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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-03-2020 | Strabismus | Pediatrics

Multifocal electroretinography in amblyopia

Authors: Christiane Al-Haddad, Alaa Bou Ghannam, Zeinab El Moussawi, Elza Rachid, Karine Ismail, Marwan Atallah, Larissa Smeets, Hasan Chahine

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 3/2020

Abstract

Purpose

To identify whether there are functional abnormalities in the retina of amblyopic eyes using multifocal electroretinography (mfERG).

Methods

This is a prospective study of patients ≥ 7 years of age identified with unilateral amblyopia (strabismic or anisometropic). Multifocal ERG and flash ERG were performed to compare parameters between the amblyopic and non-amblyopic fellow eyes. A complete analysis of the five ring averages was done including the central ring.

Results

Thirty-eight patients were included: mean age was 14.3 ± 7.3 years; 18 patients were strabismic and 20 were anisometropic. Amblyopic eye responses across the rings in multifocal ERG were diminished compared with fellow non-amblyopic eyes with significant differences detected in the central rings (p = 0.001). On the other hand, flash ERG did not show any consistently significant differences. When divided by severity, amplitudes of central rings were significantly lower in severely amblyopic eyes compared with non-amblyopic eyes (p = 0.001), while in mild amblyopia, no significant differences were observed. No significant difference was observed between anisometropic and strabismic amblyopic eyes.

Conclusions

Using multifocal ERG, significantly decreased amplitudes were observed in amblyopic eyes compared with normal fellow eyes in the central ring. This correlated with the severity of amblyopia. No difference was observed when comparing the two groups of amblyopia (strabismic and anisometropic). Those findings may help clarify the pathophysiology of amblyopia better and open the door for new objective ways to monitor the response to amblyopia treatment but this needs to be further studied.

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Title: Multifocal electroretinography in amblyopia
Authors: Christiane Al-Haddad
Alaa Bou Ghannam
Zeinab El Moussawi
Elza Rachid
Karine Ismail
Marwan Atallah
Larissa Smeets
Hasan Chahine
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Keywords: Strabismus
Strabismus
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 3/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04558-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Multifocal electroretinography in amblyopia

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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