Oscillatory potential
- VECP:
-
Visual evoked cortical potential
References
Grabski DA. Toluene sniffing producing cerebellar degeneration. Am J Psychiatr 1961; 8: 461–2.
Streicher HZ, Gabow PA, Moss AH, Kono D, Kaehny WD. Syndromes of toluene sniffing in adults. Ann Intern Med 1981; 94: 758–62.
Lazar RB, Ho SU, Melen O, Daghestani AN. Multifocal central nervous system damage caused by toluene abuse. Neurology 1983; 33: 1337–40.
Grant WM. Toxicology of the eye, 3rd ed. Illinois: Charles C Thomas Publisher, 1986; 927.
Kimura T, Fujiwara N, Miyata M, Ishikawa S. Optico-encephalo-neuropathy in glue sniffer. In Salim I, ed. Transactions of the Sixth Congress of the Asia-Pacific Academy of Ophthalmology. Indonesia: Airlangga University Press; 1976: 176–81.
Keane JR. Toluene optic neuropathy. Ann Neurol 1978; 4: 390.
Malm G, Lying-Tunell U. Cerebellar dysfunction related to toluene sniffing. Acta Neurol Scand 1980; 62: 188–90.
Metrick SA, Brenner RP. Abnormal brainstem auditory evoked potentials in chronic paint sniffers. Ann Neurol 1982; 12: 553–6.
Ehyai A, Freemon FR. Progressive optic neuropathy and sensorineural hearing loss due to chronic glue sniffing. J Neurol Neurosurg Psychiatry 1983; 46: 349–51.
Martin DA, Heckenlively JR. The normal electroretinogram. Doc Ophthalmol Proc Series 1982; 31: 135–44.
Adachi-Usami E. Studies on the method of measurement of oscillatory potential on ERG. Acta Soc Ophthalmol Jpn 1966; 70: 84–7.
Jones RM, Stevens TS, Gould S. Normal EOG values of young subjects. Doc Ophthalmol Proc Series 1977; 13; 88–92.
Escobar A, Aruffo V. Chronic thinner intoxication: clinicopathologic report of a human case. J Neurol Neurosurg Psychiatry 1980; 43: 986–994.
Wachtmeister L, Dowling JE. Laminar profile study of the oscillatory potentials of the vertebrate electroretinogram. In Tazawa Y, ed. Proceedings of the 16th ISCEV Symposium, Morioka, 1978. Jpn J Ophthalmol 1979; 355–60.
Skoog K-O, Nilsson SEG. Changes in the c-wave of the electroretinogram and in the standing potential of the eye after small doses of toluene and styrene. Acta Ophthalmol 1981; 59: 71–9.
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Toyonaga, N., Adachi-Usami, E. & Yamazaki, H. Clinical and electrophysiological findings in three patients with toluene dependency. Doc Ophthalmol 73, 201–207 (1989). https://doi.org/10.1007/BF00155038
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DOI: https://doi.org/10.1007/BF00155038